S. Aerts, X. J. Quan, A. Claeys, M. Sanchez, P. Tate et al., Robust Target Gene Discovery through Transcriptome Perturbations and Genome-Wide Enhancer Predictions in Drosophila Uncovers a Regulatory Basis for Sensory Specification, PLoS Biology, vol.102, issue.7, p.1000435, 2010.
DOI : 10.1371/journal.pbio.1000435.s024

URL : http://doi.org/10.1371/journal.pbio.1000435

M. A. Akbar, S. Ray, and H. Krämer, The SM Protein Car/Vps33A Regulates SNARE-mediated Trafficking to Lysosomes and Lysosome-related Organelles, Molecular Biology of the Cell, vol.117, issue.6, pp.1705-1714, 2009.
DOI : 10.1242/jcs.00139

URL : http://www.molbiolcell.org/content/20/6/1705.full.pdf

D. Berdnik and J. A. Knoblich, Drosophila Aurora-A Is Required for Centrosome Maturation and Actin-Dependent Asymmetric Protein Localization during Mitosis, Current Biology, vol.12, issue.8, pp.640-647, 2002.
DOI : 10.1016/S0960-9822(02)00766-2

URL : https://doi.org/10.1016/s0960-9822(02)00766-2

D. Berdnik, T. Török, M. González-gaitán, and J. A. Knoblich, The Endocytic Protein ??-Adaptin Is Required for Numb-Mediated Asymmetric Cell Division in Drosophila, Developmental Cell, vol.3, issue.2, pp.221-231, 2002.
DOI : 10.1016/S1534-5807(02)00215-0

URL : https://doi.org/10.1016/s1534-5807(02)00215-0

C. Collinet, M. Stöter, C. R. Bradshaw, N. Samusik, J. C. Rink et al., Systems survey of endocytosis by multiparametric image analysis, Nature, vol.9, issue.7286, pp.243-249, 2010.
DOI : 10.1038/nature08779

M. Cotton, N. Benhra, and R. L. Borgne, Numb Inhibits the Recycling of Sanpodo in Drosophila Sensory Organ Precursor, Current Biology, vol.23, issue.7, pp.581-587, 2013.
DOI : 10.1016/j.cub.2013.02.020

URL : https://hal.archives-ouvertes.fr/inserm-00826290

F. Coumailleau, M. Fürthauer, J. A. Knoblich, and M. González-gaitán, Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division, Nature, vol.20, issue.7241, pp.1051-1055, 2009.
DOI : 10.1038/nature07854

L. Couturier and F. Schweisguth, Antibody Uptake Assay and In Vivo Imaging to Study Intracellular Trafficking of Notch and Delta in Drosophila, Methods Mol. Biol, vol.1187, pp.79-86978, 2014.
DOI : 10.1007/978-1-4939-1139-4_6

L. Couturier, N. Vodovar, and F. Schweisguth, Endocytosis by Numb breaks Notch symmetry at??cytokinesis, Nature Cell Biology, vol.122, issue.2, pp.131-139, 2012.
DOI : 10.1038/35050558

L. Couturier, K. Mazouni, and F. Schweisguth, Numb Localizes at Endosomes and Controls the Endosomal Sorting of Notch after Asymmetric Division in Drosophila, Current Biology, vol.23, issue.7, pp.588-593955, 2013.
DOI : 10.1016/j.cub.2013.03.002

L. Borgne, R. , and F. Schweisguth, Unequal Segregation of Neuralized Biases Notch Activation during Asymmetric Cell Division, Developmental Cell, vol.5, issue.1, pp.139-148, 2003.
DOI : 10.1016/S1534-5807(03)00187-4

L. Borgne, R. , A. Bardin, and F. Schweisguth, The roles of receptor and ligand endocytosis in regulating Notch signaling, Development, vol.132, issue.8, pp.1751-1762, 2005.
DOI : 10.1242/dev.01789

V. K. Lund, Y. Delotto, and R. Delotto, Endocytosis is required for Toll signaling and shaping of the Dorsal/NF-??B morphogen gradient during Drosophila embryogenesis, Proc. Natl. Acad. Sci. USA, pp.18028-18033, 2010.
DOI : 10.1242/dev.010934

URL : http://www.pnas.org/content/107/42/18028.full.pdf

P. J. Macdonald, Y. Chen, and J. D. Mueller, Chromophore maturation and fluorescence fluctuation spectroscopy of fluorescent proteins in a cell-free expression system, Analytical Biochemistry, vol.421, issue.1, pp.291-298, 2012.
DOI : 10.1016/j.ab.2011.10.040

