Skip to Main content Skip to Navigation
Journal articles

DNA repair and mutations during quiescence in yeast

Abstract : Life is maintained through alternating phases of cell division and quiescence. The causes and consequences of spontaneous mutations have been extensively explored in proliferating cells, and the major sources include errors of DNA replication and DNA repair. The foremost consequences are genetic variations within a cell population that can lead to heritable diseases and drive evolution. While most of our knowledge on DNA damage response and repair has been gained through cells actively dividing, it remains essential to also understand how DNA damage is metabolized in cells which are not dividing. In this review, we summarize the current knowledge concerning the type of lesions that arise in non-dividing budding and fission yeast cells, as well as the pathways used to repair them. We discuss the contribution of these models to our current understanding of age-related pathologies.
Document type :
Journal articles
Complete list of metadatas

Cited literature [183 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-01868274
Contributor : Benoit Arcangioli <>
Submitted on : Wednesday, February 13, 2019 - 11:22:07 AM
Last modification on : Monday, January 13, 2020 - 5:08:18 PM
Long-term archiving on: : Tuesday, May 14, 2019 - 4:54:49 PM

File

Gangloff&Arcangioli_revised.pd...
Files produced by the author(s)

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Serge Gangloff, Benoît Arcangioli. DNA repair and mutations during quiescence in yeast. FEMS Yeast Research, Oxford University Press (OUP), 2017, 17 (1), ⟨10.1093/femsyr/fox002⟩. ⟨pasteur-01868274⟩

Share

Metrics

Record views

180

Files downloads

398