Binary Bacterial Toxins: Biochemistry, Biology, and Applications of Common Clostridium and Bacillus Proteins, Microbiology and Molecular Biology Reviews, vol.68, issue.3, pp.373-402, 2004. ,
DOI : 10.1128/MMBR.68.3.373-402.2004
URL : http://mmbr.asm.org/content/68/3/373.full.pdf
Histopathological effect of botulinum C2 toxin on mouse intestines, Infect Immun, vol.43, pp.54-58, 1984. ,
Purification and characterization of two components of botulinum C2 toxin, Infect Immun, vol.30, pp.668-673, 1980. ,
Response of mouse intestinal loop to botulinum C2 toxin: enterotoxic activity induced by cooperation of nonlinked protein components, Infect Immun, vol.40, pp.691-695, 1983. ,
Lethal and vascular permeability activities of botulinum C2 toxin induced by separate injections of the two toxin components, Infect Immun, vol.40, pp.336-339, 1983. ,
Alteration of the cytoskeleton of mammalian cells cultured in vitro by Clostridium botulinum C2 toxin and C3 ADP-ribosyltransferase, Eur J Cell Biol, vol.54, pp.237-245, 1991. ,
Purification and characterization of Clostridium perfringens iota toxin: dependence on two nonlinked proteins for biological activity, Infect Immun, vol.54, pp.683-688, 1986. ,
iota toxin ADP-ribosylates skeletal muscle actin in Arg-177, FEBS Letters, vol.75, issue.1-2, pp.48-52, 1987. ,
DOI : 10.1073/pnas.75.3.1106
URL : http://onlinelibrary.wiley.com/doi/10.1016/0014-5793(87)81129-8/pdf
Production of a complete binary toxin (actin-specific ADP-ribosyltransferase) by Clostridium difficile CD196, Infect Immun, vol.65, pp.1402-1407, 1997. ,
Actin-specific ADPribosyltransferase produced by a Clostridium difficile strain, Infect Immun, vol.56, pp.2299-2306, 1988. ,
Characterization of the Enzymatic Component of the ADP-Ribosyltransferase Toxin CDTa from Clostridium difficile, Infection and Immunity, vol.69, issue.10, pp.6004-6011, 2001. ,
DOI : 10.1128/IAI.69.10.6004-6011.2001
Clostridium spiroforme toxin is a binary toxin which ADP-ribosylates cellular actin, Biochemical and Biophysical Research Communications, vol.152, issue.3, pp.1361-1368, 1988. ,
DOI : 10.1016/S0006-291X(88)80435-2
Botulinum C2 toxin ADP-ribosylates actin, Nature, vol.85, issue.6077, pp.390-392, 1986. ,
DOI : 10.1038/322390a0
Botulinum C2 toxin ADP-ribosylates cytoplasmic beta/gamma-actin in arginine 177, J Biol Chem, vol.263, pp.696-700, 1988. ,
ADP-ribosylated actin caps the barbed ends of actin filaments, J Biol Chem, vol.263, pp.13739-13742, 1988. ,
ADP-ribosylation of actin by clostridial toxins, The Journal of Cell Biology, vol.109, issue.4, pp.1385-1387, 1989. ,
DOI : 10.1083/jcb.109.4.1385
URL : http://europepmc.org/articles/pmc2115792?pdf=render
Nonmuscle actin ADP-ribosylated by botulinum C2 toxin caps actin filaments, FEBS Letters, vol.225, issue.1-2, pp.181-184, 1989. ,
DOI : 10.1016/0014-5793(87)81129-8
URL : http://onlinelibrary.wiley.com/doi/10.1016/0014-5793(89)80279-0/pdf
Response of tissue-cultured cynomolgus monkey kidney cells to botulinum C2 toxin, Microbial Pathogenesis, vol.3, issue.4, pp.279-286, 1987. ,
DOI : 10.1016/0882-4010(87)90061-1
