Immunosuppression and GB virus C-RNA detection among HIV-infected patients in Cambodia

Amadou Alpha Sall (1) , Olivier Ségéral (2, 3) , Jean-Marc Reynes (1) , Sreyrath Lay (1) , Vara Ouk (1) , Chan Roeun Hak (2) , Cheng Lay Keo (2) , Robin Lefait (2) , Jean-François Delfraissy (2, 3) , Arnaud Fontanet (4)

1 Institut Pasteur du Cambodge
2 Calmette Hospital [Phnom Penh]
3 AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)
4 Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology

In this survey, 213 patients in an antiretroviral treatment programme in Phnom Penh, Cambodia, were tested for GB virus C (GBV-C) RNA before treatment initiation. Most had advanced HIV infection, only 34 having CD4 cell counts > 200 cells/microl. GBV-C-RNA was detected in 35 patients. The proportion with positive GBV-C-RNA decreased dramatically with CD4 cell counts < 100 cells/microl. In multivariate analysis, low CD4 cell counts, tuberculosis, anaemia, and traditional medicine were independently and negatively associated with GBV-C-RNA detection.

Domains: Life Sciences [q-bio]; Human health and pathology; Infectious diseases; Life Sciences [q-bio]; Microbiology and Parasitology; Virology

Amadou Alpha Sall, Olivier Ségéral, Jean-Marc Reynes, Sreyrath Lay, Vara Ouk, et al.. Immunosuppression and GB virus C-RNA detection among HIV-infected patients in Cambodia. AIDS. Official journal of the international AIDS Society, 2006, 20 (8), pp.1199 - 1201. ⟨10.1097/01.aids.0000226962.33213.57⟩. ⟨pasteur-01836535⟩