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Infection Reveals a Modification of SIRT2 Critical for Chromatin Association

Abstract : Graphical Abstract Highlights d Infection induces modification of the host deacetylase SIRT2 to target it to chromatin d Dephosphorylation of serine 25 on SIRT2 controls its subcellular localization d PPM1A and PPM1B form a nuclear complex to dephosphorylate serine 25 d The phosphorylation state of serine 25 is crucial for Listeria infection (P.C.), (M.A.H.) In Brief Sirtuins are enzymes critical for various processes, including genomic stability, metabolism, and aging. Through study of Listeria monocytogenes, a bacterial pathogen that exploits SIRT2 for productive infection, Pereira et al. uncover a SIRT2 modification necessary for chromatin association and function.
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Submitted on : Tuesday, August 14, 2018 - 3:26:59 PM
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Jorge Vitório Pereira, Christine Chevalier, Thibault Chaze, Quentin Giai Gianetto, Francis Impens, et al.. Infection Reveals a Modification of SIRT2 Critical for Chromatin Association. Cell Reports, 2018, 23 (4), pp.1124 - 1137. ⟨10.1016/j.celrep.2018.03.116⟩. ⟨pasteur-01857244⟩



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