binary toxin CDT, Gut Microbes, vol.56, issue.1, pp.15-27, 2014. ,
DOI : 10.1099/jmm.0.031062-0
URL : https://www.tandfonline.com/doi/pdf/10.4161/gmic.26854?needAccess=true
Fluid accumulation in the ligated intestinal loop and histopathological changes of the intestinal mucosa caused by Clostridium botulinum C2 toxin in the pheasant and chicken, Res. Vet. Sci, vol.42, pp.349-353, 1987. ,
Lethal and vascular permeability activities of botulinum C2 toxin induced by separate injections of the two toxin components, Infect. Immun, vol.40, pp.336-339, 1983. ,
Clostridial enteric diseases of domestic animals, Clin. Microbiol. Rev, vol.9, pp.216-234, 1996. ,
Botulinum C2 toxin ADP-ribosylates actin, Nature, vol.85, issue.6077, pp.390-392, 1986. ,
DOI : 10.1038/322390a0
Actin-specific ADP-ribosyltransferase produced by a Clostridium difficile strain, Infect. Immun, vol.56, pp.2299-2306, 1988. ,
ADP-ribosylation of skeletal muscle and non-muscle actin by Clostridium perfringens iota toxin, European Journal of Biochemistry, vol.247, issue.1-2, pp.225-229, 1988. ,
DOI : 10.1042/bj2470363
Mechanisms of the cytopathic action of actin-ADP-ribosylating toxins, Molecular Microbiology, vol.267, issue.20, pp.2905-2908, 1992. ,
DOI : 10.1083/jcb.109.2.593
ADP-ribosylation of actin causes increase in the rate of ATP exchange and inhibition of ATP hydrolysis, European Journal of Biochemistry, vol.261, issue.1, pp.229-232, 1989. ,
DOI : 10.1083/jcb.105.4.1473
Botulinum C2 toxin ADP-ribosylates actin and disorganizes the microfilament network in intact cells, Eur. J. Cell Biol, vol.43, pp.134-140, 1987. ,
ADP-ribosylated actin caps the barbed ends of actin filaments, J. Biol. Chem, vol.263, pp.13739-13742, 1988. ,
Functional Characterization of an Extended Binding Component of the Actin-ADP-Ribosylating C2 Toxin Detected in Clostridium botulinum Strain (C) 2300, Infection and Immunity, vol.78, issue.4, pp.1468-1474, 2010. ,
DOI : 10.1128/IAI.01351-09
C2 Toxin Requires Oligomerization and Acidification, Journal of Biological Chemistry, vol.266, issue.25, pp.18704-18711, 2000. ,
DOI : 10.1038/385833a0
URL : http://www.jbc.org/content/275/25/18704.full.pdf
The C Terminus of Component C2II of Clostridium botulinum C2 Toxin Is Essential for Receptor Binding, Infection and Immunity, vol.68, issue.8, pp.4566-4573, 2000. ,
DOI : 10.1128/IAI.68.8.4566-4573.2000
C2 Toxin to Asparagine-linked Complex and Hybrid Carbohydrates, Journal of Biological Chemistry, vol.266, issue.4, pp.2328-2334, 2000. ,
DOI : 10.1146/annurev.ge.18.120184.002521
URL : http://www.jbc.org/content/275/4/2328.full.pdf
toxin on tissue-culture cells, FEMS Microbiology Letters, vol.10, issue.2-3, pp.281-284, 1984. ,
DOI : 10.1038/newbio243246a0
, Biochemistry, vol.42, issue.51, pp.15284-15291, 2003.
