J. Sakurai, Toxins of Clostridium perfringens, Rev Med Microbiol, vol.6, pp.175-185, 1995.
DOI : 10.3109/15569549709016456

J. Goldstein, W. Morris, C. Loidl, C. Tironi-farinatti, and B. Mcclane, Clostridium perfringens Epsilon Toxin Increases the Small Intestinal Permeability in Mice and Rats, PLoS ONE, vol.29, issue.9, p.7065, 2009.
DOI : 10.1371/journal.pone.0007065.t002

URL : https://doi.org/10.1371/journal.pone.0007065

F. Uzal, Diagnosis of Clostridium perfringens intestinal infections in sheep and goats, Anaerobe, vol.10, issue.2, pp.135-143, 2004.
DOI : 10.1016/j.anaerobe.2003.08.005

URL : http://journals.sagepub.com/doi/pdf/10.1177/104063870802000301

J. Finnie, Neurological disorders produced by Clostridium perfringens type D epsilon toxin, Anaerobe, vol.10, issue.2, pp.145-150, 2004.
DOI : 10.1016/j.anaerobe.2003.08.003

A. Cole, M. Gibert, M. Popoff, D. Moss, and R. Titball, Clostridium perfringens ??-toxin shows structural similarity to the pore-forming toxin aerolysin, Nature Structural & Molecular Biology, vol.25, issue.8, pp.797-798, 2004.
DOI : 10.1046/j.1365-2958.1997.4541820.x

J. Melton, M. Parker, J. Rossjohn, J. Buckley, and R. Tweten, Alpha Toxin, Journal of Biological Chemistry, vol.56, issue.14, pp.14315-14322, 2004.
DOI : 10.1021/bi0155394

J. Melton, R. Tweten, M. Alouf, and . Popoff, Clostridium septicum pore-forming ??-toxin, The Comprehensive Sourcebook of Bacterial Protein Toxins, pp.623-630, 2006.
DOI : 10.1016/B978-012088445-2/50039-1

L. Petit, M. Gibert, D. Gillet, C. Laurent-winter, and P. Boquet, Clostridium perfringens epsilon-toxin acts on MDCK cells by forming a large membrane complex., Journal of Bacteriology, vol.179, issue.20, pp.6480-6487, 1997.
DOI : 10.1128/jb.179.20.6480-6487.1997

URL : http://jb.asm.org/content/179/20/6480.full.pdf

L. Petit, E. Maier, M. Gibert, M. Popoff, and R. Benz, Epsilon Toxin Induces a Rapid Change of Cell Membrane Permeability to Ions and Forms Channels in Artificial Lipid Bilayers, Journal of Biological Chemistry, vol.58, issue.19, pp.15736-15740, 2001.
DOI : 10.1016/S0092-8674(00)81564-0

S. Miyata, J. Minami, E. Tamai, O. Matsushita, and S. Shimamoto, ??-Toxin Forms a Heptameric Pore within the Detergent-insoluble Microdomains of Madin-Darby Canine Kidney Cells and Rat Synaptosomes, Journal of Biological Chemistry, vol.335, issue.42, pp.39463-39468, 2002.
DOI : 10.1111/j.1574-695X.2001.tb00503.x

C. Chassin, M. Bens, J. De-barry, R. Courjaret, and J. Bossu, Pore-forming epsilon toxin causes membrane permeabilization and rapid ATP depletion-mediated cell death in renal collecting duct cells, American Journal of Physiology-Renal Physiology, vol.293, issue.3, pp.927-937, 2007.
DOI : 10.1053/jcpa.2001.0514

URL : http://ajprenal.physiology.org/content/ajprenal/293/3/F927.full.pdf

O. Knapp, E. Maier, R. Benz, B. Geny, and M. Popoff, Identification of the channel-forming domain of Clostridium perfringens Epsilon-toxin (ETX), Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1788, issue.12, pp.2584-2593, 2009.
DOI : 10.1016/j.bbamem.2009.09.020

