D. Lacy and R. Stevens, Sequence homology and structural analysis of the clostridial neurotoxins, Journal of Molecular Biology, vol.291, issue.5, pp.1091-104, 1999.
DOI : 10.1006/jmbi.1999.2945

S. Arnon, R. Schechter, T. Inglesby, D. Henderson, J. Bartlett et al., Botulinum Toxin as a Biological Weapon, JAMA, vol.285, issue.8, pp.1059-70, 2001.
DOI : 10.1001/jama.285.8.1059

D. Gill, Bacterial toxins: a table of lethal amounts, Microbiol Rev, vol.46, pp.86-94, 1982.

E. Schantz and E. Johnson, Properties and use of botulinum toxin and other microbial neurotoxins in medicine, Microbiol Rev, vol.56, pp.80-99, 1992.

C. Montecucco and G. Schiavo, Mechanism of action of tetanus and botulinum neurotoxins, Molecular Microbiology, vol.263, issue.1, pp.1-8, 1994.
DOI : 10.1111/j.1432-1033.1986.tb09412.x

URL : https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2958.1994.tb00396.x

J. Rusnak and L. Smith, Botulinum Neurotoxin Vaccines:?? Past history and recent developments, Human Vaccines, vol.5, issue.12, pp.794-805, 2009.
DOI : 10.4161/hv.9420

URL : http://www.tandfonline.com/doi/pdf/10.4161/hv.9420?needAccess=true

L. Smith, Botulism and vaccines for its prevention, Vaccine, vol.27, issue.4, pp.33-42, 2009.
DOI : 10.1016/j.vaccine.2009.08.059

R. Kaji, New and emerging indications of botulinum toxin therapy, Parkinsonism & Related Disorders, vol.17, issue.1, pp.25-32, 2011.
DOI : 10.1016/j.parkreldis.2011.06.017

D. Franz, L. Pitt, M. Clayton, M. Hanes, and K. Rose, Efficacy of Prophylactic and Therapeutic Administration of Antitoxin for Inhalation Botulism, In: Botulinum Tetanus Neurotoxins Biomed Asp, 1993.
DOI : 10.1007/978-1-4757-9542-4_52

S. Arnon, R. Schechter, S. Maslanka, N. Jewell, and C. Hatheway, Human Botulism Immune Globulin for the Treatment of Infant Botulism, New England Journal of Medicine, vol.354, issue.5, pp.462-71, 2006.
DOI : 10.1056/NEJMoa051926

R. Black and R. Gunn, Hypersensitivity reactions associated with botulinal antitoxin, The American Journal of Medicine, vol.69, issue.4, pp.567-70, 1980.
DOI : 10.1016/0002-9343(80)90469-6

C. Mayers, S. Veall, R. Bedford, and J. Holley, , and Fab Botulinum Antitoxins in Mice, Immunopharmacology and Immunotoxicology, vol.150, issue.3, pp.397-408, 2003.
DOI : 10.1093/infdis/150.3.407

P. Amersdorfer, C. Wong, T. Smith, S. Chen, S. Deshpande et al., Genetic and immunological comparison of anti-botulinum type A antibodies from immune and non-immune human phage libraries, Vaccine, vol.20, issue.11-12, pp.1640-1648, 2002.
DOI : 10.1016/S0264-410X(01)00482-0

Z. Ahmad, S. Yeap, A. Ali, W. Ho, and N. Alitheen, Hamid M: scFv antibody: principles and clinical application, Clin Dev Immunol, vol.2012, p.980250, 2012.
DOI : 10.1155/2012/980250

URL : http://doi.org/10.1155/2012/980250

S. Adekar, T. Takahashi, R. Jones, F. Saleem, D. Ancharski et al., Neutralization of Botulinum Neurotoxin by a Human Monoclonal Antibody Specific for the Catalytic Light Chain, PLoS ONE, vol.304, issue.8, p.3023, 2008.
DOI : 10.1371/journal.pone.0003023.t002

A. Avril, J. Froude, J. Mathieu, T. Pelat, and P. Thullier, Isolation of Antibodies From Non-Human Primates for Clinical Use, Current Drug Discovery Technologies, vol.11, issue.1, pp.20-27, 2014.
DOI : 10.2174/15701638113109990030

T. Pelat, A. Avril, S. Chahboun, J. Mathieu, and P. Thullier, Development of Anti-Toxins Antibodies for Biodefense, Journal of Bioterrorism & Biodefense, vol.2, p.1, 2011.
DOI : 10.4172/2157-2526.S2-005

E. Laffly, L. Danjou, F. Condemine, D. Vidal, E. Drouet et al., Selection of a Macaque Fab with Framework Regions Like Those in Humans, High Affinity, and Ability To Neutralize the Protective Antigen (PA) of Bacillus anthracis by Binding to the Segment of PA between Residues 686 and 694, Antimicrobial Agents and Chemotherapy, vol.49, issue.8, pp.3414-3434, 2005.
DOI : 10.1128/AAC.49.8.3414-3420.2005

