D. Lacy and R. Stevens, Sequence homology and structural analysis of the clostridial neurotoxins, Journal of Molecular Biology, vol.291, issue.5, pp.1091-1042945, 1999.
DOI : 10.1006/jmbi.1999.2945

T. Smith, J. Lou, I. Geren, C. Forsyth, R. Tsai et al., Sequence Variation within Botulinum Neurotoxin Serotypes Impacts Antibody Binding and Neutralization, Infection and Immunity, vol.73, issue.9, pp.5450-5457, 2005.
DOI : 10.1128/IAI.73.9.5450-5457.2005

URL : http://iai.asm.org/content/73/9/5450.full.pdf

S. Arnon, R. Schechter, T. Inglesby, D. Henderson, J. Bartlett et al., Botulinum Toxin as a Biological Weapon, JAMA, vol.285, issue.8, pp.1059-70, 2001.
DOI : 10.1001/jama.285.8.1059

T. Gelzleichter, M. Myers, R. Menton, N. Niemuth, M. Matthews et al., Protection against botulinum toxins provided by passive immunization with botulinum human immune globulin: evaluation using an inhalation model, Journal of Applied Toxicology, vol.19, issue.S1, 1999.
DOI : 10.1002/(SICI)1099-1263(199912)19:1+<S35::AID-JAT612>3.0.CO;2-9

D. Gill, Bacterial toxins: a table of lethal amounts, Microbiol Rev, vol.46, pp.86-946806598, 1982.

A. Scott and D. Suzuki, Systemic toxicity of botulinum toxin by intramuscular injection in the monkey, Movement Disorders, vol.6, issue.4, pp.333-338, 1988.
DOI : 10.1017/S031716710003540X

L. Taysse, S. Daulon, J. Calvet, S. Delamanche, D. Hilaire et al., Induction of Acute Lung Injury after Intranasal Administration of Toxin Botulinum A Complex, Toxicologic Pathology, vol.33, issue.3, pp.336-378, 2005.
DOI : 10.1002/path.1711680403

L. Wein and Y. Liu, Analyzing a bioterror attack on the food supply: The case of botulinum toxin in milk, Proceedings of the National Academy of Sciences, vol.334, issue.20, pp.9984-9993, 2005.
DOI : 10.1056/NEJM199605163342001

E. Schantz and E. Johnson, Properties and use of botulinum toxin and other microbial neurotoxins in medicine, Microbiol Rev, vol.56, pp.80-991579114, 1992.

K. Hill, T. Smith, C. Helma, L. Ticknor, B. Foley et al., Genetic Diversity among Botulinum Neurotoxin-Producing Clostridial Strains, Journal of Bacteriology, vol.189, issue.3, pp.818-3201180, 2007.
DOI : 10.1128/JB.01180-06

URL : http://jb.asm.org/content/189/3/818.full.pdf

S. Kalb, J. Baudys, J. Rees, T. Smith, L. Smith et al., De novo subtype and strain identification of botulinum neurotoxin type B through toxin proteomics, Analytical and Bioanalytical Chemistry, vol.31, issue.13, pp.215-241, 2012.
DOI : 10.1093/infdis/31.6.559

URL : https://link.springer.com/content/pdf/10.1007%2Fs00216-012-5767-3.pdf

T. Smith, K. Hill, B. Foley, J. Detter, A. Munk et al., Analysis of the Neurotoxin Complex Genes in Clostridium botulinum A1-A4 and B1 Strains: BoNT/A3, /Ba4 and /B1 Clusters Are Located within Plasmids, PLoS ONE, vol.63, issue.12, 1271.
DOI : 10.1371/journal.pone.0001271.t003

URL : https://doi.org/10.1371/journal.pone.0001271

J. Black and J. Dolly, Interaction of 125I-labeled botulinum neurotoxins with nerve terminals. II. Autoradiographic evidence for its uptake into motor nerves by acceptor-mediated endocytosis, The Journal of Cell Biology, vol.103, issue.2, pp.535-579, 1986.
DOI : 10.1083/jcb.103.2.535

