ExoY, an actin-activated nucleotidyl cyclase toxin from P. aeruginosa: a minireview

Alexander Belyy (1) , Undine Mechold (1) , Louis Renault (2) , Daniel Ladant (1)

1 Biochimie des Interactions Macromoléculaires / Biochemistry of Macromolecular Interactions
2 I2BC - Institut de Biologie Intégrative de la Cellule

ExoY is one of four well-characterized Pseudomonas aeruginosa type 3 secretion system (T3SS) effectors. It is a nucleotidyl cyclase toxin that is inactive inside the bacteria, but becomes potently activated once it is delivered into the eukaryotic target cells. Recently, filamentous actin was identified as the eukaryotic cofactor that stimulates specifically ExoY enzymatic activity by several orders of magnitude. In this review, we discuss recent advances in understanding the biochemistry of nucleotidyl cyclase activity of ExoY and its regulation by interaction with filamentous actin.

Keywords: Actin; Bacterial protein toxin; ExoY; Pseudomonas aeruginosa; T3SS

Domains: Bacteriology

Alexander Belyy, Undine Mechold, Louis Renault, Daniel Ladant. ExoY, an actin-activated nucleotidyl cyclase toxin from P. aeruginosa: a minireview. Toxicon, 2017, ⟨10.1016/j.toxicon.2017.12.046⟩. ⟨pasteur-01765203⟩