E. R. Moxon and J. S. Kroll, Curr Top Microbiol, vol.150, pp.65-85, 1990.

I. Lerouge and J. Vanderleyden, O-antigen structural variation: mechanisms and possible roles in animal/plant???microbe interactions, FEMS Microbiology Reviews, vol.26, issue.1, pp.17-47, 2002.
DOI : 10.1016/S0008-6215(00)82139-4

L. E. Comstock and D. L. Kasper, Bacterial Glycans: Key Mediators of Diverse Host Immune Responses, Cell, vol.126, issue.5, pp.847-850, 2006.
DOI : 10.1016/j.cell.2006.08.021

S. K. Mazmanian and D. L. Kasper, The love???hate relationship between bacterial polysaccharides and the host immune system, Nature Reviews Immunology, vol.61, issue.Suppl. 49, pp.849-858, 2006.
DOI : 10.1097/01.qco.0000224821.27482.bd

M. Caroff and D. Karibian, Structure of bacterial lipopolysaccharides, Carbohydrate Research, vol.338, issue.23, pp.2431-2447, 2003.
DOI : 10.1016/j.carres.2003.07.010

Y. A. , Bacterial Lipopolysaccharides, pp.41-115, 2011.

L. M. Willis and C. Whitfield, Structure, biosynthesis, and function of bacterial capsular polysaccharides synthesized by ABC transporter-dependent pathways, Carbohydrate Research, vol.378, pp.35-44, 2013.
DOI : 10.1016/j.carres.2013.05.007

S. N. Chatterjee and K. Chaudhuri, Lipopolysaccharides of Vibrio cholerae, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1639, issue.2, pp.65-79, 2003.
DOI : 10.1016/j.bbadis.2003.08.004

F. Orskov, I. Orskov, A. Sutton, R. Schneerson, W. Lin et al., Form variation in Escherichia coli K1: determined by O-acetylation of the capsular polysaccharide, Journal of Experimental Medicine, vol.149, issue.3, pp.669-685, 1979.
DOI : 10.1084/jem.149.3.669

S. Herget, P. V. Toukach, R. Ranzinger, W. E. Hull, Y. A. Knirel et al., BMC Struct Biol, vol.8, p.20, 2008.

A. Adibekian, P. Stallforth, M. L. Hecht, D. B. Werz, P. Gagneux et al., Chem Sci, issue.2, pp.337-344, 2011.

R. Stenutz, A. Weintraub, and G. Widmalm, O-polysaccharide antigens, FEMS Microbiology Reviews, vol.10, issue.3, pp.382-403, 2006.
DOI : 10.1016/S0008-6215(01)00123-9

H. Yu and X. Chen, Carbohydrate post-glycosylational modifications, Organic & Biomolecular Chemistry, vol.83, issue.Pt 2, pp.865-872, 2007.
DOI : 10.1042/bj3130589

S. M. Muthana, C. T. Campbell, and J. C. Gildersleeve, Modifications of Glycans: Biological Significance and Therapeutic Opportunities, ACS Chemical Biology, vol.7, issue.1, pp.31-43, 2012.
DOI : 10.1021/cb2004466

X. Lemercinier and C. Jones, Full 1H NMR assignment and detailed O-acetylation patterns of capsular polysaccharides from Neisseria meningitidis used in vaccine production, Carbohydrate Research, vol.296, issue.1-4, pp.83-96, 1996.
DOI : 10.1016/S0008-6215(96)00253-4

E. L. Nazarenko, R. J. Crawford, and E. P. Ivanova, , pp.1914-1954, 2011.

Y. A. Knirel, A. V. Perepelov, A. N. Kondakova, S. Y. Senchenkova, Z. Sidorczyk et al., strains, Innate Immunity, vol.62, issue.1, pp.70-96, 2011.
DOI : 10.1099/jmm.0.05161-0

A. V. Perepelov, M. E. Shekht, B. Liu, S. D. Shevelev, V. A. Ledov et al., FEMS Immunol Med Microbiol, vol.45, issue.66, pp.201-210, 2012.

R. Schauer, G. V. Srinivasan, D. Wipfler, B. Kniep, and R. Schwarz-albiez, The Molecular Immunology of Complex Carbohydrates-3, pp.525-548, 2011.