URL : http://europepmc.org/articles/pmc3367886?pdf=render

E. Marois, A. Mahmoud, and S. Eaton, The endocytic pathway and formation of the Wingless morphogen gradient, Development, vol.133, issue.2, pp.307-317, 2006.
DOI : 10.1242/dev.02197

URL : http://dev.biologists.org/content/develop/133/2/307.full.pdf

M. A. Mcgill, S. E. Dho, G. Weinmaster, and C. J. Mcglade, Numb Regulates Post-endocytic Trafficking and Degradation of Notch1, Journal of Biological Chemistry, vol.146, issue.39, pp.26427-26438, 2009.
DOI : 10.1074/jbc.M802072200

C. J. Merrifield, D. Perrais, and D. Zenisek, Coupling between Clathrin-Coated-Pit Invagination, Cortactin Recruitment, and Membrane Scission Observed in Live Cells, Cell, vol.121, issue.4, pp.593-606, 2005.
DOI : 10.1016/j.cell.2005.03.015

URL : https://doi.org/10.1016/j.cell.2005.03.015

E. M. Merzlyak, J. Goedhart, D. Shcherbo, M. E. Bulina, A. S. Shcheglov et al., Bright monomeric red fluorescent protein with an extended fluorescence lifetime, Nature Methods, vol.24, issue.7, pp.555-557, 2007.
DOI : 10.1038/nmeth1062

A. Mukherjee, A. Veraksa, A. Bauer, C. Rosse, J. Camonis et al., Regulation of Notch signalling by non-visual ??-arrestin, Nature Cell Biology, vol.152, issue.12, pp.1191-1201, 2005.
DOI : 10.1126/science.285.5434.1737

J. Ni, R. Zhou, B. Czech, L. Liu, L. Holderbaum et al., A genome-scale shRNA resource for transgenic RNAi in Drosophila, Nature Methods, vol.121, issue.5, pp.405-407, 2011.
DOI : 10.1016/j.molcel.2009.09.028

URL : http://europepmc.org/articles/pmc3489273?pdf=render

U. Nienhaus, T. Aegerter-wilmsen, and C. M. Aegerter, In-Vivo Imaging of the Drosophila Wing Imaginal Disc over Time: Novel Insights on Growth and Boundary Formation, PLoS ONE, vol.7, issue.10, p.47594, 2012.
DOI : 10.1371/journal.pone.0047594.g008

L. Nilsson, B. Conradt, A. F. Ruaud, C. C. Chen, J. Hatzold et al., Caenorhabditis elegans num-1 Negatively Regulates Endocytic Recycling, Genetics, vol.179, issue.1, pp.375-387, 2008.
DOI : 10.1534/genetics.108.087247

URL : http://www.genetics.org/content/genetics/179/1/375.full.pdf

T. Nishimura and K. Kaibuchi, Numb Controls Integrin Endocytosis for Directional Cell Migration with aPKC and PAR-3, Developmental Cell, vol.13, issue.1, pp.15-28, 2007.
DOI : 10.1016/j.devcel.2007.05.003

URL : https://doi.org/10.1016/j.devcel.2007.05.003

O. , K. M. , and J. B. Skeath, Numb inhibits membrane localization of Sanpodo, a four-pass transmembrane protein, to promote asymmetric divisions in Drosophila, Dev. Cell, vol.5, issue.03, pp.231-243, 2003.

S. Ohkuma and B. Poole, Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents., Proc. Natl. Acad. Sci. USA, pp.3327-3331, 1978.
DOI : 10.1073/pnas.75.7.3327

E. Pavlopoulos, C. Pitsouli, K. M. Klueg, M. A. Muskavitch, N. K. Moschonas et al., neuralized Encodes a Peripheral Membrane Protein Involved in Delta Signaling and Endocytosis, Developmental Cell, vol.1, issue.6, pp.807-816, 2001.
DOI : 10.1016/S1534-5807(01)00093-4

URL : https://doi.org/10.1016/s1534-5807(01)00093-4

S. Polo and P. P. Di-fiore, Endocytosis Conducts the Cell Signaling Orchestra, Cell, vol.124, issue.5, pp.897-900, 2006.
DOI : 10.1016/j.cell.2006.02.025

URL : https://doi.org/10.1016/j.cell.2006.02.025

M. S. Rhyu, L. Y. Jan, and Y. N. , Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells, Cell, vol.76, issue.3, pp.477-491, 1994.
DOI : 10.1016/0092-8674(94)90112-0

