Frequent infection of Hylobates pileatus (pileated gibbon) with species-associated variants of hepatitis B virus in Cambodia

A. A. Sall (1) , S. Starkman (2) , Jean-Marc Reynes (1) , S. Lay (1) , T. Nhim (3) , M. Hunt (4) , N. Marx (4) , Peter Simmonds (2)

1 Institut Pasteur du Cambodge
2 University of Edinburgh
3 Phnom Tamao Wildlife Rescue Center
4 WildAid Cambodia

As well as being distributed widely in human populations, hepatitis B virus (HBV) infections occur frequently in chimpanzee, gibbon and other ape populations in sub-Saharan Africa and South-East Asia. To investigate the frequency and genetic relationships of HBV infecting gibbons in Cambodia, pileated gibbons (Hylobates pileatus) that were originally wild-caught were screened for surface antigen. Twelve of 26 (46 %) were positive, of which 11 were positive for HBV DNA. Phylogenetic analysis of complete genome sequences revealed two distinct genetic groups in the gibbon/orangutan clade. Three were similar to previously described variants infecting H. pileatus in Thailand and eight formed a distinct clade, potentially representing distinct strains of HBV circulating in geographically separated populations in South-East Asia. Because of the ability of HBV to cross species barriers, large reservoirs of infection in gibbons may hamper ongoing attempts at permanent eradication of HBV infection from human populations in South-East Asia through immunization.

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Animal biology; Veterinary medicine and animal Health; Life Sciences [q-bio]; Microbiology and Parasitology; Virology; Life Sciences [q-bio]; Human health and pathology; Infectious diseases; Life Sciences [q-bio]; Santé publique et épidémiologie

A. A. Sall, S. Starkman, Jean-Marc Reynes, S. Lay, T. Nhim, et al.. Frequent infection of Hylobates pileatus (pileated gibbon) with species-associated variants of hepatitis B virus in Cambodia. Journal of General Virology, 2005, 86 (2), pp.333 - 337. ⟨10.1099/vir.0.80274-0⟩. ⟨pasteur-01836614⟩