E. L. Deszo, S. M. Steenbergen, D. I. Freedberg, and E. R. Vimr, Escherichia coli K1 polysialic acid O-acetyltransferase gene, neuO, and the mechanism of capsule form variation involving a mobile contingency locus, Proceedings of the National Academy of Sciences, vol.210, issue.1, pp.5564-5569, 2005.
DOI : 10.1111/j.1432-1033.1992.tb17414.x

K. H. Blakeman, A. Weintraub, and G. Widmalm, Structural determination of the O-antigenic polysaccharide from the enterotoxigenic Escherichia coli O147, European Journal of Biochemistry, vol.251, issue.1-2, pp.534-537, 1998.
DOI : 10.1046/j.1432-1327.1998.2510534.x

C. Using, . Rsc, . R. Template-see-www, . Org, . Electronicfiles et al., VER. 3.1), pp.0-00

, This journal is © The Royal Society of Chemistry

V. L. L-'vov, A. P. Iakovlev, A. S. Shashkov, and B. A. Dmitriev, Bioorg Khim, vol.17, pp.111-120, 1991.

Y. A. Knirel, A. S. Shashkov, S. N. Senchenkova, S. Merino, and J. M. Tomas, Structure of the O-polysaccharide of Aeromonashydrophila O:34; a case of random O-acetylation of 6-deoxy-l-talose, Carbohydrate Research, vol.337, issue.15, pp.1381-1386, 2002.
DOI : 10.1016/S0008-6215(02)00136-2

M. R. King, S. M. Steenbergen, and E. R. Vimr, Going for baroque at the Escherichia coli K1 cell surface, Trends in Microbiology, vol.15, issue.5, pp.196-202, 2007.
DOI : 10.1016/j.tim.2007.03.006

A. L. Lewis, H. Cao, S. K. Patel, S. Diaz, W. Ryan et al., Journal of Biological Chemistry, vol.20, issue.38, pp.27562-27571, 2007.
DOI : 10.1111/j.1365-2958.1996.tb02641.x

J. Kubler-kielb, E. Vinogradov, C. Chu, and R. Schneerson, O-Acetylation in the O-specific polysaccharide isolated from Shigella flexneri serotype 2a, Carbohydrate Research, vol.342, issue.3-4, pp.643-647, 2007.
DOI : 10.1016/j.carres.2006.09.017

A. Molinaro, C. De-castro, B. O. Petersen, J. O. Duus, M. Parrilli et al.,

, Int Ed Engl, vol.39, pp.156-160, 2000.

A. V. Perepelov, V. L. Vov, B. Liu, S. Y. Senchenkova, M. E. Shekht et al., A similarity in the O-acetylation pattern of the O-antigens of Shigellaflexneri types 1a, 1b, and 2a, Carbohydrate Research, vol.344, issue.5, pp.687-692, 2009.
DOI : 10.1016/j.carres.2009.01.004

S. K. Gudlavalleti, A. K. Datta, Y. L. Tzeng, C. Noble, R. W. Carlson et al., Serogroup A Capsular Polysaccharide O-3 and O-4 Acetyltransferase, Journal of Biological Chemistry, vol.267, issue.41, pp.42765-42773, 2004.
DOI : 10.1128/JB.184.9.2379-2388.2002

T. Fiebig, F. Freiberger, V. Pinto, M. R. Romano, A. Black et al., Serogroup A, Journal of Biological Chemistry, vol.249, issue.28, pp.19395-19407, 2014.
DOI : 10.1074/jbc.M807518200

D. R. Bundle, I. C. Smith, and H. J. Jennings, J Biol Chem, vol.249, pp.2275-2281, 1974.

A. K. Bhattacharjee, H. J. Jennings, C. P. Kenny, A. Martin, and I. C. Smith, J Biol Chem, vol.20, issue.250, pp.1926-1932, 1975.

A. K. Bhattacharjee, H. J. Jennings, C. P. Kenny, A. Martin, and I. C. Smith, serogroups Y, W-135, and BO, Canadian Journal of Biochemistry, vol.54, issue.1, pp.1-8, 1976.
DOI : 10.1139/o76-001

A. K. Bergfeld, H. Claus, U. Vogel, and M. Muhlenhoff, K1, Journal of Biological Chemistry, vol.5, issue.30, pp.22217-22227, 2007.
DOI : 10.1074/jbc.M513772200

E. C. Schulz, A. K. Bergfeld, R. Ficner, M. Muhlenhoff, H. Claus et al., PLoS One Mol Microbiol, vol.51, pp.6-17403, 2004.

H. J. Lee, B. Rakic, M. Gilbert, W. W. Wakarchuk, S. G. Withers et al., Journal of Biological Chemistry, vol.14, issue.36, pp.24501-24511, 2009.
DOI : 10.1093/nar/22.22.4673

A. K. Bergfeld, H. Claus, N. K. Lorenzen, F. Spielmann, U. Vogel et al., -Acetyltransferases, Journal of Biological Chemistry, vol.268, issue.suppl., pp.6-16, 2009.
DOI : 10.1515/BC.2003.116

M. J. Cieslewicz, D. Chaffin, G. Glusman, D. Kasper, A. Madan et al., Structural and Genetic Diversity of Group B Streptococcus Capsular Polysaccharides, Infection and Immunity, vol.73, issue.5, pp.3096-3103, 2005.
DOI : 10.1128/IAI.73.5.3096-3103.2005

A. L. Lewis, V. Nizet, and A. Varki, Discovery and characterization of sialic acid O-acetylation in group B Streptococcus, Proceedings of the National Academy of Sciences, vol.66, issue.12, pp.11123-11128, 2004.
DOI : 10.1093/glycob/10.6.539

A. L. Lewis, M. E. Hensler, A. Varki, V. Nizet-lee, W. F. Vann et al., J Biol Chem 42. S. M. Steenbergen J Bacteriol, vol.281, issue.188, pp.11186-11192, 2006.

