M. Beurg, R. Fettiplace, J. Nam, and A. Ricci, Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging, Nature Neuroscience, vol.18, issue.5, pp.553-558, 2009.
DOI : 10.1016/S0006-3495(96)79429-8

J. Pickles, S. Comis, and M. Osborne, Cross-links between stereocilia in the guinea pig organ of Corti, and their possible relation to sensory transduction, Hearing Research, vol.15, issue.2, pp.103-112, 1984.
DOI : 10.1016/0378-5955(84)90041-8

C. Petit and G. Richardson, Linking genes underlying deafness to hair-bundle development and function, Nature Neuroscience, vol.249, issue.6, pp.703-710, 2009.
DOI : 10.1016/S1388-1981(01)00165-2

P. Kazmierczak, H. Sakaguchi, J. Tokita, E. Wilson-kubalek, R. Milligan et al., Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells, Nature, vol.15, issue.7158, pp.87-91, 2007.
DOI : 10.1038/nature06091

E. Pepermans, V. Michel, R. Goodyear, C. Bonnet, S. Abdi et al., The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells, EMBO Molecular Medicine, vol.6, issue.7, pp.984-992, 2014.
DOI : 10.15252/emmm.201403976

URL : https://hal.archives-ouvertes.fr/pasteur-01237053

G. Lefevre, V. Michel, D. Weil, L. Lepelletier, E. Bizard et al., A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth, Development, vol.135, issue.8, pp.1427-1437, 2008.
DOI : 10.1242/dev.012922

N. Michalski, V. Michel, E. Caberlotto, G. Lefevre, A. Van-aken et al., Harmonin-b, an actin-binding scaffold protein, is involved in the adaptation of mechanoelectrical transduction by sensory hair cells, Pfl??gers Archiv - European Journal of Physiology, vol.82, issue.1, pp.115-130, 2009.
DOI : 10.1113/jphysiol.1991.sp018475

N. Grillet, W. Xiong, A. Reynolds, P. Kazmierczak, T. Sato et al., Harmonin Mutations Cause Mechanotransduction Defects in Cochlear Hair Cells, Neuron, vol.62, issue.3, pp.375-387, 2009.
DOI : 10.1016/j.neuron.2009.04.006

A. Bahloul, V. Michel, J. Hardelin, S. Nouaille, S. Hoos et al., Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids, Human Molecular Genetics, vol.5, issue.18, pp.3557-3565, 2010.
DOI : 10.1093/hmg/5.8.1171

E. Caberlotto, V. Michel, I. Foucher, A. Bahloul, R. Goodyear et al., Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia, Proceedings of the National Academy of Sciences, vol.456, issue.7219, pp.5825-5830, 2011.
DOI : 10.1038/nature07380

URL : https://hal.archives-ouvertes.fr/pasteur-01472844

M. Grati and B. Kachar, Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction, Proceedings of the National Academy of Sciences, vol.135, issue.8, pp.11476-11481, 2011.
DOI : 10.1242/dev.012922

J. Yan, L. Pan, X. Chen, L. Wu, and M. Zhang, The structure of the harmonin/sans complex reveals an unexpected interaction mode of the two Usher syndrome proteins, Proceedings of the National Academy of Sciences, vol.60, issue.Pt 3, pp.4040-4045, 2010.
DOI : 10.1107/S0907444903028956

M. Bitner-glindzicz, K. Lindley, P. Rutland, D. Blaydon, V. Smith et al., A recessive contiguous gene deletion causing infantile hyperinsulinism, enteropathy and deafness identifies the Usher type 1C gene, Nature Genetics, vol.26, issue.1, pp.56-60, 2000.
DOI : 10.1038/79171

E. Verpy, M. Leibovici, I. Zwaenepoel, X. Liu, A. Gal et al., A defect in harmonin, a PDZ domain-containing protein expressed in the inner ear sensory hair cells, underlies Usher syndrome type 1C, Nature Genetics, vol.26, issue.1, pp.51-55, 2000.
DOI : 10.1038/79178

B. Boeda, A. El-amraoui, A. Bahloul, R. Goodyear, L. Daviet et al., Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle, The EMBO Journal, vol.21, issue.24, pp.6689-6699, 2002.
DOI : 10.1093/emboj/cdf689

J. Siemens, P. Kazmierczak, A. Reynolds, M. Sticker, A. Littlewood-evans et al., The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions, Proceedings of the National Academy of Sciences, vol.269, issue.5231, pp.14946-14951, 2002.
DOI : 10.1126/science.7569905

A. Adato, V. Michel, Y. Kikkawa, J. Reiners, K. Alagramam et al., Interactions in the network of Usher syndrome type 1 proteins, Human Molecular Genetics, vol.14, issue.3, pp.347-356, 2005.
DOI : 10.1007/s004290050088

L. Wu, L. Pan, C. Zhang, and M. Zhang, Large Protein Assemblies Formed by Multivalent Interactions between Cadherin23 and Harmonin Suggest a Stable Anchorage Structure at the Tip Link of Stereocilia, Journal of Biological Chemistry, vol.78, issue.40, pp.33460-33471, 2012.
DOI : 10.1038/nature10879

J. Reiners, B. Reidel, A. El-amraoui, B. Boeda, I. Huber et al., Differential Distribution of Harmonin Isoforms and Their Possible Role in Usher-1 Protein Complexes in Mammalian Photoreceptor Cells, Investigative Opthalmology & Visual Science, vol.44, issue.11, pp.5006-5015, 2003.
DOI : 10.1167/iovs.03-0483

K. Luck, S. Charbonnier, and G. Trave, The emerging contribution of sequence context to the specificity of protein interactions mediated by PDZ domains, FEBS Letters, vol.25, issue.17, pp.2648-2661, 2012.
DOI : 10.1093/bioinformatics/btp033