ADP-Ribosylation of Actin by the Clostridium botulinum C2 Toxin in Mammalian Cells Results in Delayed Caspase-Dependent Apoptotic Cell Death, Infection and Immunity, vol.76, issue.10, pp.4600-4608, 2008. ,
DOI : 10.1128/IAI.00651-08
The Long-Lived Nature of Clostridium perfringens Iota Toxin in Mammalian Cells Induces Delayed Apoptosis, Infection and Immunity, vol.77, issue.12, pp.5593-5601, 2009. ,
DOI : 10.1128/IAI.00710-09
URL : http://iai.asm.org/content/77/12/5593.full.pdf
New insights into the mode of action of the actin ADP-ribosylating virulence factors Salmonella enterica SpvB and Clostridium botulinum C2 toxin, European Journal of Cell Biology, vol.90, issue.11, 2011. ,
DOI : 10.1016/j.ejcb.2010.11.007
Characterization of Component-I Gene of Botulinum C2 Toxin and PCR Detection of Its Gene in Clostridial Species, Biochemical and Biophysical Research Communications, vol.220, issue.2, pp.353-359, 1996. ,
DOI : 10.1006/bbrc.1996.0409
C2 Toxin by Site-directed Mutagenesis, Journal of Biological Chemistry, vol.269, issue.45, pp.29506-29511, 1998. ,
DOI : 10.1073/pnas.85.20.7521
C2 Toxin Requires Oligomerization and Acidification, Journal of Biological Chemistry, vol.266, issue.25, pp.18704-18711, 2000. ,
DOI : 10.1038/385833a0
URL : http://www.jbc.org/content/275/25/18704.full.pdf
Functional Characterization of an Extended Binding Component of the Actin-ADP-Ribosylating C2 Toxin Detected in Clostridium botulinum Strain (C) 2300, Infection and Immunity, vol.78, issue.4, pp.1468-1474, 2010. ,
DOI : 10.1128/IAI.01351-09
The C Terminus of Component C2II of Clostridium botulinum C2 Toxin Is Essential for Receptor Binding, Infection and Immunity, vol.68, issue.8, pp.4566-4573, 2000. ,
DOI : 10.1128/IAI.68.8.4566-4573.2000
C2 Toxin to Asparagine-linked Complex and Hybrid Carbohydrates, Journal of Biological Chemistry, vol.266, issue.4, pp.2328-2334, 2000. ,
DOI : 10.1146/annurev.ge.18.120184.002521
URL : http://www.jbc.org/content/275/4/2328.full.pdf
Clostridium botulinum C2 toxin: binding studies with fluorescence-activated cytometry, Toxicon, vol.40, issue.8, pp.1135-1140, 2002. ,
DOI : 10.1016/S0041-0101(02)00113-7
Structure and Action of the Binary C2 Toxin from Clostridium botulinum, Journal of Molecular Biology, vol.364, issue.4, pp.705-715, 2006. ,
DOI : 10.1016/j.jmb.2006.09.002
Binding and Internalization of Clostridium botulinum C2 Toxin, Infection and Immunity, vol.77, issue.11, pp.5139-5148, 2009. ,
DOI : 10.1128/IAI.00638-09
URL : http://iai.asm.org/content/77/11/5139.full.pdf
Clostridium botulinum C2 toxin is internalized by clathrin- and Rho-dependent mechanisms, Cellular Microbiology, vol.76, issue.12, pp.1809-1820, 2010. ,
DOI : 10.1091/mbc.10.8.2687
URL : http://onlinelibrary.wiley.com/doi/10.1111/j.1462-5822.2010.01512.x/pdf
C2 Toxin into the Cytosol, Journal of Biological Chemistry, vol.269, issue.34, pp.32266-32274, 2003. ,
DOI : 10.1083/jcb.200210028
C2 toxin across membranes of acidified endosomes into the cytosol of mammalian cells, Cellular Microbiology, vol.54, issue.5, pp.780-795, 2009. ,
DOI : 10.1111/j.1365-2958.1997.tb02669.x
Interaction of Clostridium botulinum C2 toxin with lipid bilayer membranes. Formation of cation-selective channels and inhibition of channel function by chloroquine, J Biol Chem, vol.269, pp.16706-16711, 1994. ,
