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, SCIENTIFIC RePoRTS |, vol.8, 2018.

, Man.V. supervised the laboratory testing and reviewed the submitted manuscript. S.R. recruited and managed patients, and reviewed the submitted manuscript. G.P. performed the sequencing, and reviewed the submitted manuscript. M.L. has jointly had overall responsibility and direction of the SEAe study, and reviewed the submitted manuscript. C.G. has jointly had overall responsibility and direction of the SEAe study, and reviewed the submitted manuscript provided the clinical datasets, has jointly had overall responsibility and direction of the SEAe study, and reviewed the submitted manuscript. P.N.N. conceived the concept and design of the study, has jointly had overall responsibility and direction of the SEAe study, supervised drafting and submission of the manuscript, laboratory testing, and reviewed the submitted manuscript. Mal.V. performed the laboratory testing, and reviewed the submitted manuscript X.D.L. conceived the concept and design of the study, has jointly had overall responsibility and direction of the SEAe study, and reviewed the submitted manuscript. A.D.P. conceived the concept and design of the study, supervised the laboratory testing, has jointly had overall responsibility and direction of the SEAe study, supervised drafting and submission of the manuscript