S. Miyata, O. Matsushita, J. Minami, S. Katayama, and S. Shimamoto, ??-Toxin in the Synaptosomal Membrane, Journal of Biological Chemistry, vol.11, issue.17, pp.13778-13783, 2001.
DOI : 10.1074/jbc.274.51.36722

S. Shimamoto, E. Tamai, O. Matsushita, J. Minami, and A. Okabe, Epsilon-Toxin to Detergent-Resistant Membranes of Madin-Darby Canine Kidney Cells, Microbiology and Immunology, vol.169, issue.3, pp.245-253, 2005.
DOI : 10.1006/exnr.2001.7652

F. Uzal, W. Kelly, W. Morris, J. Bermudez, and M. Baiso-'n, Type D Enterotoxemia in Sheep, Journal of Veterinary Diagnostic Investigation, vol.31, issue.5, pp.403-411, 2004.
DOI : 10.1046/j.1472-765X.1997.00247.x

URL : http://journals.sagepub.com/doi/pdf/10.1177/030098589803500207

M. Fernandez-miyakawa, S. Sayeed, D. Fisher, R. Poon, and V. Adams, Development and Application of an Oral Challenge Mouse Model for Studying Clostridium perfringens Type D Infection, Infection and Immunity, vol.75, issue.9, pp.4282-4288, 2007.
DOI : 10.1128/IAI.00562-07

URL : http://iai.asm.org/content/75/9/4282.full.pdf

J. Finnie, Histopathological changes in the brain of mice given Clostridium perfringens type D epsilon toxin, Journal of Comparative Pathology, vol.94, issue.3, pp.363-370, 1984.
DOI : 10.1016/0021-9975(84)90024-0

O. Miyamoto, J. Minami, T. Toyoshima, T. Nakamura, and T. Masada, Neurotoxicity of Clostridium perfringens epsilon-toxin for the rat hipocampus via glutamanergic system, Infect. Immun, vol.66, pp.2501-2508, 1998.

O. Miyamoto, K. Sumitami, T. Nakamura, S. Yamagani, and S. Miyatal, epsilon toxin causes excessive release of glutamate in the mouse hippocampus, FEMS Microbiology Letters, vol.31, issue.1, pp.109-113, 2000.
DOI : 10.1136/vr.143.17.472

M. Nagahama and J. Sakurai, Effect of drugs acting on the central nervous system on the lethality in mice of Clostridium perfringens epsilon toxin, Toxicon, vol.31, issue.4, pp.427-435, 1993.
DOI : 10.1016/0041-0101(93)90178-L

J. Finnie, P. Blumbergs, and J. Manavis, Neuronal Damage Produced in Rat Brains byClostridium perfringensType D Epsilon Toxin, Journal of Comparative Pathology, vol.120, issue.4, pp.415-420, 1999.
DOI : 10.1053/jcpa.1998.0289

C. Zhu, M. Ghabriel, P. Blumbergs, P. Reilly, and J. Manavis, Clostridium perfringens Prototoxin-Induced Alteration of Endothelial Barrier Antigen (EBA) Immunoreactivity at the Blood???Brain Barrier (BBB), Experimental Neurology, vol.169, issue.1, pp.72-82, 2001.
DOI : 10.1006/exnr.2001.7652

A. Soler-jover, J. Blasi, G. De-aranda, I. Navarro, P. Gibert et al., Effect of Epsilon Toxin???GFP on MDCK Cells and Renal Tubules In Vivo, Journal of Histochemistry & Cytochemistry, vol.9, issue.7, pp.931-942, 2004.
DOI : 10.1006/exnr.2001.7652

URL : http://journals.sagepub.com/doi/pdf/10.1369/jhc.4A6254.2004

A. Soler-jover, J. Dorca, M. Popoff, M. Gibert, and J. Saura, Distribution of Clostridium perfringens epsilon toxin in the brains of acutely intoxicated mice and its effect upon glial cells, Toxicon, vol.50, issue.4, pp.530-540, 2007.
DOI : 10.1016/j.toxicon.2007.04.025

M. Nagahama and J. Sakurai, High-affinity binding of Clostridium perfringens epsilon-toxin to rat brain, Infect Immun, vol.60, pp.1237-1240, 1992.

