C. Z. Bachrati, I. D. Hickson, J. Barrowman, P. A. Wiley, S. E. Hudon-miller et al., RecQ helicases: Suppressors of tumorigenesis and premature aging https://doi.org/10 Human ZMPSTE24 disease mutations: Residual proteolytic activity correlates with disease severity, Biochemical Journal Human Molecular Genetics J. H, vol.374, issue.21, pp.577-606, 1042.

Y. Begus-nahrmann, A. Lechel, A. C. Obenauf, K. Nalapareddy, E. Peit et al., p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice, Nature Genetics, vol.94, issue.10, pp.1138-1143, 2009.
DOI : 10.1038/ng.426

M. O. Bergo, B. Gavino, J. Ross, W. K. Schmidt, C. Hong et al., Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect, Proceedings of the National Academy of Sciences, pp.13049-13054, 2002.
DOI : 10.1002/ajmg.1463

G. Blander, N. Zalle, J. F. Leal, R. L. Bar-or, C. E. Yu et al., The Werner syndrome protein contributes to induction of p53 by DNA damage, The FASEB Journal, vol.14, issue.14, pp.2138-2140, 2000.
DOI : 10.1096/fj.00-0171fje

R. Burla, M. Carcuro, L. Torre, M. Fratini, F. Crescenzi et al., The telomeric protein AKTIP interacts with Aand B-type lamins and is involved in regulation of cellular senescence, Open Biology, vol.6, 2016.

R. Burla, M. Carcuro, G. D. Raffa, A. Galati, D. Raimondo et al., AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance, PLOS Genetics, vol.27, issue.3, 2015.
DOI : 10.1371/journal.pgen.1005167.s009

R. Burla, L. Torre, M. Saggio, and I. , Mammalian telomeres and their partnership with lamins, Nucleus, vol.31, issue.21, pp.187-202, 2016.
DOI : 10.1083/jcb.200407178

H. Cao and R. A. Hegele, LMNA is mutated in Hutchinson-Gilford progeria (MIM 176670) but not in Wiedemann-Rautenstrauch progeroid syndrome (MIM 264090), Journal of Human Genetics, vol.48, issue.5, pp.271-274, 2003.
DOI : 10.1007/s10038-003-0025-3

L. Cao, W. Li, S. Kim, S. G. Brodie, and C. X. Deng, Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform, Genes & Development, vol.17, issue.2, pp.201-213, 2003.
DOI : 10.1101/gad.1050003

B. Cecchinelli, A. Porrello, C. Lazzari, A. Gradi, G. Bossi et al., Ser58 of mouse p53 is the homologue of human Ser46 and is phosphorylated by HIPK2 in apoptosis, Cell Death and Differentiation, vol.206, issue.11, 1994.
DOI : 10.1128/MCB.8.1.461

G. Cenci, L. Ciapponi, M. Marzullo, G. D. Raffa, P. Morciano et al., The Analysis of Pendolino (peo) Mutants Reveals Differences in the Fusigenic Potential among Drosophila Telomeres, PLOS Genetics, vol.21, issue.6, 2015.
DOI : 10.1371/journal.pgen.1005260.s004

C. Y. Chen, Y. H. Chi, R. A. Mutalif, M. F. Starost, T. G. Myers et al., Accumulation of the Inner Nuclear Envelope Protein Sun1 Is Pathogenic in Progeric and Dystrophic Laminopathies, Cell, vol.149, issue.3, pp.565-577, 2012.
DOI : 10.1016/j.cell.2012.01.059

J. De-la-rosa, J. M. Freije, R. Cabanillas, F. G. Osorio, M. F. Fraga et al., Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion, Nature Communications, vol.12, 2013.
DOI : 10.1073/pnas.0506580102

D. Sandre-giovannoli, A. Bernard, R. Cau, P. Navarro, C. Amiel et al., Lamin A Truncation in Hutchinson-Gilford Progeria, Science, vol.300, issue.5628, 2003.
DOI : 10.1126/science.1084125

I. Dokal, Dyskeratosis congenita. Hematology/the Education Program of the, pp.480-486, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00486072

Y. Doksani and T. De-lange, The Role of Double-Strand Break Repair Pathways at Functional and Dysfunctional Telomeres, Cold Spring Harbor Perspectives in Biology, vol.6, issue.12, 2014.
DOI : 10.1101/cshperspect.a016576

C. Dudgeon, C. Chan, W. Kang, Y. Sun, R. Emerson et al., The evolution of thymic lymphomas in p53 knockout mice, Genes & Development, vol.28, issue.23, pp.2613-2620, 2014.
DOI : 10.1101/gad.252148.114

S. Gonzalo and R. Kreienkamp, DNA repair defects and genome instability in Hutchinson???Gilford Progeria Syndrome, Current Opinion in Cell Biology, vol.34, pp.75-83, 2015.
DOI : 10.1016/j.ceb.2015.05.007
URL : http://europepmc.org/articles/pmc4522337?pdf=render

R. C. Hennekam, Hutchinson???Gilford progeria syndrome: Review of the phenotype, American Journal of Medical Genetics Part A, vol.81, issue.23, pp.2603-26241552, 2006.
DOI : 10.1016/S1388-1981(02)00342-6

