Skip to Main content Skip to Navigation
Journal articles

Attack of the nervous system by Clostridium perfringens Epsilon toxin: From disease to mode of action on neural cells

Abstract : Epsilon toxin (ET), produced by Clostridium perfringens types B and D, ranks among the four most potent poisonous substances known so far. ET-intoxication is responsible for enterotoxaemia in animals, mainly sheep and goats. This disease comprises several manifestations indicating the attack of the nervous system. This review aims to summarize the effects of ET on central nervous system. ET binds to endothelial cells of brain capillary vessels before passing through the blood-brain barrier. Therefore, it induces perivascular oedema and accumulates into brain. ET binding to different brain structures and to different component in the brain indicates regional susceptibility to the toxin. Histological examination has revealed nerve tissue and cellular lesions, which may be directly or indirectly caused by ET. The naturally occurring disease caused by ET-intoxication can be reproduced experimentally in rodents. In mice and rats, ET recognizes receptor at the surface of different neural cell types, including certain neurons (e.g. the granule cells in cerebellum) as well as oligodendrocytes, which are the glial cells responsible for the axons myelination. Moreover, ET induces release of glutamate and other transmitters, leading to firing of neural network. The precise mode of action of ET on neural cells remains to be determined.
Document type :
Journal articles
Complete list of metadatas

Cited literature [123 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-01793122
Contributor : Floran Bidault <>
Submitted on : Wednesday, May 16, 2018 - 11:16:03 AM
Last modification on : Wednesday, March 18, 2020 - 9:48:53 AM
Long-term archiving on: : Monday, September 24, 2018 - 7:51:37 PM

File

1-s2.0-S0041010113001335-main....
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Laetitia Wioland, Jean-Luc Dupont, Jean-Louis Bossu, Michel Popoff, Bernard Poulain. Attack of the nervous system by Clostridium perfringens Epsilon toxin: From disease to mode of action on neural cells. Toxicon, Elsevier, 2013, 75, pp.122 - 135. ⟨10.1016/j.toxicon.2013.04.003⟩. ⟨pasteur-01793122⟩

Share

Metrics

Record views

316

Files downloads

435