E. Santolini, C. Puri, A. E. Salcini, M. C. Gagliani, P. G. Pelicci et al., Numb Is an Endocytic Protein, The Journal of Cell Biology, vol.124, issue.6, pp.1345-1352, 2000.
DOI : 10.1073/pnas.97.12.6844

URL : http://jcb.rupress.org/content/jcb/151/6/1345.full.pdf

K. Sato, T. Watanabe, S. Wang, M. Kakeno, K. Matsuzawa et al., Numb controls E-cadherin endocytosis through p120 catenin with aPKC, Molecular Biology of the Cell, vol.117, issue.17, pp.3103-3119, 2011.
DOI : 10.1242/jcs.00893

URL : http://www.molbiolcell.org/content/22/17/3103.full.pdf

E. S. Seto, H. J. Bellen, and T. E. Lloyd, When cell biology meets development: endocytic regulation of signaling pathways, Genes & Development, vol.16, issue.11, pp.1314-1336, 2002.
DOI : 10.1101/gad.989602

URL : http://genesdev.cshlp.org/content/16/11/1314.full.pdf

F. De-chaumont, S. Dallongeville, N. Chenouard, N. Hervé, S. Pop et al., Icy: an open bioimage informatics platform for extended reproducible research, Nature Methods, vol.9, issue.7, pp.690-696, 2012.
DOI : 10.1038/nmeth.1924

G. P. Doherty, K. Bailey, and P. J. Lewis, Stage-specific fluorescence intensity of GFP and mCherry during sporulation in bacillus subtilis, BMC Res. Notes, vol.3, p.303, 2010.

E. Donà, J. D. Barry, G. Valentin, C. Quirin, A. Khmelinskii et al., Directional tissue migration through a self-generated chemokine gradient, Nature, vol.25, issue.7475, pp.285-289, 2013.
DOI : 10.1093/bioinformatics/btp184

P. Fabrowski, A. S. Necakov, S. Mumbauer, E. Loeser, A. Reversi et al., Tubular endocytosis drives remodelling of the apical surface during epithelial morphogenesis in Drosophila, Nature Communications, vol.20, issue.1, p.2244, 2013.
DOI : 10.1006/meth.2000.0953

M. Gho and F. Schweisguth, Frizzled signalling controls orientation of asymmetric sense organ precursor cell divisions in Drosophila, Nature, vol.393, issue.6681, pp.178-181, 1998.
DOI : 10.1038/30265

M. Gho, Y. Bellaïche, and F. Schweisguth, Revisiting the Drosophila microchaete lineage: a novel intrinsically asymmetric cell division generates a glial cell, Development, vol.126, pp.3573-3584, 1999.

V. Hartenstein and J. W. Posakony, Development of adult sensilla on the wing and notum of Drosophila melanogaster, Development, vol.107, pp.389-405, 1989.

V. Hartenstein and J. W. Posakony, A dual function of the Notch gene in Drosophila sensillum development, Developmental Biology, vol.142, issue.1, pp.13-300012, 1990.
DOI : 10.1016/0012-1606(90)90147-B

E. Hebisch, J. Knebel, J. Landsberg, E. Frey, and M. Leisner, High Variation of Fluorescence Protein Maturation Times in Closely Related Escherichia coli Strains, PLoS ONE, vol.7, issue.10, p.75991, 2013.
DOI : 10.1371/journal.pone.0075991.s012

URL : https://doi.org/10.1371/journal.pone.0075991

P. D. Hsu, E. S. Lander, and F. Zhang, Development and Applications of CRISPR-Cas9 for Genome Engineering, Cell, vol.157, issue.6, pp.1262-1278, 2014.
DOI : 10.1016/j.cell.2014.05.010

J. Huang, W. Zhou, W. Dong, A. M. Watson, and Y. Hong, From the Cover: Directed, efficient, and versatile modifications of the Drosophila genome by genomic engineering, Proc. Natl. Acad. Sci. USA, pp.8284-8289, 2009.

