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Journal articles
Infection Reveals a Modification of SIRT2 Critical for Chromatin Association
Abstract : Graphical Abstract Highlights d Infection induces modification of the host deacetylase SIRT2 to target it to chromatin d Dephosphorylation of serine 25 on SIRT2 controls its subcellular localization d PPM1A and PPM1B form a nuclear complex to dephosphorylate serine 25 d The phosphorylation state of serine 25 is crucial for Listeria infection (P.C.), melanie.hamon@pasteur.fr (M.A.H.) In Brief Sirtuins are enzymes critical for various processes, including genomic stability, metabolism, and aging. Through study of Listeria monocytogenes, a bacterial pathogen that exploits SIRT2 for productive infection, Pereira et al. uncover a SIRT2 modification necessary for chromatin association and function.
Cited literature [48 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-01857244
Contributor : Marie-Therese Vicente Connect in order to contact the contributor
Submitted on : Tuesday, August 14, 2018 - 3:26:59 PM
Last modification on : Wednesday, December 1, 2021 - 4:48:02 PM
Long-term archiving on: : Thursday, November 15, 2018 - 3:30:07 PM
Contributor : Marie-Therese Vicente Connect in order to contact the contributor
Submitted on : Tuesday, August 14, 2018 - 3:26:59 PM
Last modification on : Wednesday, December 1, 2021 - 4:48:02 PM
Long-term archiving on: : Thursday, November 15, 2018 - 3:30:07 PM
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Cell Reports_Pereira.pdf
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