S. Amatsu, Y. Sugawara, T. Matsumura, K. Kitadokoro, and Y. Fujinaga, Whole Hemagglutinin Reveals a Huge Triskelion-shaped Molecular Complex, Journal of Biological Chemistry, vol.10, issue.49, pp.35617-35625, 2013.
DOI : 10.1016/j.jmb.2011.07.066

F. Antonucci, C. Rossi, L. Gianfranceschi, O. Rossetto, and M. Caleo, Long-Distance Retrograde Effects of Botulinum Neurotoxin A, Journal of Neuroscience, vol.28, issue.14, pp.3689-3696, 2008.
DOI : 10.1523/JNEUROSCI.0375-08.2008

H. Arimitsu, K. Inoue, Y. Sakaguchi, J. Lee, Y. Fujinaga et al., Purification of Fully Activated Clostridium botulinum Serotype B Toxin for Treatment of Patients with Dystonia, Infection and Immunity, vol.71, issue.3, pp.1599-1603, 2003.
DOI : 10.1128/IAI.71.3.1599-1603.2003

H. Arimitsu, Y. Sakaguchi, J. C. Lee, S. Ochi, K. Tsukamoto et al., Molecular properties of each subcomponent in Clostridium botulinum type B haemagglutinin complex, Microbial Pathogenesis, vol.45, issue.2, pp.142-149, 2008.
DOI : 10.1016/j.micpath.2008.04.007

C. Connan and M. R. Popoff,

S. S. Arnon, Creation and Development of the Public Service Orphan Drug Human Botulism Immune Globulin, PEDIATRICS, vol.119, issue.4, pp.785-789, 2007.
DOI : 10.1542/peds.2006-0646

D. A. Benefield, S. K. Dessain, N. Shine, M. D. Ohi, and D. B. Lacy, Molecular assembly of botulinum neurotoxin progenitor complexes, Proc. Natl. Acad. Sci. USA, pp.5630-5635, 2013.
DOI : 10.1002/jcc.20084

K. P. Bhatia, A. Munchau, P. D. Thompson, M. Houser, V. S. Chauhan et al., Generalised muscular weakness after botulinum toxin injections for dystonia: a report of three cases, Journal of Neurology, Neurosurgery & Psychiatry, vol.67, issue.1, pp.90-93, 1999.
DOI : 10.1136/jnnp.67.1.90

H. Bigalke and E. Habermann, Blockade by tetanus and botulinum A toxin of postganglionic cholinergic nerve endings in the myenteric plexus, Naunyn-Schmiedeberg's Archives of Pharmacology, vol.156, issue.3, pp.255-263, 1980.
DOI : 10.1111/j.1476-5381.1970.tb12903.x

J. D. Black and J. O. Dolly, Selective location of acceptors for botulinum neurotoxin a in the central and peripheral nervous systems, Neuroscience, vol.23, issue.2, pp.767-779, 1987.
DOI : 10.1016/0306-4522(87)90094-7

S. Bohnert and G. Schiavo, Tetanus Toxin Is Transported in a Novel Neuronal Compartment Characterized by a Specialized pH Regulation, Journal of Biological Chemistry, vol.49, issue.51, pp.42336-42344, 2005.
DOI : 10.1074/jbc.M504890200

P. F. Bonventre, Absorption of Botulinal Toxin from the Gastrointestinal Tract, Clinical Infectious Diseases, vol.1, issue.4, pp.663-667, 1979.
DOI : 10.1093/clinids/1.4.663

M. A. Breidenbach and A. T. Brunger, Biochemistry, vol.44, issue.20, pp.7450-7457, 2005.
DOI : 10.1021/bi050262j

S. H. Brookes, Classes of enteric nerve cells in the guinea-pig small intestine, The Anatomical Record, vol.71, issue.1, pp.58-70, 2001.
DOI : 10.1113/jphysiol.1989.sp017722

R. Chadda, M. T. Howes, S. J. Plowman, J. F. Hancock, R. G. Parton et al., Cholesterol-Sensitive Cdc42 Activation Regulates Actin Polymerization for Endocytosis via the GEEC Pathway, Traffic, vol.107, issue.6, pp.702-717, 2007.
DOI : 10.1111/j.1600-0854.2007.00565.x

L. W. Cheng, I. Henderson, and T. D. , Comparison of oral toxicological properties of botulinum neurotoxin serotypes A and B, Toxicon, vol.58, issue.1, pp.62-67, 2011.
DOI : 10.1016/j.toxicon.2011.05.003

J. A. Coffield, N. M. Bakry, A. B. Maksymowych, and L. L. Simpson, Characterization of a vertebrate neuromuscular junction that demonstrates selective resistance to botulinum toxin, J. Pharmacol. Exp. Ther, vol.289, issue.3, pp.1509-1516, 1999.