J. B. Robbins, G. H. Mccracken, E. C. Gotschlich, F. Ørskov, I. Ørskov et al., K1 Capsular Polysaccharide Associated with Neonatal Meningitis, New England Journal of Medicine, vol.290, issue.22, pp.1216-1220, 1974.
DOI : 10.1056/NEJM197405302902202

I. L. Mordhorst, H. Claus, C. Ewers, M. Lappann, C. Schoen et al., K1, Environmental Microbiology, vol.154, issue.12, pp.3154-3165, 2009.
DOI : 10.1128/jb.178.9.2527-2532.1996

R. Torensma, A. Vanwijk, M. J. Visser, A. Bouter, M. Rozenbergarska et al., J Clin Microbiol, vol.29, pp.1356-1358, 1991.

J. Colino, I. Outschoorn, and M. Pathogenesis, , pp.187-196, 1999.

H. Frasa, J. Procee, R. Torensma, A. Verbruggen, A. Algra et al., J Clin Microbiol, pp.31-3174, 1993.

, MMWR Morb Mortal Wkly Rep, vol.59, pp.109-112, 2009.

M. S. Edwards and C. J. Baker, Clin Infect Dis, vol.41, pp.839-847, 2005.

S. Weiman, S. Uchiyama, F. C. Lin, D. Chaffin, A. Varki et al., inhibits neutrophil suppression and virulence, Biochemical Journal, vol.27, issue.2, pp.163-168, 2010.
DOI : 10.1128/MMBR.68.1.132-153.2004

S. Weiman, S. Dahesh, A. F. Carlin, A. Varki, V. Nizet et al., Genetic and biochemical modulation of sialic acid O-acetylation on group B Streptococcus: Phenotypic and functional impact, Glycobiology, vol.275, issue.29, pp.1204-1213, 2009.
DOI : 10.1074/jbc.M002788200

C. M. Healy and C. J. Baker, , p.55

H. J. Jennings, C. Lugowski, and D. L. Kasper, Conformational aspects critical to the immunospecificity of the type III group B streptococcal polysaccharide, Biochemistry, vol.20, issue.16, pp.4511-4518, 1981.
DOI : 10.1021/bi00519a001

D. Safari, H. A. Dekker, G. T. Rijkers, A. Van-der-ende, J. P. Kamerling et al., The immune response to group B streptococcus type III capsular polysaccharide is directed to the -Glc-GlcNAc-Gal- backbone epitope, Glycoconjugate Journal, vol.262, issue.17, pp.557-562, 2011.
DOI : 10.1084/jem.149.2.327

, This journal is © The Royal Society of Chemistry

F. Carboni, R. Adamo, M. Fabbrini, R. De-ricco, V. Cattaneo et al., type III capsular polysaccharide, Proceedings of the National Academy of Sciences, vol.265, issue.19, pp.5017-5022
DOI : 10.1021/cb400423g

P. S. Pannaraj, M. S. Edwards, K. T. Ewing, A. L. Lewis, M. A. Rench et al., Group B streptococcal conjugate vaccines elicit functional antibodies independent of strain O-acetylation, Vaccine, vol.27, issue.33, pp.4452-4456, 2009.
DOI : 10.1016/j.vaccine.2009.05.039

C. Hyams, E. Camberlein, J. M. Cohen, K. Bax, and J. S. Brown, The Streptococcus pneumoniae Capsule Inhibits Complement Activity and Neutrophil Phagocytosis by Multiple Mechanisms, Infection and Immunity, vol.78, issue.2, pp.704-715, 2010.
DOI : 10.1128/IAI.00881-09

K. L. Wyres, L. M. Lambertsen, N. J. Croucher, L. Mcgee, A. Von-gottberg et al., Pneumococcal Capsular Switching: A Historical Perspective, Journal of Infectious Diseases, vol.14, issue.2, pp.439-449, 2013.
DOI : 10.3201/eid1402.070807

S. D. Bentley, D. M. Aanensen, A. Mavroidi, D. Saunders, E. Rabbinowitsch et al., Plos Genet, vol.2, pp.262-269, 2006.

J. J. Calix and M. H. Nahm, Gene, The Journal of Infectious Diseases, vol.202, issue.1, pp.29-38, 2010.
DOI : 10.1086/653123

J. J. Calix, M. H. Nahm, and E. R. Zartler, Elucidation of Structural and Antigenic Properties of Pneumococcal Serotype 11A, 11B, 11C, and 11F Polysaccharide Capsules, Journal of Bacteriology, vol.193, issue.19, pp.5271-5278, 2011.
DOI : 10.1128/JB.05034-11

