D. Watson, M. Sargianou, A. Papa, P. Chra, I. Starakis et al., Epidemiology of Hantavirus infections in humans: A comprehensive, global overview, Critical Reviews in Microbiology, vol.36, issue.3, pp.261-72, 2014.
DOI : 10.3201/eid1608.090470

A. Vaheri, H. Henttonen, L. Voutilainen, J. Mustonen, T. Sironen et al., Hantavirus infections in Europe and their impact on public health, Reviews in Medical Virology, vol.109, issue.28, pp.35-49, 2013.
DOI : 10.1016/j.biosystemseng.2011.02.004

O. Vapalahti, J. Mustonen, A. Lundkvist, H. Henttonen, A. Plyusnin et al., Hantavirus Infections in Europe, The Lancet Infectious Diseases, vol.3, issue.10, pp.653-61, 2003.
DOI : 10.1016/S1473-3099(03)00774-6

I. Pasteur, Rapports d'activité, 2016.

C. Strady, R. Jaussaud, R. G. Penalba, and C. , Hantavirus infections [in French], Presse Med, vol.34, pp.391-400, 2005.

M. Hjertqvist, S. Klein, C. Ahlm, and J. Klingstrom, Mortality Rate Patterns for Hemorrhagic Fever with Renal Syndrome Caused by Puumala Virus, Emerging Infectious Diseases, vol.16, issue.10, pp.1584-1590, 2010.
DOI : 10.3201/eid1610.100242
URL : https://wwwnc.cdc.gov/eid/article/16/10/pdfs/10-0242.pdf

M. Miettinen, S. Mäkelä, I. Ala-houhala, H. Huhtala, T. Kööbi et al., Ten-year prognosis of Puumala hantavirus-induced acute interstitial nephritis, Kidney International, vol.69, issue.11, pp.2043-2051, 2006.
DOI : 10.1038/sj.ki.5000334
URL : https://doi.org/10.1038/sj.ki.5000334

N. Braun, M. Haap, D. Overkamp, M. Kimmel, M. Alscher et al., Characterization and outcome following Puumala virus infection: a retrospective analysis of 75 cases, Nephrology Dialysis Transplantation, vol.10, issue.8, pp.2997-3003, 2010.
DOI : 10.3201/eid1008.031069

T. Outinen, S. Mäkelä, J. Clement, A. Paakkala, I. Pörsti et al., Community Acquired Severe Acute Kidney Injury Caused by Hantavirus-Induced Hemorrhagic Fever with Renal Syndrome Has a Favorable Outcome, Nephron, vol.130, issue.3, pp.182-90, 2015.
DOI : 10.1159/000433563

P. Makary, M. Kanerva, J. Ollgren, M. Virtanen, O. Vapalahti et al., Disease burden of Puumala virus infections, 1995???2008, Epidemiology and Infection, vol.318, issue.10, pp.1484-92, 1995.
DOI : 10.1016/j.epidem.2009.03.002

J. Latus, M. Schwab, E. Tacconelli, F. Pieper, D. Wegener et al., Clinical Course and Long-Term Outcome of Hantavirus-Associated Nephropathia Epidemica, Germany, Emerging Infectious Diseases, vol.21, issue.1, pp.76-83, 2015.
DOI : 10.3201/eid2101.140861

H. Bunz, P. Weyrich, A. Peter, D. Baumann, O. Tschritter et al., Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) and proteinuria predict severity of acute kidney injury in Puumala virus infection, BMC Infectious Diseases, vol.7, issue.1, p.464, 2015.
DOI : 10.1371/journal.pone.0035402

J. Latus, M. Schwab, E. Tacconelli, F. Pieper, D. Wegener et al., Acute kidney injury and tools for risk-stratification in 456 patients with hantavirus-induced nephropathia epidemica, Nephrology Dialysis Transplantation, vol.9, issue.9, pp.245-51, 2015.
DOI : 10.1371/journal.pone.0098397

S. Mäkelä, M. Hurme, I. Ala-houhala, J. Mustonen, A. Koivisto et al., Polymorphism of the cytokine genes in hospitalized patients with Puumala hantavirus infection, Nephrology Dialysis Transplantation, vol.16, issue.7, pp.1368-73, 2001.
DOI : 10.1093/hmg/1.5.353

R. Bellomo, C. Ronco, J. Kellum, R. Mehta, and P. Palevsky, Acute Dialysis Quality Initiative workgroup Acute renal failure? definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) group, Critical Care, vol.8, issue.4, pp.204-216, 2004.
DOI : 10.1186/cc2872

, Kidney Disease: Improving Global Outcomes Acute Kidney Injury Work Group. KDIGO clinical practice guideline for acute kidney injury, Kidney Int Suppl, vol.2, pp.1-138, 2012.