C. Connan, C. Varela-chavez, C. Mazuet, J. Molgo, G. M. Haustant et al., Translocation and dissemination to target neurons of botulinum neurotoxin type B in the mouse intestinal wall, Cellular Microbiology, vol.20, issue.320, pp.282-301, 2016.
DOI : 10.3748/wjg.v20.i32.11273
URL : https://hal.archives-ouvertes.fr/pasteur-01780625

A. Couesnon, C. Colasante, J. Molgo, and M. R. Popoff, Differential entry of Botulinum Neurotoxin A into neuronal and intestinal cells: an ultrastructural approach, The Botulinum J., vol.1, issue.4, pp.375-392, 2010.
DOI : 10.1504/TBJ.2010.039113
URL : https://hal.archives-ouvertes.fr/pasteur-01758348

A. Couesnon, J. Molgo, C. Connan, and M. R. Popoff, Preferential Entry of Botulinum Neurotoxin A Hc Domain through Intestinal Crypt Cells and Targeting to Cholinergic Neurons of the Mouse Intestine, PLoS Pathogens, vol.156, issue.3, p.1002583, 2012.
DOI : 10.1371/journal.ppat.1002583.s003
URL : https://hal.archives-ouvertes.fr/pasteur-00681779

A. Couesnon, Y. Pereira, and M. R. Popoff, Receptor-mediated transcytosis of botulinum neurotoxin A through intestinal cell monolayers, Cellular Microbiology, vol.263, issue.0, pp.375-387, 2008.
DOI : 10.1074/jbc.M205258200

A. Couesnon, T. Shimizu, and M. R. Popoff, Differential entry of botulinum neurotoxin A into neuronal and intestinal cells, Cellular Microbiology, vol.277, issue.2, pp.289-308, 2009.
DOI : 10.1016/j.bbamcr.2005.11.014
URL : https://hal.archives-ouvertes.fr/pasteur-01758348

S. S. Dineen, M. Bradshaw, and E. A. Johnson, Neurotoxin Gene Clusters in Clostridium botulinum Type A Strains: Sequence Comparison and Evolutionary Implications, Current Microbiology, vol.46, issue.5, pp.342-352, 2003.
DOI : 10.1007/s00284-002-3851-1

M. Elias, F. Al-saleem, D. M. Ancharski, A. Singh, Z. Nasser et al., Evidence That Botulinum Toxin Receptors on Epithelial Cells and Neuronal Cells Are Not Identical: Implications for Development of a Non-Neurotropic Vaccine, Journal of Pharmacology and Experimental Therapeutics, vol.336, issue.3, pp.605-612, 2011.
DOI : 10.1124/jpet.110.175018

P. Emsley, C. Fotinou, I. Black, N. F. Fairweather, I. G. Charles et al., Fragment of Tetanus Toxin with Carbohydrate Subunit Complexes Provide Insight into Ganglioside Binding, Journal of Biological Chemistry, vol.63, issue.12, pp.8889-8894, 2000.
DOI : 10.1006/jmbi.1999.2945
URL : http://www.jbc.org/content/275/12/8889.full.pdf

C. Fotinou, P. Emsley, I. Black, H. Ando, H. Ishida et al., The Crystal Structure of Tetanus Toxin Hc Fragment Complexed with a Synthetic GT1b Analogue Suggests Cross-linking between Ganglioside Receptors and the Toxin, Journal of Biological Chemistry, vol.63, issue.34, pp.3274-3281, 2001.
DOI : 10.1016/S0014-5793(01)02273-6

Z. Fu, S. Chen, M. R. Baldwin, G. E. Boldt, A. Crawford et al., Biochemistry, vol.45, issue.29, pp.8903-8911, 2006.
DOI : 10.1021/bi060786z

Y. Fujinaga, K. Inoue, T. Nomura, J. Sasaki, J. C. Marvaud et al., Identification and characterization of functional subunits of Clostridium botulinum type A progenitor toxin involved in binding to intestinal microvilli and erythrocytes, FEBS Lett, vol.467, pp.2-3179, 2000.

Y. Fujinaga, K. Inoue, S. Watanabe, K. Yokota, Y. Hirai et al., The haemagglutinin of Clostridium botulinum type C progenitor toxin plays an essential role in binding of toxin to the epithelial cells of guinea pig small intestine, leading to the efficient absorption of the toxin, Microbiology, vol.143, issue.12, pp.3841-3847, 1997.
DOI : 10.1099/00221287-143-12-3841

Y. Fujinaga, K. Inoue, S. Watarai, G. Sakaguchi, H. Arimitsu et al., Molecular characterization of binding subcomponents of Clostridium botulinum type C progenitor toxin for intestinal epithelial cells and erythrocytes', Microbiol, pp.1529-1538, 2004.