X. Lemercinier and C. Jones, Full assignment of the 1H and 13C spectra and revision of the O-acetylation site of the capsular polysaccharide of Streptococcus pneumoniae Type 33F, a component of the current pneumococcal polysaccharide vaccine, Carbohydrate Research, vol.341, issue.1, pp.68-74, 2006.
DOI : 10.1016/j.carres.2005.10.014

J. Chang, Y. Serrano, R. Garrido, L. M. Rodriguez, J. Pedroso et al., Vaccine, vol.30, pp.2012-7090

J. J. Calix, J. S. Saad, A. M. Brady, and M. H. Nahm, in Serotype 9V Capsule Biosynthesis and Immunogenicity, Journal of Biological Chemistry, vol.66, issue.17, pp.13996-14003, 2012.
DOI : 10.1128/IAI.71.7.3875-3884.2003

T. J. Rutherford, C. Jones, D. B. Davies, and A. C. Elliott, Molecular recognition of antigenic polysaccharides: a conformational comparison of capsules from Streptococcus pneumonic?? serogroup 9, Carbohydrate Research, vol.265, issue.1, pp.97-117, 1994.
DOI : 10.1016/0008-6215(94)00212-6

T. J. Rutherford, C. Jones, D. B. Davies, and A. C. Elliott, Location and quantitation of the sites of O-acetylation on the capsular polysaccharide from Streptococcus pneumoniae type 9V by 1H-n.m.r. spectroscopy: comparison with type 9A, Carbohydrate Research, vol.218, pp.175-184, 1991.
DOI : 10.1016/0008-6215(91)84096-W

J. J. Calix, M. B. Oliver, L. K. Sherwood, B. Beall, S. K. Hollingshead et al., Streptococcus pneumoniae Serotype 9A Isolates Contain Diverse Mutations to wcjE That Result in Variable Expression of Serotype 9V-specific Epitope, The Journal of Infectious Diseases, vol.25, issue.10, pp.1585-1595, 2011.
DOI : 10.1097/01.inf.0000207484.52850.38

T. B. Mcneely, J. M. Staub, C. M. Rusk, M. J. Blum, and J. J. Donnelly, Infect Immun, vol.66, pp.25-3705, 1998.

J. J. Calix, A. M. Brady, V. Y. Du, J. S. Saad, and M. H. Nahm, Spectrum of Pneumococcal Serotype 11A Variants Results from Incomplete Loss of Capsule O-Acetylation, Journal of Clinical Microbiology, vol.52, issue.3, pp.758-765, 2014.
DOI : 10.1128/JCM.02695-13

J. J. Calix, R. Dagan, S. I. Pelton, N. Porat, and M. H. Nahm, Differential Occurrence of Streptococcus pneumoniae Serotype 11E Between Asymptomatic Carriage and Invasive Pneumococcal Disease Isolates Reflects a Unique Model of Pathogen Microevolution, Clinical Infectious Diseases, vol.108, issue.12, pp.794-799, 2012.
DOI : 10.1073/pnas.1016282108

R. Camilli, B. L. Spencer, M. Moschioni, V. Pinto, F. Berti et al., PLoS One, issue.9, p.100722, 2014.

A. M. Brady, J. J. Calix, J. Yu, K. A. Geno, G. R. Cutter et al., Low Invasiveness of Pneumococcal Serotype 11A Is Linked to Ficolin-2 Recognition of O-acetylated Capsule Epitopes and Lectin Complement Pathway Activation, The Journal of Infectious Diseases, vol.378, issue.7, pp.1155-1165, 2014.
DOI : 10.1016/S0140-6736(10)62225-8

F. L. Lin, E. Vinogradov, C. Deng, S. Zeller, B. A. Green et al., , p.35

, Carbohydr Res, vol.380, pp.101-107, 2013.

A. Mavroidi, D. M. Aanensen, D. Godoy, I. C. Skovsted, M. S. Kaltoft et al., Genetic Relatedness of the Streptococcus pneumoniae Capsular Biosynthetic Loci, Journal of Bacteriology, vol.189, issue.21, pp.7841-7855, 2007.
DOI : 10.1128/JB.00836-07

B. L. Spencer, J. S. Saad, A. T. Shenoy, C. J. Orihuela, and M. H. Nahm, Infect Immun, vol.85, pp.132-0011700132, 2017.

H. Peltola, Worldwide Haemophilus influenzae Type b Disease at the Beginning of the 21st Century: Global Analysis of the Disease Burden 25 Years after the Use of the Polysaccharide Vaccine and a Decade after the Advent of Conjugates, Clinical Microbiology Reviews, vol.13, issue.2, pp.302-317, 2000.
DOI : 10.1128/CMR.13.2.302-317.2000

M. Bröker, F. Berti, and P. Costantino, Human Vaccines Immunother, vol.12, pp.1808-1824, 2016.

J. T. Poolman, C. C. Peeters, and G. P. Van-den-dobbelsteen, The history of pneumococcal conjugate vaccine development: dose selection, Expert Review of Vaccines, vol.28, issue.14, pp.1379-1394, 2013.
DOI : 10.1097/INF.0b013e318199f8ef