URL : http://jcb.rupress.org/content/jcb/103/2/535.full.pdf

O. Rossetto and C. Montecucco, Presynaptic Neurotoxins with Enzymatic Activities, Handb Exp Pharmacol, vol.184, pp.129-70978, 2008.
DOI : 10.1007/978-3-540-74805-2_6

G. Schiavo, F. Benfenati, B. Poulain, O. Rossetto, P. De-laureto et al., Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin, Nature, vol.359, issue.6398, pp.832-837, 1992.
DOI : 10.1038/359832a0

G. Schiavo, M. Matteoli, and C. Montecucco, Neurotoxins Affecting Neuroexocytosis, Physiological Reviews, vol.267, issue.2, pp.717-6610747206, 2000.
DOI : 10.1007/BF00498693

N. Mahant, P. Clouston, and I. Lorentz, The current use of botulinum toxin, Journal of Clinical Neuroscience, vol.7, issue.5, pp.389-94, 2000.
DOI : 10.1054/jocn.2000.0684

D. Dressler, S. Paus, A. Seitzinger, B. Gebhardt, and A. Kupsch, Long-term efficacy and safety of incobotulinumtoxinA injections in patients with cervical dystonia, Journal of Neurology, Neurosurgery & Psychiatry, vol.43, issue.Suppl 1, pp.1014-1023, 2013.
DOI : 10.2340/16501977-0796

URL : http://jnnp.bmj.com/content/jnnp/84/9/1014.full.pdf

E. Lim and R. Seet, Use of botulinum toxin in the neurology clinic, Nature Reviews Neurology, vol.19, issue.11, pp.624-660, 2010.
DOI : 10.1288/00005537-199109000-00006

D. Franz, P. Jahrling, A. Friedlander, D. Mcclain, D. Hoover et al., Clinical Recognition and Management of Patients Exposed to Biological Warfare Agents, JAMA: The Journal of the American Medical Association, vol.278, issue.5, pp.399-41103550050061035, 1997.
DOI : 10.1001/jama.1997.03550050061035

S. Arnon, R. Schechter, S. Maslanka, N. Jewell, and C. Hatheway, Human Botulism Immune Globulin for the Treatment of Infant Botulism, New England Journal of Medicine, vol.354, issue.5, pp.462-71, 2006.
DOI : 10.1056/NEJMoa051926

R. Black and R. Gunn, Hypersensitivity reactions associated with botulinal antitoxin, The American Journal of Medicine, vol.69, issue.4, pp.567-700002, 1980.
DOI : 10.1016/0002-9343(80)90469-6

S. Kalb, W. Santana, I. Geren, C. Garcia-rodriguez, J. Lou et al., Extraction and inhibition of enzymatic activity of botulinum neurotoxins /B1, /B2, /B3, /B4, and /B5 by a panel of monoclonal anti-BoNT/B antibodies, BMC Biochemistry, vol.12, issue.1, p.58, 2011.
DOI : 10.1016/j.jmb.2006.09.084

S. Adekar, R. Jones, M. Elias, F. Saleem, M. Root et al., Hybridoma populations enriched for affinity-matured human IgGs yield high-affinity antibodies specific for botulinum neurotoxins, Journal of Immunological Methods, vol.333, issue.1-2, pp.156-66, 2008.
DOI : 10.1016/j.jim.2008.01.015

P. Amersdorfer, C. Wong, T. Smith, S. Chen, S. Deshpande et al., Genetic and immunological comparison of anti-botulinum type A antibodies from immune and non-immune human phage libraries, Vaccine, vol.20, issue.11-12, pp.1640-1648, 2002.
DOI : 10.1016/S0264-410X(01)00482-0