R. Mehta, J. Kellum, S. Shah, B. Molitoris, C. Ronco et al., Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury, Critical Care, vol.11, issue.2, p.31, 2007.
DOI : 10.1186/cc5713

H. Quan, B. Li, C. Couris, K. Fushimi, P. Graham et al., Updating and Validating the Charlson Comorbidity Index and Score for Risk Adjustment in Hospital Discharge Abstracts Using Data From 6 Countries, American Journal of Epidemiology, vol.33, issue.4, pp.676-82, 2011.
DOI : 10.2307/2529310

L. Tervo, S. Mäkelä, J. Syrjänen, R. Huttunen, A. Rimpelä et al., Smoking is associated with aggravated kidney injury in Puumala hantavirus-induced haemorrhagic fever with renal syndrome, Nephrology Dialysis Transplantation, vol.34, issue.10, pp.1693-1701, 2015.
DOI : 10.1371/journal.pone.0035402
URL : https://academic.oup.com/ndt/article-pdf/30/10/1693/6908178/gfv273.pdf

S. Klein, M. Marks, W. Li, G. Glass, L. Fang et al., Sex differences in the incidence and case fatality rates from hemorrhagic fever with renal syndrome in China No gender-related differences in the severity of nephropathia epidemica, Clin Infect Dis. BMC Infect Dis, vol.5213, pp.1414-214571471, 2004.

H. Du, P. Wang, J. Li, L. Bai, H. Li et al., Clinical characteristics and outcomes in critical patients with hemorrhagic fever with renal syndrome, BMC Infectious Diseases, vol.80, issue.4, pp.1471-2334, 0191.
DOI : 10.1002/1096-9071(200103)63:3<247::AID-JMV1008>3.0.CO;2-F

R. Wagner, U. Leicht-biener, I. Mucsi, and K. Seitz, Ibuprofen or diclofenac is associated with more severe acute kidney injury in nephropathia epidemica, Scandinavian Journal of Urology and Nephrology, vol.11, issue.2, pp.65-74, 2012.
DOI : 10.1186/cc5713

N. Hautala, H. Kauma, S. Rajaniemi, T. Sironen, O. Vapalahti et al., Signs of general inflammation and kidney function are associated with the ocular features of acute Puumala hantavirus infection, Scandinavian Journal of Infectious Diseases, vol.4, issue.12, pp.956-62, 2012.
DOI : 10.1097/MEG.0b013e3282f2468d

G. Theiler, B. Langer-wegscheider, I. Zollner-schwetz, T. Valentin, M. Hönigl et al., Blurred vision and myopic shift in Puumala virus infections are independent of disease severity, Clinical Microbiology and Infection, vol.18, issue.10, pp.435-442, 2012.
DOI : 10.1111/j.1469-0691.2012.03997.x

N. Hautala, H. Kauma, O. Vapalahti, S. Mähönen, O. Vainio et al., Prospective study on ocular findings in acute Puumala hantavirus infection in hospitalised patients

, Br J Ophthalmol, vol.95, pp.559-62, 2011.

S. Skarphedinsson, H. Thiesson, S. Shakar, and M. Tepel, Factors predicting kidney damage in Puumala virus infected patients in Southern Denmark, European Journal of Clinical Microbiology & Infectious Diseases, vol.10, issue.10, pp.2017-2038, 2015.
DOI : 10.3201/eid1008.031069

T. Outinen, P. Mantula, O. Laine, I. Pörsti, A. Vaheri et al., Haematuria is a marker for the severity of acute kidney injury but does not associate with thrombocytopenia in acute Puumala hantavirus infection, Infectious Diseases, vol.34, issue.11-12, pp.840-846, 2017.
DOI : 10.3109/00365549509047057

J. Latus, D. Kitterer, J. Dippon, S. Müller, F. Artunc et al., Polyuria in Hantavirus Infection Reflects Disease Severity and Is Associated with Prolonged Hospital Stay: A Systematic Analysis of 335 Patients from Southern Germany, Nephron Experimental Nephrology, vol.128, issue.3-4, pp.111-116, 2014.
DOI : 10.1159/000368934

Y. Kim, S. Lee, C. Kim, S. Heo, C. Choi et al., Clinical and laboratory predictors of oliguric renal failure in haemorrhagic fever with renal syndrome caused by Hantaan virus, Journal of Infection, vol.54, issue.4, pp.381-387, 2007.
DOI : 10.1016/j.jinf.2006.07.006