DOI : 10.1084/jem.58.6.731

K. L. O-'brien, L. J. Wolfson, J. P. Watt, E. Henkle, M. Deloria-knoll et al., Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates, The Lancet, vol.374, issue.9693, pp.893-902, 2009.
DOI : 10.1016/S0140-6736(09)61204-6

D. M. Weinberger, R. Malley, and M. Lipsitch, Serotype replacement in disease after pneumococcal vaccination, The Lancet, vol.378, issue.9807, pp.1962-1973, 2011.
DOI : 10.1016/S0140-6736(10)62225-8

J. M. Skinner, L. Indrawati, J. Cannon, J. Blue, M. Winters et al., Vaccine, vol.50, pp.29-8870, 2011.

C. Jones and X. Lemercinier, Full NMR assignment and revised structure for the capsular polysaccharide from Streptococcus pneumoniae type 15B, Carbohydrate Research, vol.340, issue.3, pp.403-409, 2005.
DOI : 10.1016/j.carres.2004.12.009

P. E. Jansson, B. Lindberg, U. Lindquist, and J. Ljungberg, Structural studies of the capsular polysaccharide from Streptococcus pneumoniae types 15B and 15C, Carbohydrate Research, vol.162, issue.1, pp.111-116, 1987.
DOI : 10.1016/0008-6215(87)80205-7

B. L. Spencer, A. T. Shenoy, C. J. Orihuela, and M. H. Nahm, Clin Vaccine Immunol, vol.pii, pp.55-79, 2017.

B. Lindberg, J. Lonngren, and D. A. Powell, Structural studies on the specific type-14 pneumococcal polysaccharide, Carbohydrate Research, vol.58, issue.1, pp.177-186, 1977.
DOI : 10.1016/S0008-6215(00)83413-8

P. S. Venkateswaran, N. Stanton, and R. Austrian, Type Variation of Strains of Streptococcus pneumoniae in Capsular Serogroup 15, Journal of Infectious Diseases, vol.147, issue.6, pp.1041-1054, 1983.
DOI : 10.1093/infdis/147.6.1041

S. Van-selm, L. M. Van-cann, M. A. Kolkman, B. A. Van-der-zeijst, and J. P. Van-putten, Genetic Basis for the Structural Difference between Streptococcus pneumoniae Serotype 15B and 15C Capsular Polysaccharides, Infection and Immunity, vol.71, issue.11, pp.6192-6198, 2003.
DOI : 10.1128/IAI.71.11.6192-6198.2003

G. Rajam, G. M. Carlone, and S. Romero-steiner, Functional Antibodies to the O-Acetylated Pneumococcal Serotype 15B Capsular Polysaccharide Have Low Cross-Reactivities with Serotype 15C, Clinical and Vaccine Immunology, vol.14, issue.9, pp.1223-1227, 2007.
DOI : 10.1128/CVI.00184-07

C. Using, . Rsc, . R. Template-see-www, . Org, . Electronicfiles et al., VER. 3.1), pp.0-00

, This journal is © The Royal Society of Chemistry

M. R. Jacobs, C. E. Good, S. Bajaksouzian, and A. R. Windau, Serotypes 19A, 6C, and 22F and Serogroup 15 in Cleveland, Ohio, in Relation to Introduction of the Protein???Conjugated Pneumococcal Vaccine, Clinical Infectious Diseases, vol.97, issue.11, pp.1388-1395, 2008.
DOI : 10.1016/j.vaccine.2007.11.026

F. L. Lin, E. Vinogradov, C. Deng, S. Zeller, L. Phelan et al., Structure elucidation of capsular polysaccharides from Streptococcus pneumoniae serotype 33C, 33D, and revised structure of serotype 33B, Carbohydrate Research, vol.383, pp.97-104, 2014.
DOI : 10.1016/j.carres.2013.11.006

L. M. Beynon, J. C. Richards, and M. B. Perry, Identification of the Common Antigenic Determinant Shared by Streptococcus pneumoniae Serotypes 35A and 20 Capsular Polysaccharides - Structural Analysis of the Streptococcus pneumoniae Serotype 35A Capsular Polysaccharide, European Journal of Biochemistry, vol.61, issue.1, pp.163-167, 1997.
DOI : 10.1139/o83-026

J. J. Calix, R. J. Porambo, A. M. Brady, T. R. Larson, J. Yother et al., Serotype 20 Strains, Journal of Biological Chemistry, vol.3, issue.33, pp.27885-27894, 2012.
DOI : 10.1146/annurev.micro.62.081307.162944

L. M. Beynon, J. C. Richards, M. B. Perry, and P. J. Kniskern, Characterization of the capsular antigen of Streptococcus pneumoniae serotype 35B, Canadian Journal of Chemistry, vol.108, issue.1, pp.41-48, 1995.
DOI : 10.1021/ja00268a061

