O. Rossetto, M. Pirazzini, and C. Montecucco, Botulinum neurotoxins: genetic, structural and mechanistic insights, Nature Reviews Microbiology, vol.344, issue.8, pp.535-549, 2014.
DOI : 10.1126/science.1253823

L. Simpson, Annual Review of Pharmacology and Toxicology, vol.44, issue.1, pp.167-193, 2004.
DOI : 10.1146/annurev.pharmtox.44.101802.121554

J. Sobel, Botulism, Clinical Infectious Diseases, vol.178, issue.1, pp.1167-1173, 2005.
DOI : 10.1086/515615

M. Popoff, C. Mazuet, and B. Poulain, Botulism and Tetanus, The Prokaryotes: Human Microbiology, pp.247-290, 2013.
DOI : 10.1007/978-3-642-30144-5_97

M. Lindström and H. Korkeala, Laboratory Diagnostics of Botulism, Clinical Microbiology Reviews, vol.19, issue.2, pp.298-314, 2006.
DOI : 10.1128/CMR.19.2.298-314.2006

N. Dover, J. Barash, K. Hill, G. Xie, and S. Arnon, Molecular Characterization of a Novel Botulinum Neurotoxin Type H Gene, The Journal of Infectious Diseases, vol.235, issue.2, pp.192-202, 2014.
DOI : 10.1111/j.1574-6968.2004.tb09561.x

URL : https://academic.oup.com/jid/article-pdf/209/2/192/13804460/jit450.pdf

K. Hill and T. Smith, Genetic Diversity Within Clostridium botulinum Serotypes, Botulinum Neurotoxin Gene Clusters and Toxin Subtypes, Curr Top Microbiol Immunol, vol.364, pp.1-20, 2013.
DOI : 10.1007/978-3-662-45790-0_1

C. Mazuet, L. King, P. Bouvet, C. Legeay, J. Sautereau et al., Le botulisme humain en France, BEH, vol.6, pp.2010-2012106, 2014.

C. Mazuet, E. Ezan, H. Volland, M. Popoff, and F. Becher, Toxin Detection in Patients' Sera by Mass Spectrometry during Two Outbreaks of Type A Botulism in France, Journal of Clinical Microbiology, vol.50, issue.12, pp.4091-4094, 2012.
DOI : 10.1128/JCM.02392-12

URL : https://hal.archives-ouvertes.fr/pasteur-01762967

T. Smith, J. Lou, I. Geren, C. Forsyth, R. Tsai et al., Sequence Variation within Botulinum Neurotoxin Serotypes Impacts Antibody Binding and Neutralization, Infection and Immunity, vol.73, issue.9, pp.5450-5457, 2005.
DOI : 10.1128/IAI.73.9.5450-5457.2005

URL : http://iai.asm.org/content/73/9/5450.full.pdf

E. Arndt, M. Jacobson, E. Abola, C. Forsyth, W. Tepp et al., A Structural Perspective of the Sequence Variability Within Botulinum Neurotoxin Subtypes A1-A4, Journal of Molecular Biology, vol.362, issue.4, pp.733-742, 2006.
DOI : 10.1016/j.jmb.2006.07.040

J. Henkel, M. Jacobson, W. Tepp, C. Pier, E. Johnson et al., Biochemistry, vol.48, issue.11, pp.2522-2528, 2009.
DOI : 10.1021/bi801686b

S. Ahmed, M. Byrne, M. Jensen, H. Hines, E. Brueggemann et al., Enzymatic autocatalysis of botulinum A neurotoxin light chain, Journal of Protein Chemistry, vol.20, issue.3, pp.221-231, 2001.
DOI : 10.1023/A:1010952025677

, Page 11 of 24 Analytical & Bioanalytical Chemistry Specificity Tryptic digest fragment peptide sequence Conserved a I24-K34 IPNAGQMQPVK Conserved a Q67-K84 QVPVSYYDSTYLSTDNEK Conserved a G114, K128 GIPFWGGSTIDTELK Conserved b N178-R187 NGYGSTQYIR Conserved a L232-R241 LYGIAINPNR Conserved b N418-K427, N414-K423 for BoNT/A3 NFTGLFEFYK

/. Bont, A. A1, and S. Sfghevlnltr,

/. Bont, A. A1, and V. Vnytiydgfnlr,

/. Bont, A. A2, and F. Fatdpavtlahelihaehr,

/. Bont and . Dvastlnk,

/. Bont, A. A2, and S. Siigttaslqymk,

/. Bont and . Mlteiytednfvnffk,

/. Bont, A. A2, and I. Inivpdenytik,

/. Bont and . Ganlstnfngqnteinsr,

/. Bont and . Ihegvwviper,

/. Bont and . Iystglgr,

/. Bont and . Mllsfivk,

/. Bont and . Vidtncinviepggsyr,

/. Bont and . Seelnlvitgpsadiiqfeck,

/. Bont and . Sfghdvfnltr,

/. Bont and . Tnayyemsglevsfeelr,

/. Bont and . Tfggndtnfidslwqk,

/. Bont and . Daydnlqniar,

/. Bont and . Tivgtttplqymk,

/. Bont and . Yflsedasgk,

/. Bont and . Gftelefvnpfk,

/. Bont and . Iystelgr,

/. Bont and . Tfgehdak,

/. Bont and . Inivpevnytiydgfnlr,

/. Bont and . Ntnlaanfngqnteinnmnfak,

/. Bont and . Diftnpeegdlnpppeak,

/. Bont and . Seelnlviigpsadiinfeck,

/. Bont and . Faidpavtlahelihaghr,

/. Bont and . Evasilnk,

/. Bont and . Mnivpevnytiydgfnlr,

/. Bont and . Dtvngvdiayik,

/. Bont and . Dtftnpk,

/. Bont and . Egdlnpppeak,

/. Bont and . Tfgghnak,

/. Bont and . Ntnlaanfngqnteinsr,