 |
Journal articles
Control of Neural Daughter Cell Proliferation by Multi-level Notch/Su(H)/E(spl)-HLH Signaling
Abstract : The Notch pathway controls proliferation during development and in adulthood, and is frequently affected in many disorders. However, the genetic sensitivity and multi-layered tran-scriptional properties of the Notch pathway has made its molecular decoding challenging. Here, we address the complexity of Notch signaling with respect to proliferation, using the developing Drosophila CNS as model. We find that a Notch/Su(H)/E(spl)-HLH cascade specifically controls daughter, but not progenitor proliferation. Additionally, we find that different E(spl)-HLH genes are required in different neuroblast lineages. The Notch/Su(H)/E(spl)-HLH cascade alters daughter proliferation by regulating four key cell cycle factors: Cyclin E, String/Cdc25, E2f and Dacapo (mammalian p21 CIP1
Cited literature [82 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-01812648
Contributor : Doriane Thouvenot <>
Submitted on : Monday, June 11, 2018 - 4:25:04 PM
Last modification on : Friday, November 27, 2020 - 3:06:02 PM
Long-term archiving on: : Wednesday, September 12, 2018 - 6:20:15 PM
Contributor : Doriane Thouvenot <>
Submitted on : Monday, June 11, 2018 - 4:25:04 PM
Last modification on : Friday, November 27, 2020 - 3:06:02 PM
Long-term archiving on: : Wednesday, September 12, 2018 - 6:20:15 PM
File
journal.pgen.1005984.PDF
Publication funded by an institution
Licence
Distributed under a Creative Commons Attribution 4.0 International License