Control of pathogens and microbiota by innate lymphoid cells

Sascha Cording (1) , Jasna Medvedovic (1) , Emelyne Lecuyer (2, 1) , Tegest Aychek (1) , Gerard Eberl (1)

1 Microenvironnement et Immunité - Microenvironment and Immunity
2 IMAGINE - U1163 - Imagine - Institut des maladies génétiques

Innate lymphoid cells (ILCs) are the innate counterpart of T cells. Upon infection or injury, ILCs react promptly to direct the developing immune response to the one most adapted to the threat facing the organism. Therefore, ILCs play an important role early in resistance to infection, but also to maintain homeostasis with the symbiotic microbiota following perturbations induced by diet and pathogens. Such roles of ILCs have been best characterized in the intestine and lung, mucosal sites that are exposed to the environment and are therefore colonized with diverse but specific types of microbes. Understanding the dialogue between pathogens, microbiota and ILCs may lead to new strategies to re-inforce immunity for prevention, vaccination and therapy.

Keywords: Innate lymphoid cells; Homeostasis; Microbiota; Mucosal immunity; Pathogens

Domains: Innate immunity

Sascha Cording, Jasna Medvedovic, Emelyne Lecuyer, Tegest Aychek, Gerard Eberl. Control of pathogens and microbiota by innate lymphoid cells. Microbes and Infection, 2018, ⟨10.1016/j.micinf.2018.05.003⟩. ⟨pasteur-01824045⟩