DOI : 10.1021/bi0354278
Structure and Action of the Binary C2 Toxin from Clostridium botulinum, Journal of Molecular Biology, vol.364, issue.4, pp.705-715, 2006. ,
DOI : 10.1016/j.jmb.2006.09.002
Binary Actin-ADP-Ribosylating Toxins and their Use as Molecular Trojan Horses for Drug Delivery into Eukaryotic Cells, Current Medicinal Chemistry, vol.15, issue.5, pp.459-469, 2008. ,
DOI : 10.2174/092986708783503195
Purification and characterization of Clostridium perfringens iota toxin: dependence on two nonlinked proteins for biological activity, Infect. Immun, vol.54, pp.683-688, 1986. ,
Binary Bacterial Toxins: Biochemistry, Biology, and Applications of Common Clostridium and Bacillus Proteins, Microbiology and Molecular Biology Reviews, vol.68, issue.3, pp.373-402, 2004. ,
DOI : 10.1128/MMBR.68.3.373-402.2004
Production of a complete binary toxin (actin-specific ADPribosyltransferase ) by Clostridium difficile CD196, Infect. Immun, vol.65, pp.1402-1407, 1997. ,
Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT), Proc. Natl. Acad. Sci. USA, pp.16422-16427, 2011. ,
DOI : 10.1128/IAI.69.5.2980-2987.2001
Clostridium difficile Binary Toxin CDT Induces Clustering of the Lipolysis-Stimulated Lipoprotein Receptor into Lipid Rafts, mBio, vol.4, issue.3, pp.244-00213, 2013. ,
DOI : 10.1128/mBio.00244-13
CD44 Promotes Intoxication by the Clostridial Iota-Family Toxins, PLoS ONE, vol.163, issue.12, 2012. ,
DOI : 10.1371/journal.pone.0051356.g004
URL : https://hal.archives-ouvertes.fr/pasteur-01764029
Cyclophilin-Facilitated Membrane Translocation as Pharmacological Target to Prevent Intoxication of Mammalian Cells by Binary Clostridial Actin ADP-Ribosylated Toxins, Journal of Molecular Biology, vol.427, issue.6, pp.1224-1238, 2015. ,
DOI : 10.1016/j.jmb.2014.07.013
URL : https://hal.archives-ouvertes.fr/pasteur-01768428
C2 Toxin into the Cytosol, Journal of Biological Chemistry, vol.269, issue.34, pp.32266-32274, 2003. ,
DOI : 10.1083/jcb.200210028
The Host Cell Chaperone Hsp90 Is Necessary for Cytotoxic Action of the Binary Iota-Like Toxins, Infection and Immunity, vol.72, issue.5, pp.3066-3068, 2004. ,
DOI : 10.1128/IAI.72.5.3066-3068.2004
C2 toxin across membranes of acidified endosomes into the cytosol of mammalian cells, Cellular Microbiology, vol.54, issue.5, pp.780-795, 2009. ,
DOI : 10.1111/j.1365-2958.1997.tb02669.x
ABSTRACT, Infection and Immunity, vol.79, issue.10, pp.3913-3921, 2011. ,
DOI : 10.1128/IAI.05372-11
FK506-binding protein 51 interacts with Clostridium botulinum C2 toxin and FK506 inhibits membrane translocation of the toxin in mammalian cells, Cellular Microbiology, vol.104, issue.8, pp.1193-1205, 2012. ,
DOI : 10.1073/pnas.0707413104
URL : https://hal.archives-ouvertes.fr/pasteur-01762818
2724 | DOI:10.1038/s41598-017-02882-y 32, pp.1-22, 2016. ,
A novel Hsp70 inhibitor prevents cell intoxication with the actin ADP-ribosylating Clostridium perfringens iota toxin, Scientific Reports, vol.69, issue.1, p.20301, 2016. ,
DOI : 10.1128/IAI.69.5.2980-2987.2001
URL : https://hal.archives-ouvertes.fr/pasteur-01783777
Importing Mitochondrial Proteins: Machineries and Mechanisms, Cell, vol.138, issue.4, pp.628-644, 2009. ,
DOI : 10.1016/j.cell.2009.08.005
How Hsp70 Molecular Machines Interact with Their Substrates to Mediate Diverse Physiological Functions, Journal of Molecular Biology, vol.427, issue.7, pp.1575-1588, 2015. ,
DOI : 10.1016/j.jmb.2015.02.004
The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1823, issue.3, pp.624-635, 2012. ,
DOI : 10.1016/j.bbamcr.2011.09.003
Functional analysis of the hsp90-associated human peptidyl prolyl Cis/Trans isomerases FKBP51, FKBP52 and cyp40 1 1Edited by R. Huber, Journal of Molecular Biology, vol.308, issue.4, pp.795-806, 2001. ,
DOI : 10.1006/jmbi.2001.4595
Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones, Endocrine Reviews, vol.18, issue.3, pp.306-360, 1997. ,
DOI : 10.1210/er.18.3.306
, Journal of Medicinal Chemistry, vol.52, issue.6, pp.1510-1513, 2009.