Y. Fujinaga, T. Matsumura, Y. Jin, Y. Takegahara, and Y. Sugawara, A novel function of botulinum toxin-associated proteins: HA proteins disrupt intestinal epithelial barrier to increase toxin absorption, Toxicon, vol.54, issue.5, pp.583-586, 2009.
DOI : 10.1016/j.toxicon.2008.11.014

Y. Fujinaga, Y. Sugawara, and T. Matsumura, Uptake of Botulinum Neurotoxin in the Intestine, Curr. Top. Microbiol. Immunol, vol.364, pp.45-59, 2013.
DOI : 10.1007/978-3-662-45790-0_3

J. B. Furness, Types of neurons in the enteric nervous system, Journal of the Autonomic Nervous System, vol.81, issue.1-3, pp.1-387, 2000.
DOI : 10.1016/S0165-1838(00)00127-2

J. B. Furness, The enteric nervous system and neurogastroenterology, Nature Reviews Gastroenterology & Hepatology, vol.394, issue.5, pp.286-294, 2012.
DOI : 10.1113/jphysiol.1987.sp016860

J. B. Furness, B. P. Callaghan, L. R. Rivera, and H. J. Cho, The Enteric Nervous System and Gastrointestinal Innervation: Integrated Local and Central Control, Adv. Exp. Med. Biol, vol.817, pp.39-71, 2014.
DOI : 10.1007/978-1-4939-0897-4_3

J. B. Furness, C. A. Jones, K. Nurgali, and N. Clerc, Intrinsic primary afferent neurons and nerve circuits within the intestine, Progress in Neurobiology, vol.72, issue.2, pp.143-164, 2004.
DOI : 10.1016/j.pneurobio.2003.12.004

C. G. Garner, A. Straube, T. N. Witt, T. Gasser, and W. H. Oertel, Time course of distant effects of local injections of botulinum toxin, Movement Disorders, vol.23, issue.1, pp.33-37, 1993.
DOI : 10.1212/WNL.38.11.1780

N. C. Gauthier, P. Monzo, V. Kaddai, A. Doye, V. Ricci et al., VacA Cytotoxin: A Probe for a Clathrin-independent and Cdc42-dependent Pinocytic Pathway Routed to Late Endosomes, Molecular Biology of the Cell, vol.16, issue.10, pp.4852-4866, 2005.
DOI : 10.1038/35052055
URL : https://hal.archives-ouvertes.fr/inserm-00000100

R. K. Goyal and I. Hirano, The Enteric Nervous System, New England Journal of Medicine, vol.334, issue.17, pp.1106-1115, 1996.
DOI : 10.1056/NEJM199604253341707

J. Gruenberg, The endocytic pathway: a mosaic of domains, Nature Reviews Molecular Cell Biology, vol.17, issue.10, pp.721-730, 2001.
DOI : 10.1093/emboj/17.17.4930

D. Grundy and M. Schermann, Enteric nervous system, Current Opinion in Gastroenterology, vol.22, issue.2, pp.102-110, 2006.
DOI : 10.1097/01.mog.0000208459.46395.16

C. Connan and M. R. Popoff,

S. Gu, S. Rumpel, J. Zhou, J. Strotmeier, H. Bigalke et al., Botulinum Neurotoxin Is Shielded by NTNHA in an Interlocked Complex, Science, vol.332, issue.1, pp.977-981, 2012.
DOI : 10.1016/j.ab.2004.04.031

A. M. Harrington, J. M. Hutson, and B. R. Southwell, Cholinergic neurotransmission and muscarinic receptors in the enteric nervous system, Progress in Histochemistry and Cytochemistry, vol.44, issue.4, pp.173-202, 2010.
DOI : 10.1016/j.proghi.2009.10.001

K. Hasegawa, T. Watanabe, T. Suzuki, A. Yamano, T. Oikawa et al., Serotype D Toxin Complex with Three Extended Arms, Journal of Biological Chemistry, vol.6, issue.34, pp.24777-24783, 2007.
DOI : 10.1038/78005
URL : http://www.jbc.org/content/282/34/24777.full.pdf

L. Hernandes, P. Gama, and E. P. Alvares, Ileal VIP submucous neurons: confocal study of the area enlargement induced by myenteric denervation in weanling rats, Regulatory Peptides, vol.117, issue.1, pp.69-72, 2004.
DOI : 10.1016/j.regpep.2003.10.006