J. Huotari and A. Helenius, Endosome maturation, The EMBO Journal, vol.335, issue.17, pp.3481-3500, 2011.
DOI : 10.1016/j.bbrc.2005.07.070

URL : http://emboj.embopress.org/content/embojnl/30/17/3481.full.pdf

A. Hutterer and J. A. Knoblich, Numb and ??-Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs, EMBO reports, vol.5, issue.9, pp.836-842, 2005.
DOI : 10.1083/jcb.200211087

URL : http://embor.embopress.org/content/embor/6/9/836.full.pdf

R. Iizuka, M. Yamagishi-shirasaki, and T. Funatsu, Kinetic study of de novo chromophore maturation of fluorescent proteins, Analytical Biochemistry, vol.414, issue.2, pp.173-178, 2011.
DOI : 10.1016/j.ab.2011.03.036

R. Jaekel and T. Klein, The Drosophila Notch Inhibitor and Tumor Suppressor Gene lethal (2) giant discs Encodes a Conserved Regulator of Endosomal Trafficking, Developmental Cell, vol.11, issue.5, pp.655-669, 2006.
DOI : 10.1016/j.devcel.2006.09.019

URL : https://doi.org/10.1016/j.devcel.2006.09.019

V. Kandachar and F. Roegiers, Endocytosis and control of Notch signaling, Current Opinion in Cell Biology, vol.24, issue.4, pp.534-540, 2012.
DOI : 10.1016/j.ceb.2012.06.006

URL : http://europepmc.org/articles/pmc3425709?pdf=render

A. Khmelinskii, P. J. Keller, A. Bartosik, M. Meurer, J. D. Barry et al., Tandem fluorescent protein timers for in vivo analysis of protein dynamics, Nature Biotechnology, vol.36, issue.7, pp.708-714, 2012.
DOI : 10.1038/nbt1186

S. Kimura, T. Noda, and T. Yoshimori, Dissection of the Autophagosome Maturation Process by a Novel Reporter Protein, Tandem Fluorescent-Tagged LC3, Autophagy, vol.3, issue.5, pp.452-460, 2007.
DOI : 10.4161/auto.4451

URL : http://www.tandfonline.com/doi/pdf/10.4161/auto.4451?needAccess=true

M. Kneen, J. Farinas, Y. Li, and A. S. Verkman, Green Fluorescent Protein as a Noninvasive Intracellular pH Indicator, Biophysical Journal, vol.74, issue.3, pp.1591-1599, 1998.
DOI : 10.1016/S0006-3495(98)77870-1

URL : https://doi.org/10.1016/s0006-3495(98)77870-1

J. R. Krieger, P. Taylor, A. S. Gajadhar, A. Guha, M. F. Moran et al., Identification and Selected Reaction Monitoring (SRM) Quantification of Endocytosis Factors Associated with Numb, Molecular & Cellular Proteomics, vol.121, issue.2, pp.499-514, 2013.
DOI : 10.1074/jbc.M503912200

URL : http://www.mcponline.org/content/12/2/499.full.pdf

E. C. Lai, G. A. Deblandre, C. Kintner, and G. M. Rubin, Drosophila Neuralized Is a Ubiquitin Ligase that Promotes the Internalization and Degradation of Delta, Developmental Cell, vol.1, issue.6, pp.783-794, 2001.
DOI : 10.1016/S1534-5807(01)00092-2

URL : https://doi.org/10.1016/s1534-5807(01)00092-2

J. Langevin, R. Le-borgne, F. Rosenfeld, M. Gho, F. Schweisguth et al., Lethal giant larvae controls the localization of notchsignaling regulators numb, neuralized, and Sanpodo in Drosophila 363, 2005.

, Live imaging of endosomal sorting ? Couturier et al

N. C. Shaner, P. A. Steinbach, and R. Y. Tsien, A guide to choosing fluorescent proteins, Nature Methods, vol.102, issue.12, pp.905-909, 2005.
DOI : 10.1099/00221287-147-5-1383

D. M. Shcherbakova and V. V. Verkhusha, Near-infrared fluorescent proteins for multicolor in vivo imaging, Nature Methods, vol.132, issue.8, pp.751-754, 2013.
DOI : 10.1016/j.cell.2008.01.016

C. A. Smith, S. E. Dho, J. Donaldson, U. Tepass, and C. J. Mcglade, The Cell Fate Determinant Numb Interacts with EHD/Rme-1 Family Proteins and Has a Role in Endocytic Recycling, Molecular Biology of the Cell, vol.15, issue.8, pp.3698-3708, 2004.
DOI : 10.1016/S0960-9822(01)00149-X

Y. Song and B. Lu, Interaction of Notch Signaling Modulator Numb with ??-Adaptin Regulates Endocytosis of Notch Pathway Components and Cell Fate Determination of Neural Stem Cells, Journal of Biological Chemistry, vol.126, issue.21, pp.17716-17728, 2012.
DOI : 10.1016/S0092-8674(00)81923-6

F. V. Subach, G. H. Patterson, S. Manley, J. M. Gillette, J. Lippincott-schwartz et al., Photoactivatable mCherry for high-resolution two-color fluorescence microscopy, Nature Methods, vol.1, issue.2, pp.153-159, 2009.
DOI : 10.1007/s00340-007-2729-0

URL : http://europepmc.org/articles/pmc2901231?pdf=render

M. J. Taylor, D. Perrais, and C. J. Merrifield, A high precision survey of the molecular dynamics of mammalian clathrin-mediated endocytosis, PLoS Biol, vol.9, 2011.

