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Journal Articles Cell Reports Year : 2018

Infection Reveals a Modification of SIRT2 Critical for Chromatin Association

Abstract

Graphical Abstract Highlights d Infection induces modification of the host deacetylase SIRT2 to target it to chromatin d Dephosphorylation of serine 25 on SIRT2 controls its subcellular localization d PPM1A and PPM1B form a nuclear complex to dephosphorylate serine 25 d The phosphorylation state of serine 25 is crucial for Listeria infection (P.C.), melanie.hamon@pasteur.fr (M.A.H.) In Brief Sirtuins are enzymes critical for various processes, including genomic stability, metabolism, and aging. Through study of Listeria monocytogenes, a bacterial pathogen that exploits SIRT2 for productive infection, Pereira et al. uncover a SIRT2 modification necessary for chromatin association and function.
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Dates and versions

pasteur-01857244 , version 1 (14-08-2018)

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Attribution - NonCommercial - NoDerivatives - CC BY 4.0

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Jorge Vitório Pereira, Christine Chevalier, Thibault Chaze, Quentin Giai Gianetto, Francis Impens, et al.. Infection Reveals a Modification of SIRT2 Critical for Chromatin Association. Cell Reports, 2018, 23 (4), pp.1124 - 1137. ⟨10.1016/j.celrep.2018.03.116⟩. ⟨pasteur-01857244⟩
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