K. K. Hill and T. J. Smith, Genetic Diversity Within Clostridium botulinum Serotypes, Botulinum Neurotoxin Gene Clusters and Toxin Subtypes, Curr. Top. Microbiol. Immunol, vol.364, pp.1-20, 2013.
DOI : 10.1007/978-3-662-45790-0_1

H. B. Hines, F. Lebeda, M. Hale, and E. E. Brueggemann, Characterization of Botulinum Progenitor Toxins by Mass Spectrometry, Applied and Environmental Microbiology, vol.71, issue.8, pp.4478-4486, 2005.
DOI : 10.1128/AEM.71.8.4478-4486.2005
URL : http://aem.asm.org/content/71/8/4478.full.pdf

H. Igarashi, N. Fujimori, T. Ito, T. Nakamura, T. Oono et al., Vasoactive Intestinal Peptide (VIP) and VIP Receptors-Elucidation of Structure and Function for Therapeutic Applications, International Journal of Clinical Medicine, vol.02, issue.04, pp.500-508, 2011.
DOI : 10.4236/ijcm.2011.24084
URL : http://www.scirp.org/journal/PaperDownload.aspx?paperID=7567

K. Inui, H. Ito, K. Miyata, T. Matsuo, R. Horiuchi et al., Involvement of Sialic Acid in Transport of Serotype C1 Botulinum Toxins through Rat Intestinal Epithelial Cells, Journal of Veterinary Medical Science, vol.72, issue.9, pp.1251-1255, 2010.
DOI : 10.1292/jvms.10-0090

K. Inui, Y. Sagane, K. Miyata, S. Miyashita, T. Suzuki et al., Toxic and nontoxic components of botulinum neurotoxin complex are evolved from a common ancestral zinc protein, Biochemical and Biophysical Research Communications, vol.419, issue.3, pp.500-504, 2012.
DOI : 10.1016/j.bbrc.2012.02.045

H. Ito, Y. Sagane, K. Miyata, K. Inui, T. Matsuo et al., HA-33 facilitates transport of the serotype D botulinum toxin across a rat intestinal epithelial cell monolayer, FEMS Immunology & Medical Microbiology, vol.17, issue.3, pp.323-331, 2011.
DOI : 10.1111/j.1742-4658.2005.04688.x

A. N. James, J. P. Ryan, and H. P. Parkman, Inhibitory effects of botulinum toxin on pyloric and antral smooth muscle, American Journal of Physiology-Gastrointestinal and Liver Physiology, vol.285, issue.2, pp.291-297, 2003.
DOI : 10.1067/mge.2003.98
URL : http://ajpgi.physiology.org/content/ajpgi/285/2/G291.full.pdf

M. A. Jepson and M. A. Clark, Studying M cells and their role in infection, Trends in Microbiology, vol.6, issue.9, pp.359-365, 1998.
DOI : 10.1016/S0966-842X(98)01337-7

Y. Jin, Y. Takegahara, Y. Sugawara, T. Matsumura, and Y. Fujinaga, Disruption of the epithelial barrier by botulinum haemagglutinin (HA) proteins - differences in cell tropism and the mechanism of action between HA proteins of types A or B, and HA proteins of type C, Microbiology, vol.51, issue.10, pp.35-45, 2009.
DOI : 10.1016/S0006-291X(05)80328-6

J. E. Keller, F. Cai, and E. A. Neale, Uptake of Botulinum Neurotoxin into Cultured Neurons, Biochemistry, vol.43, issue.2, pp.526-532, 2004.
DOI : 10.1021/bi0356698

M. Kitamura, S. Sakaguchi, and G. Sakaguchi, Significance of 12S toxin of Clostridium botulinum type E', J. Bacteriol, vol.98, issue.3, pp.1173-1178, 1969.

H. Kobayashi, K. Fujisawa, Y. Saito, M. Kamijo, S. Oshima et al., A botulism case of a 12-year-old girl caused by intestinal colonization of Clostridium botulinum type Ab', Jpn, J. Infect. Dis, vol.56, issue.2, pp.73-74, 2003.