M. Wang, J. Wang, T. Wang, J. Li, L. Hui et al., Thrombocytopenia as a Predictor of Severe Acute Kidney Injury in Patients with Hantaan Virus Infections, PLoS ONE, vol.1, issue.1, p.53236, 2013.
DOI : 10.1371/journal.pone.0053236.t003

D. Libraty, S. Mäkelä, J. Vlk, M. Hurme, A. Vaheri et al., The Degree of Leukocytosis and Urine GATA-3 mRNA Levels Are Risk Factors for Severe Acute Kidney Injury in Puumala Virus Nephropathia Epidemica, PLoS ONE, vol.111, issue.4, p.35402, 2012.
DOI : 10.1371/journal.pone.0035402.t003

H. Du, J. Li, H. Yu, W. Jiang, Y. Zhang et al., Abstract, Clinical Chemistry and Laboratory Medicine (CCLM), vol.0, issue.0, pp.1667-75, 2014.
DOI : 10.1515/cclm-2014-0016
URL : https://hal.archives-ouvertes.fr/hal-00007529

H. Du, J. Li, H. Yu, J. Lian, Y. Zhang et al., HMGB-1 as a Novel Predictor of Disease Severity and Prognosis in Patients with Hemorrhagic Fever with Renal Syndrome, Mediators of Inflammation, vol.40, issue.35, p.696248696248, 2015.
DOI : 10.3346/jkms.2003.18.5.696

T. Outinen, S. Mäkelä, I. Ala-houhala, H. Huhtala, M. Hurme et al., The severity of Puumala hantavirus induced nephropathia epidemica can be better evaluated using plasma interleukin-6 than C-reactive protein determinations, BMC Infectious Diseases, vol.351, issue.Pt 3, p.132, 2010.
DOI : 10.1016/j.cccn.2004.08.018

J. Latus, D. Kitterer, S. Segerer, F. Artunc, M. Alscher et al., Severe thrombocytopenia in hantavirus-induced nephropathia epidemica, Infection, vol.10, issue.1, pp.83-90, 2015.
DOI : 10.1186/1471-2334-10-132

F. Rasche, B. Uhel, R. Ulrich, D. Krüger, W. Karges et al., Thrombocytopenia and Acute Renal Failure in Puumala Hantavirus Infections, Emerging Infectious Diseases, vol.10, issue.8, pp.1420-1425, 2004.
DOI : 10.3201/eid1008.031069

D. Tur?inov, I. Puljiz, A. Markoti?, I. Kuzman, and J. Begovac, Clinical and laboratory findings in patients with oliguric and non-oliguric Hantavirus haemorrhagic fever with renal syndrome: an analysis of 128 patients, Clinical Microbiology and Infection, vol.19, issue.7
DOI : 10.1111/j.1469-0691.2012.03994.x

P. Mantula, T. Outinen, J. Clement, H. Huhtala, I. Pörsti et al., Glomerular Proteinuria Predicts the Severity of Acute Kidney Injury in Puumala Hantavirus-Induced Tubulointerstitial Nephritis, Nephron, vol.136, issue.3, pp.193-201, 2017.
DOI : 10.1159/000459634

J. Mustonen, S. Mäkelä, T. Outinen, O. Laine, J. Jylhävä et al., The pathogenesis of nephropathia epidemica: New knowledge and unanswered questions, Antiviral Research, vol.100, issue.3, pp.589-604, 2013.
DOI : 10.1016/j.antiviral.2013.10.001

T. Hautala, T. Partanen, T. Sironen, S. Rajaniemi, N. Hautala et al., Elevated Cerebrospinal Fluid Neopterin Concentration Is Associated with Disease Severity in Acute Puumala Hantavirus Infection, Clinical and Developmental Immunology, vol.33, issue.8, p.634632634632, 2013.
DOI : 10.1186/1471-2334-11-217
URL : http://doi.org/10.1155/2013/634632

J. Mustonen, J. Partanen, M. Kanerva, K. Pietilä, O. Vapalahti et al., Genetic susceptibility to severe course of nephropathia epidemica caused by Puumala hantavirus, Kidney International, vol.49, issue.1, pp.217-2129, 1996.
DOI : 10.1038/ki.1996.29

, Address for correspondence: Maxime Hentzien, Service de Médecine Interne

R. Debré and A. Du, Général Koenig 51092 Reims, France; email: mhentzien@chu-reims.fr ? Fatal Outbreak in Tonkean Macaques Caused by Possibly Novel Orthopoxvirus, Italy, 2015.

, ? Spread of Canine Influenza A(H3N2) Virus, United States ? Evolutionary Context of Non?Sorbitol-Fermenting Shiga Toxin?Producing Escherichia coli O55, p.7