C2 toxin with lipid bilayer membranes and Vero cells: inhibition of channel function by chloroquine and related compounds in vitro and intoxification in vivo, The FASEB Journal, vol.15, issue.9, pp.1658-1660, 2001. ,
DOI : 10.1096/fj.00-0671fje
C2 Toxin, Journal of Biological Chemistry, vol.10, issue.39, pp.37360-37367, 2003. ,
DOI : 10.1074/jbc.M303980200
Cellular Uptake of the Clostridium perfringens Binary Iota-Toxin, Infection and Immunity, vol.69, issue.5, pp.2980-2987, 2001. ,
DOI : 10.1128/IAI.69.5.2980-2987.2001
Iota-Toxin with Lipid Bilayer Membranes, Journal of Biological Chemistry, vol.7, issue.8, pp.6143-6152, 2002. ,
DOI : 10.1038/385833a0
Blocking anthrax lethal toxin at the protective antigen channel by using structure-inspired drug design, Proceedings of the National Academy of Sciences, vol.52, issue.22, pp.15075-15080, 2005. ,
DOI : 10.1074/jbc.M401980200
URL : http://www.pnas.org/content/102/42/15075.full.pdf
Search for Cyclodextrin-Based Inhibitors of Anthrax Toxins: Synthesis, Structural Features, and Relative Activities, Antimicrobial Agents and Chemotherapy, vol.50, issue.11, pp.3740-3753, 2006. ,
DOI : 10.1128/AAC.00693-06
URL : http://aac.asm.org/content/50/11/3740.full.pdf
Inhibition of S. aureus ??-hemolysin and B. anthracis lethal toxin by ??-cyclodextrin derivatives, Bioorganic & Medicinal Chemistry, vol.15, issue.16, pp.5424-5431, 2007. ,
DOI : 10.1016/j.bmc.2007.05.058
Blockage of Anthrax PA63 Pore by a Multicharged High-Affinity Toxin Inhibitor, Biophysical Journal, vol.99, issue.1, pp.134-143, 2010. ,
DOI : 10.1016/j.bpj.2010.03.070
URL : https://doi.org/10.1016/j.bpj.2010.03.070
In Vivo Efficacy of ??-Cyclodextrin Derivatives against Anthrax Lethal Toxin, Antimicrobial Agents and Chemotherapy, vol.52, issue.6, pp.2239-2241, 2008. ,
DOI : 10.1128/AAC.00009-08
URL : http://aac.asm.org/content/52/6/2239.full.pdf
Prevention and Treatment of Staphylococcus aureus Pneumonia with a ??-Cyclodextrin Derivative, Antimicrobial Agents and Chemotherapy, vol.54, issue.1, pp.298-304, 2010. ,
DOI : 10.1128/AAC.00973-09
URL : http://aac.asm.org/content/54/1/298.full.pdf
Detergent-Resistant Membrane Microdomains Facilitate Ib Oligomer Formation and Biological Activity of Clostridium perfringens Iota-Toxin, Infection and Immunity, vol.72, issue.4, pp.2186-2193, 2004. ,
DOI : 10.1128/IAI.72.4.2186-2193.2004
URL : http://iai.asm.org/content/72/4/2186.full.pdf
Diphtheria toxin entry into cells is facilitated by low pH, The Journal of Cell Biology, vol.87, issue.3, pp.828-832, 1980. ,
DOI : 10.1083/jcb.87.3.828
URL : http://jcb.rupress.org/content/jcb/87/3/828.full.pdf
The Protective Antigen Component of Anthrax Toxin Forms Functional Octameric Complexes, Journal of Molecular Biology, vol.392, issue.3, pp.614-629, 2009. ,
DOI : 10.1016/j.jmb.2009.07.037
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742380
Anthrax toxin: channel-forming activity of protective antigen in planar phospholipid bilayers., Proceedings of the National Academy of Sciences, vol.86, issue.7, pp.2209-2213, 1989. ,