C. Rasetti-escargueil, Y. Liu, P. Rigsby, R. Jones, and D. Sesardic, Phrenic nerve-hemidiaphragm as a highly sensitive replacement assay for determination of functional botulinum toxin antibodies, Toxicon, vol.57, issue.7-8, pp.1008-1024, 2011.
DOI : 10.1016/j.toxicon.2011.04.003

R. Jones, T. Alsop, R. Hull, R. Tierney, P. Rigsby et al., Botulinum type A toxin neutralisation by specific IgG and its fragments: A comparison of mouse systemic toxicity and local flaccid paralysis assays, Toxicon, vol.48, issue.3, pp.246-54, 2006.
DOI : 10.1016/j.toxicon.2006.05.007

H. Zhou, B. Zhou, S. Pellett, E. Johnson, and K. Janda, Selection and characterization of a human monoclonal neutralizing antibody for Clostridium Botulinum neurotoxin serotype B, Bioorganic & Medicinal Chemistry Letters, vol.19, issue.3, pp.662-666, 2009.
DOI : 10.1016/j.bmcl.2008.12.055

URL : http://europepmc.org/articles/pmc2645068?pdf=render

C. Garcia-rodriguez, I. Geren, J. Lou, F. Conrad, C. Forsyth et al., Neutralizing human monoclonal antibodies binding multiple serotypes of botulinum neurotoxin, Protein Engineering Design and Selection, vol.564, issue.1-2, pp.321-352, 2011.
DOI : 10.1016/S0014-5793(04)00309-6

URL : https://academic.oup.com/peds/article-pdf/24/3/321/4491727/gzq111.pdf

P. Thullier, S. Chahboun, and T. Pelat, ) immunoglobulin germline V regions and its implications for antibody engineering, mAbs, vol.2, issue.5, pp.528-566, 2010.
DOI : 10.1126/science.1139247

URL : http://www.tandfonline.com/doi/pdf/10.4161/mabs.2.5.12545?needAccess=true

S. Chahboun, M. Hust, Y. Liu, T. Pelat, S. Miethe et al., Isolation of a nanomolar scFv inhibiting the endopeptidase activity of botulinum toxin A, by single-round panning of an immune phage-displayed library of macaque origin, BMC Biotechnology, vol.11, issue.1, 2011.
DOI : 10.1186/1472-6750-11-113

C. Rasetti-escargueil, R. Jones, Y. Liu, and D. Sesardic, Measurement of botulinum types A, B and E neurotoxicity using the phrenic nerve???hemidiaphragm: Improved precision with in-bred mice, Toxicon, vol.53, issue.5, pp.503-514, 2009.
DOI : 10.1016/j.toxicon.2009.01.019

C. Rasetti-escargueil, C. Machado, R. Preneta-blanc, R. Fleck, and D. Sesardic, Enhanced sensitivity to Botulinum type A neurotoxin of human neuroblastoma SH-SY5Y cells after differentiation into mature neuronal cells, The Botulinum J., vol.2, issue.1, pp.30-48, 2011.
DOI : 10.1504/TBJ.2011.041814

M. Atassi and B. Dolimbek, -Domain (Residues 449???859) of Botulinum Neurotoxin A with Antitoxin Antibodies from Four Host Species. Full Profile of the Continuous Antigenic Regions of the H-Chain of Botulinum Neurotoxin A, The Protein Journal, vol.23, issue.1, pp.39-52, 2004.
DOI : 10.1023/B:JOPC.0000016257.91979.06

M. Tavallaie, A. Chenal, D. Gillet, Y. Pereira, M. Manich et al., Interaction between the two subdomains of the C-terminal part of the botulinum neurotoxin A is essential for the generation of protective antibodies, FEBS Letters, vol.23, issue.1-3, pp.299-306, 2004.
DOI : 10.1023/B:JOPC.0000016257.91979.06