S. Kojima, H. Eguchi, T. Ookawara, N. Fujiwara, J. Yasuda et al., Clostridium botulinum type A progenitor toxin binds to Intestine-407 cells via N -acetyllactosamine moiety, Biochemical and Biophysical Research Communications, vol.331, issue.2, pp.571-576, 2005.
DOI : 10.1016/j.bbrc.2005.04.007

H. Kouguchi, T. Watanabe, Y. Sagane, H. Sunagawa, and T. Ohyama, Type D Progenitor Toxin, Journal of Biological Chemistry, vol.28, issue.4, pp.2650-2656, 2002.
DOI : 10.1038/78005

D. Kumaran, S. Eswaramoorthy, W. Furey, J. Navaza, M. Sax et al., Domain Organization in Clostridium botulinum Neurotoxin Type E Is Unique: Its Implication in Faster Translocation, Journal of Molecular Biology, vol.386, issue.1, pp.233-245, 2009.
DOI : 10.1016/j.jmb.2008.12.027

D. B. Lacy and R. C. Stevens, Sequence homology and structural analysis of the clostridial neurotoxins, Journal of Molecular Biology, vol.291, issue.5, pp.1091-1104, 1999.
DOI : 10.1006/jmbi.1999.2945

D. B. Lacy, W. Tepp, A. C. Cohen, B. R. Das-gupta, and R. C. Stevens, Crystal structure of botulinum neurotoxin type A and implications for toxicity, Nature Structural Biology, vol.11, issue.10, pp.898-902, 1998.
DOI : 10.1002/prot.340110407

T. I. Lam, L. H. Stanker, K. Lee, R. Jin, and L. W. Cheng, Translocation of botulinum neurotoxin serotype A and associated proteins across the intestinal epithelia, Cellular Microbiology, vol.6, issue.8, pp.1133-1143, 2015.
DOI : 10.3390/toxins6020624
URL : https://onlinelibrary.wiley.com/doi/pdf/10.1111/cmi.12424

C. Lamanna, The Most Poisonous Poison: What do we know about the toxin of botulism? What are the problems to be solved?, Science, vol.130, issue.3378, pp.763-772, 1959.
DOI : 10.1126/science.130.3378.763

K. Lee, X. Zhong, S. Gu, A. M. Kruel, M. B. Dorner et al., Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex, Science, vol.64, issue.5, pp.1405-1410, 2014.
DOI : 10.1006/bbrc.2002.6689
URL : http://europepmc.org/articles/pmc4164303?pdf=render

M. A. Lietzow, E. T. Gielow, D. Le, J. Zhang, and M. F. Verhagen, Subunit Stoichiometry of the Clostridium botulinum Type A Neurotoxin Complex Determined Using Denaturing Capillary Electrophoresis, The Protein Journal, vol.346, issue.7-8, pp.7-8420, 2008.
DOI : 10.1002/(SICI)1097-4598(1997)6+<129::AID-MUS9>3.0.CO;2-B

G. Lin, W. H. Tepp, C. L. Pier, M. J. Jacobson, and E. A. Johnson, Expression of the Clostridium botulinum A2 Neurotoxin Gene Cluster Proteins and Characterization of the A2 Complex, Applied and Environmental Microbiology, vol.76, issue.1, pp.40-47, 2010.
DOI : 10.1128/AEM.01882-09

P. A. Low, Autonomic neuropathies, Current Opinion in Neurology, vol.15, issue.5, pp.605-609, 2002.
DOI : 10.1097/00019052-200210000-00011

I. Mackenzie, G. Burnstock, and J. O. Dolly, The effects of purified botulinum neurotoxin type A on cholinergic, adrenergic and non-adrenergic, atropine-resistant autonomic neuromuscular transmission, Neuroscience, vol.7, issue.4, pp.997-1006, 1982.
DOI : 10.1016/0306-4522(82)90056-2

A. B. Maksymowych and L. I. Simpson, Structural Features of the Botulinum Neurotoxin Molecule That Govern Binding and Transcytosis across Polarized Human Intestinal Epithelial Cells, Journal of Pharmacology and Experimental Therapeutics, vol.310, issue.2, pp.633-641, 2004.
DOI : 10.1124/jpet.104.066845
URL : http://jpet.aspetjournals.org/content/jpet/310/2/633.full.pdf

A. B. Maksymowych and L. L. Simpson, Binding and Transcytosis of Botulinum Neurotoxin by Polarized Human Colon Carcinoma Cells, Journal of Biological Chemistry, vol.65, issue.34, pp.21950-21957, 1998.
DOI : 10.1016/0378-1119(95)00152-V
URL : http://www.jbc.org/content/273/34/21950.full.pdf

T. Matsui, S. Gu, K. H. Lam, L. G. Carter, A. Rummel et al., Structural Basis of the pH-Dependent Assembly of a Botulinum Neurotoxin Complex, Journal of Molecular Biology, vol.426, issue.22, pp.496-499, 2014.
DOI : 10.1016/j.jmb.2014.09.009