X. Tong, D. Zitserman, I. Serebriiskii, M. Andrake, R. Dunbrack et al., Numb Independently Antagonizes Sanpodo Membrane Targeting and Notch Signaling in Drosophila Sensory Organ Precursor Cells, Molecular Biology of the Cell, vol.19, issue.5, pp.802-810, 2010.
DOI : 10.1093/emboj/19.7.1505

URL : http://www.molbiolcell.org/content/21/5/802.full.pdf

T. Troost, S. Jaeckel, N. Ohlenhard, and T. Klein, The tumour suppressor Lethal (2) giant discs is required for the function of the ESCRT-III component Shrub/CHMP4, Journal of Cell Science, vol.125, issue.3, pp.763-776, 2012.
DOI : 10.1242/jcs.097261

T. Uemura, S. Shepherd, L. Ackerman, L. Y. Jan, and Y. N. , numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos, Cell, vol.58, issue.2, pp.349-3600092, 1989.
DOI : 10.1016/0092-8674(89)90849-0

A. Upadhyay, V. Kandachar, D. Zitserman, X. Tong, and F. Roegiers, Sanpodo controls sensory organ precursor fate by directing Notch trafficking and binding ??-secretase, The Journal of Cell Biology, vol.51, issue.3, pp.439-448, 2013.
DOI : 10.1083/jcb.201209023.dv

URL : http://europepmc.org/articles/pmc3639393?pdf=render

T. Vaccari and D. Bilder, The Drosophila Tumor Suppressor vps25 Prevents Nonautonomous Overproliferation by Regulating Notch Trafficking, Developmental Cell, vol.9, issue.5, pp.687-698, 2005.
DOI : 10.1016/j.devcel.2005.09.019

URL : https://doi.org/10.1016/j.devcel.2005.09.019

K. J. Venken, Y. He, R. A. Hoskins, and H. J. Bellen, P[acman]: A BAC Transgenic Platform for Targeted Insertion of Large DNA Fragments in D. melanogaster, Science, vol.314, issue.5806, pp.1747-1751, 2006.
DOI : 10.1126/science.1134426

V. V. Verkhusha, N. A. Akovbian, E. N. Efremenko, S. D. Varfolomeyev, and P. V. Vrzheshch, Kinetic analysis of maturation and denaturation of DsRed, a coral-derived red fluorescent protein, Biochemistry (Moscow), vol.66, issue.12, pp.1342-13511013325627378, 2001.
DOI : 10.1023/A:1013325627378

D. J. Yamashiro and F. R. Maxfield, Acidification of morphologically distinct endosomes in mutant and wild- type Chinese hamster ovary cells, The Journal of Cell Biology, vol.105, issue.6, pp.2723-2733, 1987.
DOI : 10.1083/jcb.105.6.2723

URL : http://jcb.rupress.org/content/jcb/105/6/2723.full.pdf

Y. Yan, N. Denef, and T. Schüpbach, The Vacuolar Proton Pump, V-ATPase, Is Required for Notch Signaling and Endosomal Trafficking in Drosophila, Developmental Cell, vol.17, issue.3, pp.387-402, 2009.
DOI : 10.1016/j.devcel.2009.07.001

URL : https://doi.org/10.1016/j.devcel.2009.07.001

J. Yousefian, T. Troost, F. Grawe, T. Sasamura, M. Fortini et al., Dmon1 controls recruitment of Rab7 to maturing endosomes in Drosophila, Journal of Cell Science, vol.126, issue.7, pp.1583-1594, 2013.
DOI : 10.1242/jcs.114934

URL : http://jcs.biologists.org/content/joces/126/7/1583.full.pdf

C. Zeng, S. Younger-shepherd, L. Y. Jan, and Y. N. , Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ??lineage, Genes & Development, vol.12, issue.8, pp.1086-1091, 1998.
DOI : 10.1101/gad.12.8.1086

URL : http://genesdev.cshlp.org/content/12/8/1086.full.pdf