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Toxin Detection in Patients' Sera by Mass Spectrometry during Two Outbreaks of Type A Botulism in France

Abstract : In two outbreaks of food-borne botulism in France, Clostridium botulinum type A was isolated and characterized from incriminated foods. Botulinum neurotoxin type A was detected in the patients' sera by mouse bioassay and in vitro endopeptidase assay with an immunocapture step and identification of the cleavage products by mass spectrometry.
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Submitted on : Tuesday, April 10, 2018 - 3:28:29 PM
Last modification on : Monday, June 1, 2020 - 2:34:08 PM

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Christelle Mazuet, Eric Ezan, Hervé Volland, Michel Robert Popoff, François Becher. Toxin Detection in Patients' Sera by Mass Spectrometry during Two Outbreaks of Type A Botulism in France. Journal of Clinical Microbiology, American Society for Microbiology, 2012, 50 (12), pp.4091 - 4094. ⟨10.1128/JCM.02392-12⟩. ⟨pasteur-01762967⟩

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