T. Rülker, L. Voß, P. Thullier, O. Brien, L. Pelat et al., Isolation and Characterisation of a Human-Like Antibody Fragment (scFv) That Inactivates VEEV In Vitro and In Vivo, PLoS ONE, vol.384, issue.4, p.37242, 2012.
DOI : 10.1371/journal.pone.0037242.g005

T. Pelat, M. Hust, E. Laffly, F. Condemine, C. Bottex et al., High-Affinity, Human Antibody-Like Antibody Fragment (Single-Chain Variable Fragment) Neutralizing the Lethal Factor (LF) of Bacillus anthracis by Inhibiting Protective Antigen-LF Complex Formation, Antimicrobial Agents and Chemotherapy, vol.51, issue.8, pp.2758-64, 2007.
DOI : 10.1128/AAC.01528-06

URL : http://aac.asm.org/content/51/8/2758.full.pdf

T. Pelat, M. Hust, M. Hale, M. Lefranc, S. Dübel et al., Isolation of a human-like antibody fragment (scFv) that neutralizes ricin biological activity, BMC Biotechnology, vol.9, issue.1, p.60, 2009.
DOI : 10.1186/1472-6750-9-60

URL : https://hal.archives-ouvertes.fr/hal-00410069

S. Chahboun, M. Hust, Y. Liu, T. Pelat, S. Miethe et al., Isolation of a nanomolar scFv inhibiting the endopeptidase activity of botulinum toxin A, by single-round panning of an immune phage-displayed library of macaque origin, BMC Biotechnology, vol.11, issue.1, p.113, 2011.
DOI : 10.1186/1472-6750-11-113

S. Miethe, C. Rasetti-escargueil, Y. Liu, S. Chahboun, T. Pelat et al., Development of neutralizing scFv-Fc against botulinum neurotoxin A light chain from a macaque immune library, mAbs, vol.57, issue.2, pp.446-59, 2014.
DOI : 10.1038/2338

URL : http://www.tandfonline.com/doi/pdf/10.4161/mabs.27773?needAccess=true

M. Schütte, P. Thullier, T. Pelat, X. Wezler, P. Rosenstock et al., Identification of a Putative Crf Splice Variant and Generation of Recombinant Antibodies for the Specific Detection of Aspergillus fumigatus, PLoS ONE, vol.202, issue.8, p.6625, 2009.
DOI : 10.1371/journal.pone.0006625.t003

M. Hust, T. Meyer, B. Voedisch, T. Rülker, H. Thie et al., A human scFv antibody generation pipeline for proteome research, Journal of Biotechnology, vol.152, issue.4, pp.159-70, 2011.
DOI : 10.1016/j.jbiotec.2010.09.945

M. Kirsch, B. Hülseweh, C. Nacke, T. Rülker, T. Schirrmann et al., Development of human antibody fragments using antibody phage display for the detection and diagnosis of Venezuelan equine encephalitis virus (VEEV), BMC Biotechnology, vol.8, issue.1, p.66, 2008.
DOI : 10.1186/1472-6750-8-66

T. Pelat, H. Bedouelle, A. Rees, S. Crennell, M. Lefranc et al., Germline Humanization of a Non-human Primate Antibody that Neutralizes the Anthrax Toxin, by in Vitro and in Silico Engineering, Journal of Molecular Biology, vol.384, issue.5, pp.1400-1407, 2008.
DOI : 10.1016/j.jmb.2008.10.033

URL : https://hal.archives-ouvertes.fr/hal-00345933

P. Thullier, O. Huish, T. Pelat, and A. Martin, The Humanness of Macaque Antibody Sequences, Journal of Molecular Biology, vol.396, issue.5, pp.1439-50, 2010.
DOI : 10.1016/j.jmb.2009.12.041

URL : http://acrmwww.biochem.ucl.ac.uk/publications/freepdf/macaque_submit.pdf

S. Kalb, J. Lou, C. Garcia-rodriguez, I. Geren, T. Smith et al., Extraction and Inhibition of Enzymatic Activity of Botulinum Neurotoxins/A1, /A2, and /A3 by a Panel of Monoclonal Anti-BoNT/A Antibodies, PLoS ONE, vol.5, issue.10, p.5355, 2009.
DOI : 10.1371/journal.pone.0005355.t003

A. Nowakowski, C. Wang, D. Powers, P. Amersdorfer, T. Smith et al., Potent neutralization of botulinum neurotoxin by recombinant oligoclonal antibody, Proceedings of the National Academy of Sciences, vol.287, issue.5458, pp.11346-50, 2002.
DOI : 10.1126/science.287.5458.1664

URL : http://www.pnas.org/content/99/17/11346.full.pdf

L. Cheng, L. Stanker, T. Henderson-2nd, J. Lou, and J. Marks, Antibody Protection against Botulinum Neurotoxin Intoxication in Mice, Infection and Immunity, vol.77, issue.10, pp.4305-4318, 2009.
DOI : 10.1128/IAI.00405-09