C. A. Bush, J. O. Cisar, and J. Yang, ABSTRACT, Journal of Bacteriology, vol.197, issue.17, pp.2762-2769, 2015.
DOI : 10.1128/JB.00207-15

K. A. Geno, J. S. Saad, and M. H. Nahm, ABSTRACT, Journal of Clinical Microbiology, vol.55, issue.5, pp.1416-1425, 2017.
DOI : 10.1128/JCM.00054-17

M. Staples, R. M. Graham, V. Hicks, J. Strachan, A. Gonçalves-da-silva et al., Discovery of Streptococcus pneumoniae serogroup 35 variants in Australian patients, Clinical Microbiology and Infection, vol.23, issue.7, pp.476-479, 2017.
DOI : 10.1016/j.cmi.2016.12.029

K. A. Geno, C. A. Bush, M. Wang, C. Jin, M. H. Nahm et al., ABSTRACT, Journal of Clinical Microbiology, vol.55, issue.9, pp.2775-2784, 2017.
DOI : 10.1128/JCM.00822-17

H. B. Konradsen, Validation of serotyping of Streptococcus pneumoniae in Europe, Vaccine, vol.23, issue.11, pp.1368-1373, 2005.
DOI : 10.1016/j.vaccine.2004.09.011

K. A. Geno, G. L. Gilbert, J. Y. Song, I. C. Skovsted, K. P. Klugman et al., Pneumococcal Capsules and Their Types: Past, Present, and Future, Clinical Microbiology Reviews, vol.28, issue.3, pp.871-899, 2015.
DOI : 10.1128/CMR.00024-15

M. I. Khan, R. L. Ochiai, and J. D. Clemens, Population impact of Vi capsular polysaccharide vaccine, Expert Review of Vaccines, vol.349, issue.5, pp.485-496, 2010.
DOI : 10.1056/NEJM200310023491423

C. M. Parry, T. T. Hien, G. Dougan, N. J. White, and J. J. Farrar, Typhoid Fever, New England Journal of Medicine, vol.347, issue.22, pp.1770-1782, 2002.
DOI : 10.1056/NEJMra020201

X. Hu, Z. Chen, K. Xiong, J. Wang, X. Rao et al., Vi capsular polysaccharide: Synthesis, virulence, and application, Critical Reviews in Microbiology, vol.79, issue.4, pp.440-452, 2017.
DOI : 10.1111/j.1348-0421.2001.tb01283.x

L. Kenne and A. A. Lindberg, Bacterial polysaccharides, p.315, 1981.

J. D. Robbins and J. B. Robbins, Reexamination of the Protective Role of the Capsular Polysaccharide (Vi antigen) of Salmonella typhi, Journal of Infectious Diseases, vol.150, issue.3, pp.436-449, 1984.
DOI : 10.1093/infdis/150.3.436

, European Pharmacopeia, pp.14-29, 1994.

S. Rijpkema, Z. Durrani, X. Lemercinier, and C. Jones, Detection of O-acetylated Vi polysaccharide of Salmonella enterica subspecies typhi by Enzyme Immunoassay, Biologicals, vol.32, issue.1, pp.11-16, 2004.
DOI : 10.1016/j.biologicals.2003.09.002

B. Szewczyk and A. Taylor, Infect Immun J Immunoassay, vol.29, issue.11, pp.539-544, 1980.

S. C. Szu, X. R. Li, A. L. Stone, and J. B. Robbins, Infect Immun S. C. Szu, Expert Rev Vaccines, vol.59, issue.12, pp.4555-4561, 1991.

S. Bystricky and S. C. Szu, O-acetylation affects the binding properties of the carboxyl groups on the Vi bacterial polysaccharide, Biophysical Chemistry, vol.51, issue.1, pp.1-7, 1994.
DOI : 10.1016/0301-4622(94)00002-6

A. Qadri, Identification of specific recognition molecules on murine mononuclear phagocytes and B lymphocytes for Vi capsular polysaccharide: modulation of MHC class II expression on stimulation with the polysaccharide, Immunology, vol.92, issue.1, pp.146-152, 1997.
DOI : 10.1046/j.1365-2567.1997.00315.x

C. Jones, NMR assays for carbohydrate-based vaccines, Journal of Pharmaceutical and Biomedical Analysis, vol.38, issue.5, pp.840-850, 2005.
DOI : 10.1016/j.jpba.2005.01.044

S. Hestrin, J Biol Chem, vol.180, pp.249-261, 1949.

X. Lemercinier, I. Martinez-cabrera, and C. Jones, Use and Validation of an NMR Test for the Identity and O -acetyl content of the Salmonella typhi Vi Capsular Polysaccharide Vaccine, Biologicals, vol.28, issue.1, pp.17-24, 2000.
DOI : 10.1006/biol.1999.0238

G. Kao and C. M. Tsai, Quantification of O-acetyl, N-acetyl and phosphate groups and determination of the extent of O-acetylation in bacterial vaccine polysaccharides by high-performance anion-exchange chromatography with conductivity detection (HPAEC-CD), Vaccine, vol.22, issue.3-4, pp.335-344, 2004.
DOI : 10.1016/j.vaccine.2003.08.008

