Gene flow contributes to diversification of the major fungal pathogen $Candida\ albicans$ - Archive ouverte HAL Access content directly
Journal Articles Nature Communications Year : 2018

Gene flow contributes to diversification of the major fungal pathogen $Candida\ albicans$

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Christophe Battail
Jong Hee Shin
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  • PersonId : 1007633

Abstract

Elucidating population structure and levels of genetic diversity and recombination is necessary to understand the evolution and adaptation of species. $Candida\ albicans$ is the second most frequent agent of human fungal infections worldwide, causing high-mortality rates. Here we present the genomic sequences of 182 C. $albicans$ isolates collected worldwide, including commensal isolates, as well as ones responsible for superficial and invasive infections, constituting the largest dataset to date for this major fungal pathogen. Although, C. $albicans$ shows a predominantly clonal population structure, we find evidence of gene flow between previously known and newly identified genetic clusters, supporting the occurrence of (para)sexuality in nature. A highly clonal lineage, which experimentally shows reduced fitness, has undergone pseudogenization in genes required for virulence and morphogenesis, which may explain its niche restriction. $Candida\ albicans$ thus takes advantage of both clonality and gene flow to diversify.
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pasteur-01815656 , version 1 (14-06-2018)

Licence

Attribution - CC BY 4.0

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Jeanne Ropars, Corinne Maufrais, Dorothée Diogo, Marina Marcet-Houben, Aurélie Perin, et al.. Gene flow contributes to diversification of the major fungal pathogen $Candida\ albicans$. Nature Communications, 2018, 9 (1), pp.2253. ⟨10.1038/s41467-018-04787-4⟩. ⟨pasteur-01815656⟩
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