T. Matsumura, Y. Jin, Y. Kabumoto, Y. Takegahara, K. Oguma et al., The HA proteins of botulinum toxin disrupt intestinal epithelial intercellular junctions to increase toxin absorption, Cellular Microbiology, vol.248, issue.0, pp.355-364, 2008.
DOI : 10.1046/j.1462-5822.2000.00025.x
URL : http://onlinelibrary.wiley.com/doi/10.1111/j.1462-5822.2007.01048.x/pdf

T. Matsumura, Y. Sugawara, M. Yutani, S. Amatsu, H. Yagita et al., Botulinum toxin A complex exploits intestinal M cells to enter the host and exert neurotoxicity, Nature Communications, vol.10, issue.1, p.6255, 2015.
DOI : 10.1074/jbc.M410599200
URL : http://www.nature.com/articles/ncomms7255.pdf

G. M. Mawe and J. M. Hoffman, Serotonin signalling in the gut???functions, dysfunctions and therapeutic targets, Nature Reviews Gastroenterology & Hepatology, vol.20, issue.8, pp.473-486, 2013.
DOI : 10.1053/j.gastro.2005.08.005
URL : http://europepmc.org/articles/pmc4048923?pdf=render

A. J. May and B. C. Whaler, The absorption of Clostridium botulinum type Atoxin from the alimentary canal, Br. J. Exp. Path, vol.39, issue.3, pp.307-316, 1958.

C. Connan and M. R. Popoff,

S. Mayor and R. E. Pagano, Pathways of clathrin-independent endocytosis, Nature Reviews Molecular Cell Biology, vol.264, issue.8, pp.603-612, 2007.
DOI : 10.1177/44.8.8756764

P. G. Mclean, R. A. Borman, and K. Lee, 5-HT in the enteric nervous system: gut function and neuropharmacology, Trends in Neurosciences, vol.30, issue.1, pp.9-13, 2007.
DOI : 10.1016/j.tins.2006.11.002

J. L. Middlebrook and D. R. Franz, Botulinum toxins The Surgeon General, Medical Aspects of Chemical and Biological Warfare, 1997.

M. Montal, Botulinum Neurotoxin: A Marvel of Protein Design, Annual Review of Biochemistry, vol.79, issue.1, pp.591-617, 2010.
DOI : 10.1146/annurev.biochem.051908.125345

B. Moreno-lopez, R. R. De-la-cruz, A. M. Pastor, and J. M. Delgado-garcia, Effects of botulinum neurotoxin type A on abducens motoneurons in the cat: alterations of the discharge pattern, Neuroscience, vol.81, issue.2, pp.437-455, 1997.
DOI : 10.1016/S0306-4522(97)00199-1

S. Mutoh, H. Kouguchi, Y. Sagane, T. Suzuki, K. Hasegawa et al., Biochemistry, vol.42, issue.37, pp.10991-10997, 2003.
DOI : 10.1021/bi034996c

A. Nishikawa, N. Uotsu, H. Arimitsu, J. C. Lee, Y. Miura et al., The receptor and transporter for internalization of Clostridium botulinum type C progenitor toxin into HT-29 cells, Biochemical and Biophysical Research Communications, vol.319, issue.2, pp.327-333, 2004.
DOI : 10.1016/j.bbrc.2004.04.183

K. Niwa, T. Yoneyama, H. Ito, M. Taira, T. Chikai et al., Sialic acid-dependent binding and transcytosis of serotype D botulinum neurotoxin and toxin complex in rat intestinal epithelial cells, Veterinary Microbiology, vol.141, issue.3-4, pp.3-4312, 2010.
DOI : 10.1016/j.vetmic.2009.09.008

K. Oguma, K. Inoue, Y. Fujinaga, K. Yokota, T. Watanabe et al., Structure and function of Clostridium botulinum progenitor toxin, J. Toxicol, vol.18, pp.17-34, 1999.

I. Ohishi and G. Sakaguchi, Oral toxicities of Clostridium botulinum type C and D toxins of different molecular sizes, Infect. Immun, vol.28, issue.2, pp.303-309, 1980.

I. Ohishi, S. Sugii, and G. Sakaguchi, Oral toxicites of Clostridium botulinum toxins in response to molecular size, Infect. Immun, vol.16, issue.1, pp.107-109, 1977.

P. J. Pasricha, W. J. Ravich, and A. N. Kalloo, Effects of intrasphincteric botulinum toxin on the lower esophageal sphincter in piglets, Gastroenterology, vol.105, issue.4, pp.1045-1049, 1993.
DOI : 10.1016/0016-5085(93)90947-B

K. A. Petro, M. A. Dyer, B. C. Yowler, and C. L. Schengrund, Disruption of lipid rafts enhances activity of botulinum neurotoxin serotype A, Toxicon, vol.48, issue.8, pp.1035-1045, 2006.
DOI : 10.1016/j.toxicon.2006.08.011

M. R. Popoff and J. C. Marvaud, Structural and genomic features of clostridial neurotoxins, The Comprehensive Sourcebook of Bacterial Protein Toxins, 1999.