S. Rondini, F. Micoli, L. Lanzilao, C. Hale, A. J. Saul et al., ABSTRACT, Clinical and Vaccine Immunology, vol.18, issue.3, pp.460-468, 2011.
DOI : 10.1128/CVI.00387-10

F. Micoli, S. Rondini, I. Pisoni, C. Giannelli, V. Di-cioccio et al., Production of a conjugate vaccine for Salmonella enterica serovar Typhi from Citrobacter Vi, Vaccine, vol.30, issue.5, pp.853-861, 2012.
DOI : 10.1016/j.vaccine.2011.11.108

W. Pilnik and A. G. , Voragen, in The biochemistry of fruits and their products, pp.53-87, 1970.

Z. Kossaczka, S. Bystricky, D. A. Bryla, J. Shiloach, J. B. Robbins et al., , p.45

, Immun, vol.65, pp.2088-2093, 1997.

S. C. Szu, K. F. Lin, S. Hunt, C. Chu, and N. D. Thinh, Phase I clinical trial of O-acetylated pectin conjugate, a plant polysaccharide based typhoid vaccine, Vaccine, vol.32, issue.22, pp.2618-2622, 2014.
DOI : 10.1016/j.vaccine.2014.03.023

D. Pace, Glycoconjugate vaccines, Expert Opinion on Biological Therapy, vol.33, issue.1, pp.11-33, 2013.
DOI : 10.1097/INF.0b013e31821038d9

Y. L. Tzeng, J. Thomas, and D. S. Stephens, Crit Rev Microbiol, vol.42, pp.759-772, 2016.

A. Villwock, C. Schmitt, M. Frosch, and O. Kurzai, Capsule acetylation does not impair recognition of serogroup C, W-135 and Y meningococci by human dendritic cells, International Journal of Medical Microbiology, vol.298, issue.7-8, pp.591-597, 2008.
DOI : 10.1016/j.ijmm.2007.11.003

M. A. Apicella and H. A. Feldman, Meningococcal Group C Subgroup Determinant Detected by Immunofluorescence, Experimental Biology and Medicine, vol.152, issue.3, pp.289-291, 1976.
DOI : 10.3181/00379727-152-39381

R. Borrow, E. Longworth, S. J. Gray, and E. B. Kaczmarski, -acetylated serogroup C meningococci before the introduction of meningococcal serogroup C conjugate vaccines in the United Kingdom, FEMS Immunology & Medical Microbiology, vol.15, issue.Suppl., pp.189-191, 2000.
DOI : 10.1093/infdis/152.4.850

G. Arakere and C. E. Frasch, Infect Immun, vol.59, pp.4349-4356, 1991.

M. P. Glode, E. B. Lewin, A. Sutton, C. T. Le, E. C. Gotschlich et al., J Infect, p.55

, Dis, vol.139, pp.52-59, 1979.

M. C. Steinhoff, E. B. Lewin, E. C. Gotschlich, and J. B. Robbins, Infect Immun, vol.34, pp.144-146, 1981.

I. Vodopija, Z. Baklaic, P. Hauser, P. Roelants, F. E. André et al., Infect Immun, vol.42, pp.599-604, 1983.

H. Peltola, A. Safary, H. Kayhty, V. Karanko, and F. E. Andre, Pediatrics This journal is © The Royal Society of Chemistry, vol.76, pp.91-96, 1985.

P. Richmond, D. Goldblatt, P. C. Fusco, J. D. Fusco, I. Heron et al., Safety and immunogenicity of a new Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine in healthy adults, Vaccine, vol.18, issue.7-8, pp.641-646, 1999.
DOI : 10.1016/S0264-410X(99)00276-5

P. Richmond, R. Borrow, J. Findlow, S. Martin, C. Thornton et al., Evaluation of De-O-Acetylated Meningococcal C Polysaccharide-Tetanus Toxoid Conjugate Vaccine in Infancy: Reactogenicity, Immunogenicity, Immunologic Priming, and Bactericidal Activity against O-Acetylated and De-O-Acetylated Serogroup C Strains, Infection and Immunity, vol.69, issue.4, pp.2378-2382, 2001.
DOI : 10.1128/IAI.69.4.2378-2382.2001

F. Michon, C. H. Huang, E. K. Farley, L. Hronowski, J. Di et al., Dev Biol, vol.5, issue.103, pp.151-160, 2000.

P. C. Fusco, E. K. Farley, C. Huang, S. Moore, and F. Michon, Protective Meningococcal Capsular Polysaccharide Epitopes and the Role of O Acetylation, Clinical and Vaccine Immunology, vol.14, issue.5, pp.577-584, 2007.
DOI : 10.1128/CVI.00009-07