S. Adekar, T. Takahashi, R. Jones, F. Saleem, D. Ancharski et al., Neutralization of Botulinum Neurotoxin by a Human Monoclonal Antibody Specific for the Catalytic Light Chain, PLoS ONE, vol.304, issue.8, 2008.
DOI : 10.1371/journal.pone.0003023.t002

A. Avril, J. Froude, J. Mathieu, T. Pelat, and P. Thullier, Isolation of Antibodies From Non-Human Primates for Clinical Use, Current Drug Discovery Technologies, vol.11, issue.1, pp.20-27, 2014.
DOI : 10.2174/15701638113109990030

P. Thullier, O. Huish, T. Pelat, and A. Martin, The Humanness of Macaque Antibody Sequences, Journal of Molecular Biology, vol.396, issue.5, pp.1439-50, 2010.
DOI : 10.1016/j.jmb.2009.12.041

URL : http://acrmwww.biochem.ucl.ac.uk/publications/freepdf/macaque_submit.pdf

T. Pelat, M. Hust, M. Hale, M. Lefranc, S. Thullier et al., Isolation of a human-like antibody fragment (scFv) that neutralizes ricin biological activity, BMC Biotechnology, vol.9, issue.1, p.60, 2009.
DOI : 10.1186/1472-6750-9-60

URL : https://hal.archives-ouvertes.fr/hal-00410069

E. Laffly, L. Danjou, F. Condemine, D. Vidal, E. Drouet et al., Selection of a Macaque Fab with Framework Regions Like Those in Humans, High Affinity, and Ability To Neutralize the Protective Antigen (PA) of Bacillus anthracis by Binding to the Segment of PA between Residues 686 and 694, Antimicrobial Agents and Chemotherapy, vol.49, issue.8, pp.3414-3434, 2005.
DOI : 10.1128/AAC.49.8.3414-3420.2005

T. R?-ulker, L. Voß, P. Thullier, O. Brien, L. Pelat et al., Isolation and characterisation of a human-like antibody fragment (scFv) that inactivates VEEV in vitro and in vivo, PloS ONE, vol.7, issue.e37242, 2012.

C. Garcia-rodriguez, R. Levy, J. Arndt, C. Forsyth, A. Razai et al., Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin, Nature Biotechnology, vol.16, issue.1, pp.107-123, 2007.
DOI : 10.1021/bp990133s

S. Kalb, J. Lou, C. Garcia-rodriguez, I. Geren, T. Smith et al., Extraction and Inhibition of Enzymatic Activity of Botulinum Neurotoxins/A1, /A2, and /A3 by a Panel of Monoclonal Anti-BoNT/A Antibodies, PLoS ONE, vol.5, issue.10, p.5355, 2009.
DOI : 10.1371/journal.pone.0005355.t003

S. Kalb, C. Garcia-rodriguez, J. Lou, J. Baudys, T. Smith et al., Extraction of BoNT/A, /B, /E, and /F with a Single, High Affinity Monoclonal Antibody for Detection of Botulinum Neurotoxin by Endopep-MS, PLoS ONE, vol.189, issue.23, 2010.
DOI : 10.1371/journal.pone.0012237.t002

A. Razai, C. Garcia-rodriguez, J. Lou, I. Geren, C. Forsyth et al., Molecular Evolution of Antibody Affinity for Sensitive Detection of Botulinum Neurotoxin Type A, Journal of Molecular Biology, vol.351, issue.1, pp.158-69, 2005.
DOI : 10.1016/j.jmb.2005.06.003

A. Nowakowski, C. Wang, D. Powers, P. Amersdorfer, T. Smith et al., Potent neutralization of botulinum neurotoxin by recombinant oligoclonal antibody, Proceedings of the National Academy of Sciences, vol.287, issue.5458, pp.11346-50, 2002.
DOI : 10.1126/science.287.5458.1664

