ExoY, an actin-activated nucleotidyl cyclase toxin from P. aeruginosa: a minireview - Archive ouverte HAL Access content directly
Journal Articles Toxicon Year : 2017

ExoY, an actin-activated nucleotidyl cyclase toxin from P. aeruginosa: a minireview

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Abstract

ExoY is one of four well-characterized Pseudomonas aeruginosa type 3 secretion system (T3SS) effectors. It is a nucleotidyl cyclase toxin that is inactive inside the bacteria, but becomes potently activated once it is delivered into the eukaryotic target cells. Recently, filamentous actin was identified as the eukaryotic cofactor that stimulates specifically ExoY enzymatic activity by several orders of magnitude. In this review, we discuss recent advances in understanding the biochemistry of nucleotidyl cyclase activity of ExoY and its regulation by interaction with filamentous actin.
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pasteur-01765203 , version 1 (12-04-2018)

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Alexander Belyy, Undine Mechold, Louis Renault, Daniel Ladant. ExoY, an actin-activated nucleotidyl cyclase toxin from P. aeruginosa: a minireview. Toxicon, 2017, ⟨10.1016/j.toxicon.2017.12.046⟩. ⟨pasteur-01765203⟩
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