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Journal articles
The Aerolysin-Like Toxin Family of Cytolytic, Pore-Forming Toxins
Abstract : Pore-forming toxins (PFTs) represent the largest known group of bacterial protein toxins to date. Membrane insertion and subsequent pore-formation occurs after initial binding to cell-surface receptor and oligomerization. Aerolysin, a toxin produced by the Gram-negative bacterium Aeromonas hydrophila and related species, belongs to the PFT group and shares a common mechanism of action involving β-barrel structures resulting from the assembly of β-hairpins from individual toxin monomers into a heptamer. Aerolysin is also the name given to structurally and mechanistically related toxins called the aerolysin-like toxin family. A universal characteristic of this toxin family involves the diverse life forms that synthesize these proteins throughout Nature. Examples include: 1) epsilon-toxin and septicum-alpha-toxin produced by anaerobic, Gram-positive Clostridium species; 2) enterolobin by the Brazilian tree Enterolobium contortisiliquum; 3) a mushroom toxin Laetiporus sulphureus lectin (LSL); 4) mosquitocidal toxins (Mtxs) from the Gram-positive bacteria Bacillus sphaericus and parasporine-2 from Bacillus thuringiensis; and 6) hydralysins from the tiny aquatic animal Chlorohydra viridis. The following review provides an overview of the different members within the aerolysin-like toxin family.
Cited literature [96 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-01788617
Contributor : Floran Bidault <>
Submitted on : Wednesday, May 9, 2018 - 11:38:26 AM
Last modification on : Monday, January 13, 2020 - 5:08:05 PM
Long-term archiving on: : Tuesday, September 25, 2018 - 12:00:55 AM
Contributor : Floran Bidault <>
Submitted on : Wednesday, May 9, 2018 - 11:38:26 AM
Last modification on : Monday, January 13, 2020 - 5:08:05 PM
Long-term archiving on: : Tuesday, September 25, 2018 - 12:00:55 AM
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TOTNJ-3-53.pdf
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