URL : http://www.pnas.org/content/99/17/11346.full.pdf

J. Sepulveda, J. Mukherjee, S. Tzipori, L. Simpson, and C. Shoemaker, Efficient Serum Clearance of Botulinum Neurotoxin Achieved Using a Pool of Small Antitoxin Binding Agents, Infection and Immunity, vol.78, issue.2, pp.756-763, 2010.
DOI : 10.1128/IAI.01084-09

J. Mukherjee, J. Tremblay, C. Leysath, K. Ofori, K. Baldwin et al., A Novel Strategy for Development of Recombinant Antitoxin Therapeutics Tested in a Mouse Botulism Model, PLoS ONE, vol.324, issue.6, 2012.
DOI : 10.1371/journal.pone.0029941.s006

E. Diamant, B. Lachmi, K. A. Barnea, A. Marcuk, H. Cohen et al., Evaluating the Synergistic Neutralizing Effect of Anti-Botulinum Oligoclonal Antibody Preparations, PLoS ONE, vol.7, issue.1, p.87089, 2014.
DOI : 10.1371/journal.pone.0087089.s004

URL : https://doi.org/10.1371/journal.pone.0087089

S. Miethe, C. Rasetti-escargueil, Y. Liu, S. Chahboun, T. Pelat et al., Development of neutralizing scFv-Fc against botulinum neurotoxin A light chain from a macaque immune library, mAbs, vol.57, issue.2, pp.446-459, 2014.
DOI : 10.1038/2338

URL : http://www.tandfonline.com/doi/pdf/10.4161/mabs.27773?needAccess=true

K. Abhinandan and A. Martin, Analyzing the ???Degree of Humanness??? of Antibody Sequences, Journal of Molecular Biology, vol.369, issue.3, pp.852-62, 2007.
DOI : 10.1016/j.jmb.2007.02.100

T. Pelat, M. Hust, and P. Thullier, Obtention and Engineering of Non-Human Primate (NHP) Antibodies for Therapeutics, Mini-Reviews in Medicinal Chemistry, vol.9, issue.14, pp.1633-1641, 2009.
DOI : 10.2174/138955709791012283

T. Pelat, H. Bedouelle, A. Rees, S. Crennell, M. Lefranc et al., Germline Humanization of a Non-human Primate Antibody that Neutralizes the Anthrax Toxin, by in Vitro and in Silico Engineering, Journal of Molecular Biology, vol.384, issue.5, pp.1400-1407, 2008.
DOI : 10.1016/j.jmb.2008.10.033

URL : https://hal.archives-ouvertes.fr/hal-00345933

C. Mazuet, J. Dano, M. Popoff, C. Creminon, and H. Volland, Characterization of Botulinum Neurotoxin Type A Neutralizing Monoclonal Antibodies and Influence of Their Half-Lives on Therapeutic Activity, PLoS ONE, vol.13, issue.8, 2010.
DOI : 10.1371/journal.pone.0012416.s003

URL : https://hal.archives-ouvertes.fr/pasteur-01762095

C. Shone and H. Tranter, Growth of Clostridia and Preparation of Their Neurotoxins, Clostridial neurotoxins, pp.143-160, 1995.
DOI : 10.1007/978-3-642-85173-5_7

G. Ferracci, S. Marconi, C. Mazuet, E. Jover, M. Blanchard et al., A label-free biosensor assay for botulinum neurotoxin B in food and human serum, Analytical Biochemistry, vol.410, issue.2, pp.281-288, 2011.
DOI : 10.1016/j.ab.2010.11.045

URL : https://hal.archives-ouvertes.fr/hal-00751523

M. Hust and N. J. Sclifton, Phage Display Vectors for the In Vitro Generation of Human Antibody Fragments, Methods Mol Biol, vol.295, pp.71-9615596889, 2005.
DOI : 10.1385/1-59259-873-0:071