P. Richmond, R. Borrow, D. Goldblatt, J. Findlow, S. Martin et al., Ability of 3 Different Meningococcal C Conjugate Vaccines to Induce Immunologic Memory after a Single Dose in UK Toddlers, The Journal of Infectious Diseases, vol.183, issue.1, pp.160-163, 2001.
DOI : 10.1086/317646

P. Balmer, R. Borrow, and E. Miller, Impact of meningococcal C conjugate vaccine in the UK, Journal of Medical Microbiology, vol.51, issue.9, pp.717-722, 2002.
DOI : 10.1099/0022-1317-51-9-717

M. M. Ho, X. Lemercinier, B. Bolgiano, D. Crane, and M. J. , Solution stability studies of the subunit components of meningococcal C oligosaccharide???CRM197 conjugate vaccines, Biotechnology and Applied Biochemistry, vol.33, issue.2, pp.91-98, 2001.
DOI : 10.1042/BA20000078

C. Jones and X. Lemercinier, Use and validation of NMR assays for the identity and O-acetyl content of capsular polysaccharides from Neisseria meningitidis used in vaccine manufacture, Journal of Pharmaceutical and Biomedical Analysis, vol.30, issue.4, pp.1233-1247, 2002.
DOI : 10.1016/S0731-7085(02)00462-4

A. Bardotti, G. Averani, F. Berti, S. Berti, V. Carinci et al.,

C. Giannozzi, D. Magagnoli, F. Proietti, R. Norelli, S. Rappuoli et al., Vaccine, vol.26, pp.2284-2296, 2008.

C. Vipond, C. J. Swann, T. W. Dougall, P. Rigsby, F. Gao et al., Evaluation of candidate international standards for meningococcal serogroups A and X polysaccharide, Biologicals, vol.47, pp.33-45, 2017.
DOI : 10.1016/j.biologicals.2017.03.001

E. Longworth, P. Fernsten, T. L. Mininni, U. Vogel, H. Claus et al., , p.20

, Borrow FEMS Immunol Med Microbiol, vol.32, pp.119-123, 2002.

M. M. Kuttel, Z. Timol, and N. Ravenscroft, Carbohydr Res, vol.2017, pp.446-447

J. M. Griffiss, B. L. Brandt, P. L. Altieri, G. B. Pier, and S. L. Berman, Infect Immun, vol.34, pp.725-732, 1981.

M. Leonardi, T. Latiolais, K. Sarpong, M. Simon, J. Twiggs et al., , p.25

V. Blatter, Y. Bianco, L. R. Baine, J. M. Friedland, and . Miller, Vaccine, vol.33, pp.933-941, 2015.

S. K. Gudlavalleti, C. H. Lee, S. E. Norris, M. Paul-satyaseela, W. F. Vann et al., Comparison of Neisseria meningitidis serogroup W135 polysaccharide???tetanus toxoid conjugate vaccines made by periodate activation of O-acetylated, non-O-acetylated and chemically de-O-acetylated polysaccharide, Vaccine, vol.25, issue.46, pp.7972-7980, 2007.
DOI : 10.1016/j.vaccine.2007.06.018

P. C. Giardina, E. Longworth, R. E. Evans-johnson, M. L. Bessette, H. Zhang et al., , pp.586-592, 2005.

Z. G. Jin, G. A. Bohach, J. Shiloach, S. E. Norris, D. I. Freedberg et al., Conjugates of Group A and W135 Capsular Polysaccharides of Neisseria meningitidis Bound to Recombinant Staphylococcus aureus Enterotoxin C1: Preparation, Physicochemical Characterization, and Immunological Properties in Mice, Infection and Immunity, vol.73, issue.12, pp.7887-7893, 2005.
DOI : 10.1128/IAI.73.12.7887-7893.2005

S. K. Gudlavalleti, C. M. Szymanski, H. C. Jarrell, and D. S. Stephens, In vivo determination of Neisseria meningitidis serogroup A capsular polysaccharide by whole cell high-resolution magic angle spinning NMR spectroscopy, Carbohydrate Research, vol.341, issue.4, pp.557-562, 2006.
DOI : 10.1016/j.carres.2005.11.036

D. S. Berry, F. Lynn, C. H. Lee, C. E. Frasch, and M. C. Bash, Effect of O Acetylation of Neisseria meningitidis Serogroup A Capsular Polysaccharide on Development of Functional Immune Responses, Infection and Immunity, vol.70, issue.7, pp.3707-3742, 2002.
DOI : 10.1128/IAI.70.7.3707-3713.2002

C. E. Frasch, M. P. Preziosi, and F. M. Laforce, Human Vaccines & Immunotherapeutics, vol.9, issue.6, pp.715-724, 2012.
DOI : 10.1002/sim.4780091208

C. E. Frasch, S. V. Kapre, C. H. Lee, and J. M. Preaud, Clin Infect Dis, pp.61-404, 2015.

C. H. Lee, W. C. Kuo, S. Beri, S. Kapre, J. S. Joshi et al., , p.40

V. Frasch, , pp.726-732, 2009.