Skip to Main content Skip to Navigation
Journal articles

Infection Reveals a Modification of SIRT2 Critical for Chromatin Association

Abstract : Graphical Abstract Highlights d Infection induces modification of the host deacetylase SIRT2 to target it to chromatin d Dephosphorylation of serine 25 on SIRT2 controls its subcellular localization d PPM1A and PPM1B form a nuclear complex to dephosphorylate serine 25 d The phosphorylation state of serine 25 is crucial for Listeria infection (P.C.), melanie.hamon@pasteur.fr (M.A.H.) In Brief Sirtuins are enzymes critical for various processes, including genomic stability, metabolism, and aging. Through study of Listeria monocytogenes, a bacterial pathogen that exploits SIRT2 for productive infection, Pereira et al. uncover a SIRT2 modification necessary for chromatin association and function.
Document type :
Journal articles
Complete list of metadatas

Cited literature [48 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-01857244
Contributor : Marie-Therese Vicente <>
Submitted on : Tuesday, August 14, 2018 - 3:26:59 PM
Last modification on : Tuesday, May 26, 2020 - 10:31:30 PM
Long-term archiving on: : Thursday, November 15, 2018 - 3:30:07 PM

File

Cell Reports_Pereira.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License

Identifiers

Collections

Citation

Jorge Pereira, Christine Chevalier, Thibault Chaze, Quentin Gianetto, Francis Impens, et al.. Infection Reveals a Modification of SIRT2 Critical for Chromatin Association. Cell Reports, Elsevier Inc, 2018, 23 (4), pp.1124 - 1137. ⟨10.1016/j.celrep.2018.03.116⟩. ⟨pasteur-01857244⟩

Share

Metrics

Record views

525

Files downloads

491