M. X. Ibrahim, V. I. Sayin, M. K. Akula, M. Liu, L. G. Fong et al., Targeting Isoprenylcysteine Methylation Ameliorates Disease in a Mouse Model of Progeria, Science, vol.3, issue.4, pp.1330-1333, 2013.
DOI : 10.1007/s12154-010-0041-7

T. Jacks, L. Remington, B. O. Williams, E. M. Schmitt, S. Halachmi et al., Tumor spectrum analysis in p53-mutant mice, Current Biology, vol.4, issue.1, pp.1-7, 1994.
DOI : 10.1016/S0960-9822(00)00002-6

G. A. Lang, T. Iwakuma, Y. A. Suh, G. Liu, V. A. Rao et al., Gain of Function of a p53 Hot Spot Mutation in a Mouse Model of Li-Fraumeni Syndrome, Cell, vol.119, issue.6, pp.861-872, 2004.
DOI : 10.1016/j.cell.2004.11.006

B. Liu, J. Wang, K. Chan, W. Tjia, W. Deng et al., Genomic instability in laminopathy-based premature aging, Nature Medicine, vol.278, issue.7, pp.780-785, 2005.
DOI : 10.1074/jbc.C300060200

C. Lopez-otin, M. A. Blasco, L. Partridge, M. Serrano, and G. Kroemer, The Hallmarks of Aging, Cell, vol.153, issue.6, pp.1194-1217, 2013.
DOI : 10.1016/j.cell.2013.05.039

X. Ma, S. N. Choudhury, X. Hua, Z. Dai, Y. Li et al., Interaction of the oncogenic miR-21 microRNA and the p53 tumor suppressor pathway, Carcinogenesis, vol.585, issue.Pt 20, pp.1216-1223, 2013.
DOI : 10.1016/j.febslet.2010.12.027

P. Mart-inez, M. Thanasoula, P. Mu~-noz, C. Liao, A. Tejera et al., Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice, Genes & Development, vol.23, issue.17, pp.2060-2075, 2009.
DOI : 10.1101/gad.543509

L. C. Mounkes, S. Kozlov, L. Hernandez, T. Sullivan, and C. L. Stewart, A progeroid syndrome in mice is caused by defects in A-type lamins, Nature, vol.144, issue.6937, pp.298-301, 2003.
DOI : 10.1083/jcb.144.4.631

F. G. Osorio, C. L. Navarro, J. Cadinanos, I. C. Lopez-mejia, P. M. Quiros et al., Lopez-Otin C. (2011) Splicing-directed therapy in a new mouse model of human accelerated aging, Science Translational Medicine, vol.3, pp.106-107

F. G. Osorio, A. P. Ugalde, G. Marino, X. S. Puente, J. M. Freije et al., Cell autonomous and systemic factors in progeria development: Figure 1., Biochemical Society Transactions, vol.2, issue.6, pp.1710-1714, 2011.
DOI : 10.1172/JCI43578

C. Rinaldo, A. Moncada, A. Gradi, L. Ciuffini, D. D-'eliseo et al., HIPK2 Controls Cytokinesis and Prevents Tetraploidization by Phosphorylating Histone H2B at the Midbody, Molecular Cell, vol.47, issue.1, pp.87-98, 2012.
DOI : 10.1016/j.molcel.2012.04.029

K. L. Rudolph, S. Chang, H. W. Lee, M. Blasco, G. J. Gottlieb et al., Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice, Cell, vol.96, issue.5, pp.701-712, 1999.
DOI : 10.1016/S0092-8674(00)80580-2
URL : https://doi.org/10.1016/s0092-8674(00)80580-2

H. Saeed, B. M. Abdallah, N. Ditzel, P. Catala-lehnen, W. Qiu et al., Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment, Journal of Bone and Mineral Research, vol.181, issue.(Pt 2), pp.1494-1505, 2011.
DOI : 10.4049/jimmunol.181.10.7400

P. Scaffidi and T. Misteli, Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing, Nature Cell Biology, vol.157, issue.4, pp.452-459, 2008.
DOI : 10.1016/S0002-9440(10)64807-9

A. Sfeir, S. T. Kosiyatrakul, D. Hockemeyer, S. L. Macrae, J. Karlseder et al., Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication, Cell, vol.138, issue.1, pp.90-103, 2009.
DOI : 10.1016/j.cell.2009.06.021

N. E. Sharpless, C. J. Sherr, G. Testa, J. Schaft, F. Van-der-hoeven et al., Forging a signature of in vivo senescence, Nature Reviews Cancer, vol.443, issue.7, pp.397-408, 1038.
DOI : 10.1038/cddis.2014.489

I. Varela, J. Cadinanos, A. M. Pendas, A. Gutierrez-fernandez, A. R. Folgueras et al., Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation, Nature, vol.4, issue.7058, pp.564-568, 2005.
DOI : 10.1016/S0960-9822(00)00002-6

L. A. Watson, L. A. Solomon, J. R. Li, Y. Jiang, M. Edwards et al., Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span, Journal of Clinical Investigation, vol.123, issue.5, pp.2049-2063, 2013.
DOI : 10.1172/JCI65634DS1

K. Yanger, Y. Zong, L. R. Maggs, S. N. Shapira, R. Maddipati et al., Robust cellular reprogramming occurs spontaneously during liver regeneration, Genes & Development, vol.27, issue.7, pp.719-724, 2013.
DOI : 10.1101/gad.207803.112
URL : http://genesdev.cshlp.org/content/27/7/719.full.pdf