B. Poulain, M. R. Popoff, and J. Molgo, How do the Botulinum Neurotoxins block neurotransmitter release: from botulism to the molecular mechanism of action, The Botulinum J., vol.1, issue.1, pp.14-87, 2008.
DOI : 10.1504/TBJ.2008.018951
URL : https://hal.archives-ouvertes.fr/hal-00303601

S. A. Predescu, D. N. Predescu, B. K. Timblin, R. V. Stan, and A. B. Malik, Intersectin Regulates Fission and Internalization of Caveolae in Endothelial Cells, Molecular Biology of the Cell, vol.14, issue.12, pp.4997-5010, 2003.
DOI : 10.1016/B978-0-12-164717-9.50028-3
URL : http://www.molbiolcell.org/content/14/12/4997.full.pdf

C. P. Quinn and N. P. Minton, Clostridial Neurotoxins, 2001.
DOI : 10.1002/3527600108.ch7

L. Restani, F. Antonucci, L. Gianfranceschi, C. Rossi, O. Rossetto et al., Evidence for Anterograde Transport and Transcytosis of Botulinum Neurotoxin A (BoNT/A), Journal of Neuroscience, vol.31, issue.44, pp.15650-15659, 2011.
DOI : 10.1523/JNEUROSCI.2618-11.2011

L. Restani, F. Giribaldi, M. Manich, K. Bercsenyi, G. Menendez et al., Botulinum Neurotoxins A and E Undergo Retrograde Axonal Transport in Primary Motor Neurons, PLoS Pathogens, vol.5, issue.8, p.1003087, 2012.
DOI : 10.1371/journal.ppat.1003087.s010
URL : https://doi.org/10.1371/journal.ppat.1003087

A. Roux, K. Uyhazi, A. Frost, D. Camilli, and P. , GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission, Nature, vol.93, issue.7092, pp.528-531, 2006.
DOI : 10.1073/pnas.93.21.11443

A. Rummel, Double Receptor Anchorage of Botulinum Neurotoxins Accounts for their Exquisite Neurospecificity, Curr. Top. Microbiol. Immunol, vol.364, issue.10, pp.61-90978, 1007.
DOI : 10.1007/978-3-662-45790-0_4

A. Rummel, S. Mahrhold, H. Bigalke, and T. Binz, The HCC-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction, Molecular Microbiology, vol.277, issue.3, pp.631-643, 2004.
DOI : 10.1042/bj2360845

S. Sabharanjak, P. Sharma, R. G. Parton, and S. Mayor, GPI-Anchored Proteins Are Delivered to Recycling Endosomes via a Distinct cdc42-Regulated, Clathrin-Independent Pinocytic Pathway, Developmental Cell, vol.2, issue.4, pp.411-423, 2002.
DOI : 10.1016/S1534-5807(02)00145-4
URL : https://doi.org/10.1016/s1534-5807(02)00145-4

J. Sand, I. Nordback, P. Arvola, I. Porsti, A. Kalloo et al., Effects of botulinum toxin A on the sphincter of Oddi: an in vivo and in vitro study, Gut, vol.42, issue.4, pp.507-510, 1998.
DOI : 10.1136/gut.42.4.507

S. K. Sharma, M. A. Ramzan, and B. R. Singh, Separation of the components of type A botulinum neurotoxin complex by electrophoresis, Toxicon, vol.41, issue.3, pp.321-331, 2003.
DOI : 10.1016/S0041-0101(02)00309-4

F. Simpson, N. K. Hussain, B. Qualman, R. B. Kelly, B. K. Kay et al., SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation, Nature Cell Biol, vol.1, issue.2, pp.119-124, 1999.

L. Simpson, The life history of a botulinum toxin molecule, Toxicon, vol.68, pp.40-59, 2013.
DOI : 10.1016/j.toxicon.2013.02.014

L. L. Simpson, J. A. Coffield, and N. Bakry, Inhibition of vacuolar adenosine triphosphatase antagonizes the effects of clostridial neurotoxins but not phospholipase A2 neurotoxins, J. Pharmacol. Exp. Ther, vol.269, issue.1, pp.256-262, 1994.

