T-cell biomarkers for diagnosis of tuberculosis: candidate evaluation by a simple whole blood assay for clinical translation

Munyaradzi Musvosvi (1) , Darragh Duffy (2) , Elizabeth Filander (1) , Hadn Africa (1) , Simbarashe Mabwe (1) , Lungisa Jaxa (1) , Nicole Bilek (1) , Alba Llibre (2) , Vincent Rouilly (2) , Mark Hatherill (1) , Matthew Albert (2, 3) , Thomas Scriba (1) , Elisa Nemes (1)

1 University of Cape Town
2 Immunobiologie des Cellules dendritiques
3 Genentech, Inc. [San Francisco]

We compared candidate T-cell-based TB biomarkers and identified HLA-DR on Mtb-specific T-cells as a priority marker http://ow.ly/TyHa30iwVbL

Keywords: Respiratory infections; tuberculosis

Domains: Immunology

Munyaradzi Musvosvi, Darragh Duffy, Elizabeth Filander, Hadn Africa, Simbarashe Mabwe, et al.. T-cell biomarkers for diagnosis of tuberculosis: candidate evaluation by a simple whole blood assay for clinical translation. European Respiratory Journal, 2018, 51 (3), pp.1800153. ⟨10.1183/13993003.00153-2018⟩. ⟨pasteur-01770019⟩