URL : http://iai.asm.org/content/77/10/4305.full.pdf

J. Conway, L. Sherwood, M. Collazo, J. Garza, and A. Hayhurst, Llama Single Domain Antibodies Specific for the 7 Botulinum Neurotoxin Serotypes as Heptaplex Immunoreagents, PLoS ONE, vol.5, issue.1, p.8818, 2010.
DOI : 10.1371/journal.pone.0008818.s003

URL : http://doi.org/10.1371/journal.pone.0008818

B. Dolimbek, K. Aoki, L. Steward, J. Jankovic, and M. Atassi, Mapping of the regions on the heavy chain of botulinum neurotoxin A (BoNT/A) recognized by antibodies of cervical dystonia patients with immunoresistance to BoNT/A, Molecular Immunology, vol.44, issue.5, pp.1029-1070, 2007.
DOI : 10.1016/j.molimm.2006.03.011

K. Hill, T. Smith, C. Helma, L. Ticknor, B. Foley et al., Genetic Diversity among Botulinum Neurotoxin-Producing Clostridial Strains, Journal of Bacteriology, vol.189, issue.3, pp.818-850, 2007.
DOI : 10.1128/JB.01180-06

URL : http://jb.asm.org/content/189/3/818.full.pdf

A. Carter, C. Paul, D. Mason, S. Twine, M. Alston et al., Independent evolution of neurotoxin and flagellar genetic loci in proteolytic Clostridium botulinum, BMC Genomics, vol.10, issue.1, p.115, 2009.
DOI : 10.1186/1471-2164-10-115

URL : https://bmcgenomics.biomedcentral.com/track/pdf/10.1186/1471-2164-10-115?site=bmcgenomics.biomedcentral.com

S. Miethe, T. Meyer, S. Wöhl-bruhn, A. Frenzel, T. Schirrmann et al., Production of single chain fragment variable (scFv) antibodies in Escherichia coli using the LEX??? bioreactor, Journal of Biotechnology, vol.163, issue.2, pp.105-116, 2013.
DOI : 10.1016/j.jbiotec.2012.07.011

C. Rasetti-escargueil, Y. Liu, P. Rigsby, R. Jones, and D. Sesardic, Phrenic nerve-hemidiaphragm as a highly sensitive replacement assay for determination of functional botulinum toxin antibodies, Toxicon, vol.57, issue.7-8, pp.1008-1024, 2011.
DOI : 10.1016/j.toxicon.2011.04.003

E. Laffly, T. Pelat, F. Cédrone, S. Blésa, H. Bedouelle et al., Improvement of an Antibody Neutralizing the Anthrax Toxin by Simultaneous Mutagenesis of Its Six Hypervariable Loops, Journal of Molecular Biology, vol.378, issue.5, pp.1094-103, 2008.
DOI : 10.1016/j.jmb.2008.03.045

R. National and . Council, Guide for the Care; Use of Laboratory Animals, 2011.

M. Tavallaie, A. Chenal, D. Gillet, Y. Pereira, M. Manich et al., Interaction between the two subdomains of the C-terminal part of the botulinum neurotoxin A is essential for the generation of protective antibodies, FEBS Letters, vol.23, issue.1-3, pp.299-306, 2004.
DOI : 10.1023/B:JOPC.0000016257.91979.06

T. Pelat, M. Hust, and P. Thullier, Obtention and Engineering of Non-Human Primate (NHP) Antibodies for Therapeutics, Mini-Reviews in Medicinal Chemistry, vol.9, issue.14, pp.1633-1641, 2009.
DOI : 10.2174/138955709791012283

A. Frenzel, J. Kügler, S. Wilke, T. Schirrmann, and M. Hust, Construction of Human Antibody Gene Libraries and Selection of Antibodies by Phage Display, Methods Mol Biol, vol.1060, pp.215-258, 2014.
DOI : 10.1007/978-1-62703-586-6_12

P. Schuck and A. Minton, Analysis of Mass Transport-Limited Binding Kinetics in Evanescent Wave Biosensors, Analytical Biochemistry, vol.240, issue.2, pp.262-72, 1996.
DOI : 10.1006/abio.1996.0356

E. Alamyar, V. Giudicelli, S. Li, P. Duroux, M. Lefranc et al., HighV-QUEST: the IMGT® web portal for immunoglobulin (IG) or antibody and T cell receptor (TR) analysis from NGS high throughput and deep sequencing, Immunome Res, vol.8, p.26, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00722909

F. Ehrenmann, M. Lefranc, and . Imgt, IMGT/DomainGapAlign: The IMGT?? Tool for the Analysis of IG, TR, MH, IgSF, and MhSF Domain Amino Acid Polymorphism, Methods Mol Biol, vol.882, pp.605-638, 2012.
DOI : 10.1007/978-1-61779-842-9_33

URL : https://hal.archives-ouvertes.fr/hal-00722914

C. Rasetti-escargueil, R. Jones, Y. Liu, and D. Sesardic, Measurement of botulinum types A, B and E neurotoxicity using the phrenic nerve???hemidiaphragm: Improved precision with in-bred mice, Toxicon, vol.53, issue.5, pp.503-514, 2009.
DOI : 10.1016/j.toxicon.2009.01.019