B. R. Singh, T. Wang, R. Kukreja, and S. Cai, The Botulinum Neurotoxin Complex and the Role of Ancillary Proteins, Molecular Aspects of Botulinum Neurotoxin, 2014.
DOI : 10.1007/978-1-4614-9454-6_4

L. A. Smith, Bacterial protein toxins as biological weapons, 2006.
DOI : 10.1016/B978-012088445-2/50067-6

P. Stenmark, J. Dupuy, A. Imamura, M. Kiso, and R. C. Stevens, Crystal Structure of Botulinum Neurotoxin Type A in Complex with the Cell Surface Co-Receptor GT1b???Insight into the Toxin???Neuron Interaction, PLoS Pathogens, vol.10, issue.8, p.1000129, 2008.
DOI : 10.1371/journal.ppat.1000129.s002

Y. Sugawara and Y. Fujinaga, The botulinum toxin complex meets E-cadherin on the way to its destination, Cell Adhesion & Migration, vol.24, issue.1, pp.34-36, 2011.
DOI : 10.2307/1589803
URL : http://www.tandfonline.com/doi/pdf/10.4161/cam.5.1.13574?needAccess=true

Y. Sugawara, M. Iwamori, T. Matsumura, M. Yutani, S. Amatsu et al., type C hemagglutinin affects the morphology and viability of cultured mammalian cells via binding to the ganglioside GM3, FEBS Journal, vol.24, issue.17, pp.3334-3347, 2015.
DOI : 10.1016/j.ceb.2012.06.009

Y. Sugawara, T. Matsumura, Y. Takegahara, Y. Jin, Y. Tsukasaki et al., Botulinum hemagglutinin disrupts the intercellular epithelial barrier by directly binding E-cadherin, The Journal of Cell Biology, vol.16, issue.4, pp.691-700, 2010.
DOI : 10.1083/jcb.200910119.dv
URL : http://europepmc.org/articles/pmc2872904?pdf=render

Y. Sugawara, M. Yutani, S. Amatsu, T. Matsumura, and Y. Fujinaga, Functional Dissection of the Clostridium botulinum Type B Hemagglutinin Complex: Identification of the Carbohydrate and E-Cadherin Binding Sites, PLoS ONE, vol.344, issue.10, pp.111170-2014, 2014.
DOI : 10.1371/journal.pone.0111170.g005

S. Sugii, I. Ohishi, and G. Sakaguchi, Correlation between oral toxicity and in vitro stability of Clostridium botulinum type A and B toxins of different molecular sizes, Infect. Immun, vol.16, issue.3, pp.910-914, 1977.

C. Connan and M. R. Popoff,

S. Sugii, I. Ohishi, and G. Sakaguchi, Intestinal absorption of botulinum toxins of different molecular sizes in rats, Infect. Immun, vol.17, issue.3, pp.491-496, 1977.

S. Swaminathan and S. Eswaramoorthy, Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B', Nature Structural Biology, vol.7, issue.8, pp.693-699, 2000.
DOI : 10.1038/78005

C. O. Tacket and M. A. Rogawski, Botulinum Neurotoxin and Tetanus Toxin, 1989.

K. Takei, Y. Yoshida, and H. Yamada, Regulatory Mechanisms of Dynamin-Dependent Endocytosis, Journal of Biochemistry, vol.137, issue.3, pp.243-247, 2005.
DOI : 10.1093/jb/mvi052

T. C. Umland, L. M. Wingert, S. Swaminathan, W. F. Furey, J. J. Schmidt et al., Structure of the receptor binding fragment HC of tetanus neurotoxin, Natural Structural Biology, vol.22, issue.10, pp.788-792, 1997.
DOI : 10.1107/S0021889891007240

C. Verderio, C. Grumelli, L. Raiteri, S. Coco, S. Paluzzi et al., Traffic of Botulinum Toxins A and E in Excitatory and Inhibitory Neurons, Traffic, vol.113, issue.Suppl. 8, pp.142-153, 2007.
DOI : 10.1016/S1388-2457(02)00103-7

L. Vereecke, R. Beyaert, and G. Van-loo, Enterocyte death and intestinal barrier maintenance in homeostasis and disease, Trends in Molecular Medicine, vol.17, issue.10, pp.584-593, 2011.
DOI : 10.1016/j.molmed.2011.05.011

G. Yao, K. Lee, S. Gu, K. H. Lam, and R. Jin, Botulinum Neurotoxin A Complex Recognizes Host Carbohydrates through Its Hemagglutinin Component, Toxins, vol.1770, issue.2, pp.624-635, 2014.
DOI : 10.1002/0471140864.ps1210s64

K. Zhang, M. W. Hornef, and A. Dupont, The intestinal epithelium as guardian of gut barrier integrity, Cellular Microbiology, vol.265, issue.11, pp.1561-1569, 2015.
DOI : 10.1111/imr.12293