DOI : 10.1073/pnas.86.7.2209
URL : http://www.pnas.org/content/86/7/2209.full.pdf
Voltage-dependent block of anthrax toxin channels in planar phospholipid bilayer membranes by symmetric tetraalkylammonium ions. Effects on macroscopic conductance, The Journal of General Physiology, vol.96, issue.5, pp.905-919, 1990. ,
DOI : 10.1085/jgp.96.5.905
Voltage-dependent block of anthrax toxin channels in planar phospholipid bilayer membranes by symmetric tetraalkylammonium ions. Single-channel analysis, The Journal of General Physiology, vol.96, issue.5, pp.921-942, 1990. ,
DOI : 10.1085/jgp.96.5.921
URL : http://jgp.rupress.org/content/jgp/96/5/921.full.pdf
Anthrax Toxin Protective Antigen: Inhibition of Channel Function by Chloroquine and Related Compounds and Study of Binding Kinetics Using the Current Noise Analysis, Biophysical Journal, vol.88, issue.3, pp.1715-1724, 2005. ,
DOI : 10.1529/biophysj.104.050336
Preventing Voltage-dependent Gating of Anthrax Toxin Channels Using Engineered Disulfides, The Journal of General Physiology, vol.22, issue.3, pp.351-360, 2008. ,
DOI : 10.1529/biophysj.104.050864
URL : http://jgp.rupress.org/content/jgp/132/3/351.full.pdf
Structure and function of pore-forming beta-barrels from bacteria, J Mol Microbiol Biotechnol, vol.4, pp.1-10, 2002. ,
Mechanism of C2-toxin Inhibition by Fluphenazine and Related Compounds: Investigation of their Binding Kinetics to the C2II-channel using the Current Noise Analysis, Journal of Molecular Biology, vol.333, issue.3, pp.527-540, 2003. ,
DOI : 10.1016/j.jmb.2003.08.044
Inhibition of Anthrax Protective Antigen Outside and Inside the Cell, Antimicrobial Agents and Chemotherapy, vol.51, issue.1, pp.245-251, 2007. ,
DOI : 10.1128/AAC.00983-06
URL : http://aac.asm.org/content/51/1/245.full.pdf
Differential requirement for the translocation of clostridial binary toxins: Iota toxin requires a membrane potential gradient, FEBS Letters, vol.281, issue.7, pp.1287-1296, 2007. ,
DOI : 10.1074/jbc.M600477200
Clostridium perfringens Iota Toxin: Binding Studies and Characterization of Cell Surface Receptor by Fluorescence-Activated Cytometry, Infection and Immunity, vol.68, issue.6, pp.3475-3484, 2000. ,
DOI : 10.1128/IAI.68.6.3475-3484.2000
URL : http://iai.asm.org/content/68/6/3475.full.pdf
Membrane translocation by anthrax toxin, Molecular Aspects of Medicine, vol.30, issue.6, pp.413-422, 2009. ,
DOI : 10.1016/j.mam.2009.06.003
URL : http://europepmc.org/articles/pmc2783560?pdf=render
The unfolding story of anthrax toxin translocation, Molecular Microbiology, vol.455, issue.3, p.21443527, 2011. ,
DOI : 10.1038/nature07335
URL : http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2958.2011.07614.x/pdf
Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor, Science, vol.280, issue.5364, pp.734-737, 1998. ,
DOI : 10.1126/science.280.5364.734
Anthrax Lethal Factor Cleaves the N-Terminus of MAPKKs and Induces Tyrosine/Threonine Phosphorylation of MAPKs in Cultured Macrophages, Biochemical and Biophysical Research Communications, vol.248, issue.3, pp.706-711, 1998. ,
DOI : 10.1006/bbrc.1998.9040