F. Ye and M. Zhang, Structures and target recognition modes of PDZ domains: recurring themes and emerging pictures, Biochemical Journal, vol.22, issue.1, pp.1-14, 2013.
DOI : 10.1038/sj.emboj.7601651

L. Pan, Y. J. Wu, L. Zhang, and M. , Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23, Proceedings of the National Academy of Sciences, vol.14, issue.1, pp.5575-5580, 2009.
DOI : 10.1016/0263-7855(96)00009-4

G. David and J. Perez, Combined sampler robot and high-performance liquid chromatography: a fully automated system for biological small-angle X-ray scattering experiments at the Synchrotron SOLEIL SWING beamline, Journal of Applied Crystallography, vol.42, issue.5, pp.892-900, 2009.
DOI : 10.1107/S0021889809029288

P. Konarev, V. Volkov, A. Sokolova, M. Koch, and D. Svergun, : a Windows PC-based system for small-angle scattering data analysis, Journal of Applied Crystallography, vol.36, issue.5, pp.1277-1282, 2003.
DOI : 10.1107/S0021889803012779

A. Guinier, La diffraction des rayons X aux tr es petits angles: application a l' etude de ph enom enes ultramicroscopiques 26 Svergun DI (1992) Determination of the regularization parameter in indirect-transform methods using perceptual criteria, J Appl Crystallogr, vol.25, pp.495-503, 1939.

H. Fischer, M. Neto, H. Napolitano, I. Polikarpov, and A. Craievich, Determination of the molecular weight of proteins in solution from a single small-angle X-ray scattering measurement on a relative scale, Journal of Applied Crystallography, vol.313, issue.1, pp.101-109, 2010.
DOI : 10.1107/S0021889809043076/ce5058sup1.pdf

R. Rambo and J. Tainer, Accurate assessment of mass, models and resolution by small-angle scattering, Nature, vol.94, issue.7446, pp.477-481, 2013.
DOI : 10.1529/biophysj.107.113415

M. Petoukhov and D. Svergun, Global Rigid Body Modeling of Macromolecular Complexes against Small-Angle Scattering Data, Biophysical Journal, vol.89, issue.2, pp.1237-1250, 2005.
DOI : 10.1529/biophysj.105.064154

D. Svergun, C. Barberato, and M. Koch, ??? a Program to Evaluate X-ray Solution Scattering of Biological Macromolecules from Atomic Coordinates, Journal of Applied Crystallography, vol.28, issue.6, pp.768-773, 1995.
DOI : 10.1107/S0021889895007047

P. Bernado, E. Mylonas, M. Petoukhov, M. Blackledge, and D. Svergun, Structural Characterization of Flexible Proteins Using Small-Angle X-ray Scattering, Journal of the American Chemical Society, vol.129, issue.17, pp.5656-5664, 2007.
DOI : 10.1021/ja069124n

G. Tria, H. Mertens, M. Kachala, and D. Svergun, Advanced ensemble modelling of flexible macromolecules using X-ray solution scattering, IUCrJ, vol.107, issue.2, pp.207-217, 2015.
DOI : 10.1107/S205225251500202X/fc5007sup1.pdf

B. Moore, L. Kelley, J. Barber, J. Murray, and J. Macdonald, High-quality protein backbone reconstruction from alpha carbons using Gaussian mixture models, Journal of Computational Chemistry, vol.67, issue.22, pp.1881-1889, 2013.
DOI : 10.1107/S0108767311096711

, 2299?2310 ª 2017 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies 34 Krivov GG Improved prediction of protein side-chain conformations with SCWRL4, Letters Shapovalov MV and Dunbrack RL Proteins, vol.591, issue.77, pp.778-795, 2009.

B. Berger, D. Wilson, E. Wolf, T. Tonchev, M. Milla et al., Predicting coiled coils by use of pairwise residue correlations., Proceedings of the National Academy of Sciences, vol.92, issue.18, pp.8259-8263, 1995.
DOI : 10.1073/pnas.92.18.8259

A. Lupas, M. Van-dyke, and J. Stock, Predicting coiled coils from protein sequences, Science, vol.252, issue.5009, pp.1162-1164, 1991.
DOI : 10.1126/science.252.5009.1162

E. Wolf, P. Kim, and B. Berger, MultiCoil: A program for predicting two-and three-stranded coiled coils, Protein Science, vol.4, issue.6, pp.1179-1189, 1997.
DOI : 10.1002/pro.5560040818

L. Kelley, S. Mezulis, C. Yates, M. Wass, and M. Sternberg, The Phyre2 web portal for protein modeling, prediction and analysis, Nature Protocols, vol.1, issue.6, pp.845-858, 2015.
DOI : 10.1093/bioinformatics/btl677

F. Morales, Y. Takahashi, S. Momin, H. Adams, X. Chen et al., NHERF1/EBP50 Head-to-Tail Intramolecular Interaction Masks Association with PDZ Domain Ligands, Molecular and Cellular Biology, vol.27, issue.7, pp.2527-2537, 2007.
DOI : 10.1128/MCB.01372-06

H. Lee, J. Zheng, L. Cladiere, F. Lecointe, D. Durand et al., PDZ domains and their binding partners: structure, specificity, and modification The family X DNA polymerase from Deinococcus radiodurans adopts a non-standard extended conformation, Cell Commun Signal J Biol Chem, vol.8, issue.284, pp.11992-11999, 2009.

H. Boze, T. Marlin, D. Durand, J. Perez, A. Vernhet et al., Proline-Rich Salivary Proteins Have Extended Conformations, Biophysical Journal, vol.99, issue.2, pp.656-665, 2010.
DOI : 10.1016/j.bpj.2010.04.050