DOI : 10.1021/jm801627a
Host Cell Chaperones Hsp70/Hsp90 and Peptidyl-Prolyl Cis/Trans Isomerases Are Required for the Membrane Translocation of Bacterial ADP-Ribosylating Toxins, Curr. Top. Microbiol. Immunol, vol.12, pp.10-1007, 2016. ,
DOI : 10.1111/j.1462-5822.2010.01480.x
Role of N-Terminal His6-Tags in Binding and Efficient Translocation of Polypeptides into Cells Using Anthrax Protective Antigen (PA), PLoS ONE, vol.7, issue.10, p.46964, 2012. ,
DOI : 10.1371/journal.pone.0046964.t001
Fused polycationic peptide mediates delivery of diphtheria toxin A chain to the cytosol in the presence of anthrax protective antigen., Proc. Natl. Acad. Sci. USA 93, pp.8437-8442, 1996. ,
DOI : 10.1073/pnas.93.16.8437
A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins, Nature Structural & Molecular Biology, vol.4, issue.11, pp.1273-1280, 2013. ,
DOI : 10.1074/jbc.M109.064691
Tyrosine glycosylation of Rho by Yersinia toxin impairs blastomere cell behaviour in zebrafish embryos, Nature Communications, vol.68, issue.1, p.7807, 2015. ,
DOI : 10.1107/S090744491200251X
Photorhabdus luminescens Toxins ADP-Ribosylate Actin and RhoA to Force Actin Clustering, Science, vol.366, issue.3, pp.1139-1142, 2010. ,
DOI : 10.1016/j.jmb.2006.11.100
???Miniguts??? from plucked human hair meet Crohn???s disease, Zeitschrift f??r Gastroenterologie, vol.54, issue.08, pp.748-759, 2016. ,
DOI : 10.1055/s-0042-105520
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche, Nature, vol.21, issue.7244, pp.262-265, 2009. ,
DOI : 10.1038/nature07935
Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro, Nature, vol.282, issue.7332, pp.105-109, 2011. ,
DOI : 10.1126/science.282.5391.1145
The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex, The Journal of Cell Biology, vol.265, issue.2, pp.1139-1150, 2003. ,
DOI : 10.1021/bi981436i
Role of CypA and Hsp90 in membrane translocation mediated by anthrax protective antigen, Cellular Microbiology, vol.12, issue.3, pp.359-373, 2011. ,
DOI : 10.1111/j.1462-5822.2010.01480.x
Insights into the molecular mechanism of allostery in Hsp70s, Frontiers in Molecular Biosciences, vol.112, issue.26, p.58, 2015. ,
DOI : 10.1073/pnas.1506692112
Co- and Post-translocation Roles for HSP90 in Cholera Intoxication, Journal of Biological Chemistry, vol.357, issue.48, pp.33644-33654, 2014. ,
DOI : 10.1371/journal.pone.0075801
Mechanism of Diphtheria Toxin Catalytic Domain Delivery to the Eukaryotic Cell Cytosol and the Cellular Factors that Directly Participate in the Process, Toxins, vol.13, issue.3, pp.294-308, 2011. ,
DOI : 10.1111/j.1462-5822.2010.01539.x
Hsp90 Is Required for Transfer of the Cholera Toxin A1 Subunit from the Endoplasmic Reticulum to the Cytosol, Journal of Biological Chemistry, vol.264, issue.41, pp.31261-31267, 2010. ,