The anthrax lethal factor and its MAPK kinase-specific metalloprotease activity, Molecular Aspects of Medicine, vol.30, issue.6, pp.431-438, 2009. ,
DOI : 10.1016/j.mam.2009.07.006
Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells., Proceedings of the National Academy of Sciences, vol.79, issue.10, pp.3162-3166, 1982. ,
DOI : 10.1073/pnas.79.10.3162
URL : http://www.pnas.org/content/79/10/3162.full.pdf
Bacillus anthracis calmodulin-dependent adenylate cyclase: chemical and enzymatic properties and interactions with eukaryotic cells, Adv Cyclic Nucleotide Protein Phosphorylation Res, vol.17, pp.189-198, 1984. ,
Anthrax Biosensor, Protective Antigen Ion Channel Asymmetric Blockade, Journal of Biological Chemistry, vol.266, issue.40, pp.34056-34062, 2005. ,
DOI : 10.1038/n35101998
URL : http://www.jbc.org/content/280/40/34056.full.pdf
Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers, Nature Structural & Molecular Biology, vol.276, issue.11, pp.1383-1390, 2010. ,
DOI : 10.1021/bi015860m
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133606
Role of the Protective Antigen Octamer in the Molecular Mechanism of Anthrax Lethal Toxin Stabilization in Plasma, Journal of Molecular Biology, vol.399, issue.5, pp.741-758, 2010. ,
DOI : 10.1016/j.jmb.2010.04.041
A Phenylalanine Clamp Catalyzes Protein Translocation Through the Anthrax Toxin Pore, Science, vol.309, issue.5735, pp.777-781, 2005. ,
DOI : 10.1126/science.1113380
URL : http://europepmc.org/articles/pmc1815389?pdf=render
C2 Toxin, Journal of Biological Chemistry, vol.100, issue.7, pp.3904-3914, 2008. ,
DOI : 10.1021/bi051830y
Symmetry Complementarity-Guided Design of Anthrax Toxin Inhibitors Based on ??-Cyclodextrin: Synthesis and Relative Activities of Face-Selective Functionalized Polycationic Clusters, ChemMedChem, vol.61, issue.1, pp.181-192, 2011. ,
DOI : 10.1016/j.bmc.2005.07.054
Tuning the Cavity of Cyclodextrins: Altered Sugar Adaptors in Protein Pores, Journal of the American Chemical Society, vol.133, issue.6, p.21244029, 2011. ,
DOI : 10.1021/ja1100867
Evidence that Arg-295, Glu-378, and Glu-380 are active-site residues of the ADP-ribosyltransferase activity of iota toxin, FEBS Letters, vol.29, issue.2-3, pp.191-194, 1996. ,
DOI : 10.1016/0041-0101(91)90076-4
URL : http://onlinelibrary.wiley.com/doi/10.1016/0014-5793(96)01035-6/pdf
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4, Nature, vol.244, issue.5259, pp.680-685, 1970. ,
DOI : 10.1101/SQB.1963.028.01.053
Formation of Bimolecular Membranes from Lipid Monolayers and a Study of Their Electrical Properties, Proceedings of the National Academy of Sciences, vol.69, issue.12, pp.3561-3566, 1972. ,
DOI : 10.1073/pnas.69.12.3561
URL : http://www.pnas.org/content/69/12/3561.full.pdf
Protonation dynamics of the alpha-toxin ion channel from spectral analysis of pH-dependent current fluctuations, Biophysical Journal, vol.69, issue.1, pp.94-105, 1995. ,
DOI : 10.1016/S0006-3495(95)79879-4
Data transformations for improved display and fitting of single-channel dwell time histograms, Biophysical Journal, vol.52, issue.6, pp.1047-1054, 1987. ,
DOI : 10.1016/S0006-3495(87)83298-8
URL : https://doi.org/10.1016/s0006-3495(87)83298-8