M. Sch?-utte, P. Thullier, T. Pelat, X. Wezler, P. Rosenstock et al., Identification of a Putative Crf Splice Variant and Generation of Recombinant Antibodies for the Specific Detection of Aspergillus fumigatus, PLoS ONE, vol.202, issue.8, p.6625, 2009.
DOI : 10.1371/journal.pone.0006625.t003

A. Frenzel, J. K?-ugler, S. Wilke, T. Schirrmann, and . Hust, Construction of Human Antibody Gene Libraries and Selection of Antibodies by Phage Display, Methods Mol Biol, vol.1060, pp.215-43978, 2014.
DOI : 10.1007/978-1-62703-586-6_12

T. Pelat, M. Hust, E. Laffly, F. Condemine, C. Bottex et al., High-Affinity, Human Antibody-Like Antibody Fragment (Single-Chain Variable Fragment) Neutralizing the Lethal Factor (LF) of Bacillus anthracis by Inhibiting Protective Antigen-LF Complex Formation, Antimicrobial Agents and Chemotherapy, vol.51, issue.8, pp.2758-6401528, 2007.
DOI : 10.1128/AAC.01528-06

URL : http://aac.asm.org/content/51/8/2758.full.pdf

V. J?-ager, K. B?-ussow, A. Wagner, S. Weber, M. Hust et al., High level transient production of recombinant antibodies and antibody fusion proteins in HEK293 cells, BMC Biotechnology, vol.13, issue.1, p.52, 2013.
DOI : 10.1038/nbt0102-87

P. Schuck and A. Minton, Analysis of mass transport-limited binding kinetics in evenescent wave biosensors, Anal Biochem, vol.2408811920, pp.262-2720356, 1996.
DOI : 10.1006/abio.1996.0356

E. Alamyar, P. Duroux, M. Lefranc, and V. Giudicelli, IMGT?? Tools for the Nucleotide Analysis of Immunoglobulin (IG) and T Cell Receptor (TR) V-(D)-J Repertoires, Polymorphisms, and IG Mutations: IMGT/V-QUEST and IMGT/HighV-QUEST for NGS, Methods Mol Biol, vol.882, pp.569-604, 2012.
DOI : 10.1007/978-1-61779-842-9_32

URL : https://hal.archives-ouvertes.fr/hal-00722893

F. Ehrenmann and M. Lefranc, IMGT/DomainGapAlign: The IMGT?? Tool for the Analysis of IG, TR, MH, IgSF, and MhSF Domain Amino Acid Polymorphism, Methods Mol Biol, vol.882, pp.605-33978, 2012.
DOI : 10.1007/978-1-61779-842-9_33

URL : https://hal.archives-ouvertes.fr/hal-00722914

M. Lefranc, F. Ehrenmann, C. Ginestoux, V. Giudicelli, and P. Duroux, Use of IMGT?? Databases and Tools for Antibody Engineering and Humanization, Methods Mol Biol, vol.907, pp.3-37978, 2012.
DOI : 10.1007/978-1-61779-974-7_1

URL : https://hal.archives-ouvertes.fr/hal-00742879

R. Jones, M. Ochiai, Y. Liu, T. Ekong, and D. Sesardic, Development of improved SNAP25 endopeptidase immuno-assays for botulinum type A and E toxins, Journal of Immunological Methods, vol.329, issue.1-2, pp.92-101, 2008.
DOI : 10.1016/j.jim.2007.09.014

D. Sesardic, K. Mclellen, T. Ekong, and R. Das, Refinement and Validation of an Alternative Bioassay for Potency Testing of Therapeutic Botulinum Type A Toxin, Pharmacology & Toxicology, vol.43, issue.5, pp.283-291, 1996.
DOI : 10.7883/yoken1952.43.163

D. Sesardic, R. Jones, T. Leung, T. Alsop, and R. Tierney, Detection of antibodies against botulinum toxins, Movement Disorders, vol.101, issue.S8, pp.85-91, 2004.
DOI : 10.1016/S0041-0101(01)00288-4