DOI : 10.1038/sj.emboj.7601307
???ADP-ribosyltransferases, Cellular Microbiology, vol.12, issue.4, pp.490-503, 2014. ,
DOI : 10.1111/j.1462-5822.2010.01480.x
Hsp90 is involved in the entry of clostridial neurotoxins into the cytosol of nerve terminals, Cell. Microbiol, p.12647, 2016. ,
Direct observation of individual endogenous protein complexes in situ by proximity ligation, Nature Methods, vol.42, issue.12, pp.995-1000, 2006. ,
DOI : 10.1177/42.8.8027531
The mechanism of Hsp70 chaperones: (entropic) pulling the models together, Trends in Biochemical Sciences, vol.32, issue.8, pp.372-380, 2007. ,
DOI : 10.1016/j.tibs.2007.06.008
Modelling human development and disease in pluripotent stem-cell-derived gastric organoids, Nature, vol.12, issue.7531, pp.400-404, 2014. ,
DOI : 10.1038/nbt.2450
Spatial integration of E-cadherin adhesion, signalling and the epithelial cytoskeleton, Current Opinion in Cell Biology, vol.42, pp.138-145, 2016. ,
DOI : 10.1016/j.ceb.2016.07.006
Persistence and Toxin Production by Clostridium difficile within Human Intestinal Organoids Result in Disruption of Epithelial Paracellular Barrier Function, Infection and Immunity, vol.273, issue.1, pp.138-145, 2015. ,
DOI : 10.2174/092986711794839179
C2 Toxin by Site-directed Mutagenesis, Journal of Biological Chemistry, vol.269, issue.45, pp.29506-29511, 1998. ,
DOI : 10.1073/pnas.85.20.7521
Selective and specific internalization of clostridial C3 ADP-ribosyltransferases into macrophages and monocytes, Cellular Microbiology, vol.154, issue.2, pp.233-247, 2010. ,
DOI : 10.4049/jimmunol.169.5.2330
Clostridial Glucosylating Toxins Enter Cells via Clathrin-Mediated Endocytosis, PLoS ONE, vol.284, issue.8, p.10673, 2010. ,
DOI : 10.1371/journal.pone.0010673.g005
A syringe-like injection mechanism in Photorhabdus luminescens toxins, Nature, vol.25, issue.7442, pp.520-523, 2013. ,
DOI : 10.1002/jcc.20084
Analysis of Molecular Chaperone Activities Using In Vitro and In Vivo Approaches, Methods Mol. Biol. Clifton NJ, vol.99, pp.393-419, 2000. ,
DOI : 10.1385/1-59259-054-3:393
???-Dimethylcarboxamidomethyl)cycloheximide Has Potent Neuroprotective and Neurotrophic Properties in Brain Ischemia, Journal of Biological Chemistry, vol.211, issue.21, pp.14961-14970, 2006. ,
DOI : 10.1038/2251022a0
, Biochemistry, vol.37, issue.45, pp.15737-15746, 1998.
DOI : 10.1021/bi981436i
9-Donor-Substituted Acridizinium Salts:?? Versatile Environment-Sensitive Fluorophores for the Detection of Biomacromolecules, Journal of the American Chemical Society, vol.129, issue.5, pp.1254-1267, 2007. ,
DOI : 10.1021/ja0668872
Functional Analysis of Hsp70 Inhibitors, PLoS ONE, vol.271, issue.11, p.78443, 2013. ,
DOI : 10.1371/journal.pone.0078443.s005
URL : http://doi.org/10.1371/journal.pone.0078443