J. Dorca-arévalo, A. Soler-jover, M. Gibert, M. Popoff, and M. Martín-satué, Binding of ??-toxin from Clostridium perfringens in the nervous system, Veterinary Microbiology, vol.131, issue.1-2, pp.14-25, 2008.
DOI : 10.1016/j.vetmic.2008.02.015

S. Palay and V. Chan-palay, Cerebellar cortex cytology and organization, 1974.

J. Dupont, E. Fourcaudot, H. Beekenkamp, B. Poulain, and J. Bossu, Synaptic organization of the mouse cerebellar cortex in organotypic slice cultures, The Cerebellum, vol.5, issue.4, pp.243-256, 2006.
DOI : 10.1080/14734220600905317

E. Lonchamp, J. Dupont, F. Doussau, H. Shin, and B. Poulain, Deletion of Cav2.1(????1A) subunit of Ca2+-channels impairs synaptic GABA and glutamate release in the mouse cerebellar cortex in cultured slices, European Journal of Neuroscience, vol.22, issue.12, pp.2293-307, 2009.
DOI : 10.1113/jphysiol.1995.sp020535

R. Adamson, J. Ly, M. Fernandez-miyakawa, S. Ochi, and J. Sakurai, Clostridium perfringens Epsilon-Toxin Increases Permeability of Single Perfused Microvessels of Rat Mesentery, Infection and Immunity, vol.73, issue.8, pp.4879-4887, 2005.
DOI : 10.1128/IAI.73.8.4879-4887.2005

URL : http://iai.asm.org/content/73/8/4879.full.pdf

J. Dietschy and S. Turley, Cholesterol metabolism in the central nervous system during early development and in the mature animal, Journal of Lipid Research, vol.44, issue.8, pp.1375-1397, 2004.
DOI : 10.1194/jlr.R300007-JLR200

D. Payne, E. Williamson, H. Havard, N. Modi, and J. Brown, type D epsilon toxin, FEMS Microbiology Letters, vol.29, issue.(No. 2), pp.161-167, 1994.
DOI : 10.1016/0005-2795(73)90300-0

L. Petit, M. Gibert, A. Gourch, M. Bens, and A. Vandewalle, Clostridium perfringens epsilon toxin rapidly decreases membrane barrier permeability of polarized MDCK cells, Cellular Microbiology, vol.61, issue.4967, pp.155-164, 2003.
DOI : 10.1006/exnr.2001.7652

URL : http://onlinelibrary.wiley.com/doi/10.1046/j.1462-5822.2003.00262.x/pdf

D. Buxton, In-Vitro Effects of Clostridium Welchii Type-D Epsilon Toxin on Guinea-Pig, Mouse, Rabbit and Sheep Cells, Journal of Medical Microbiology, vol.11, issue.3, pp.299-302, 1978.
DOI : 10.1099/00222615-11-3-299

E. Ottico, A. Prinetti, S. Prioni, C. Giannotta, and L. Basso, Dynamics of membrane lipid domains in neuronal cells differentiated in culture, Journal of Lipid Research, vol.455, issue.11, pp.2142-2151, 2003.
DOI : 10.1016/0009-3084(94)02304-2

D. Gill, Bacterial Toxins: lethal amounts, pp.127-135, 1987.

M. Popoff, Purification and characterization of Clostridium sordellii lethal toxin and cross-reactivity with Clostridium difficile cytotoxin, Infect Immun, vol.55, pp.35-43, 1987.

B. Gä-hwiler, Organotypic monolayer cultures of nervous tissue, Journal of Neuroscience Methods, vol.4, issue.4, pp.329-342, 1981.
DOI : 10.1016/0165-0270(81)90003-0

P. Munro, H. Kojima, J. Dupont, J. Bossu, and B. Poulain, High Sensitivity of Mouse Neuronal Cells to Tetanus Toxin Requires a GPI-Anchored Protein, Biochemical and Biophysical Research Communications, vol.289, issue.2, pp.623-629, 2001.
DOI : 10.1006/bbrc.2001.6031

C. Ribaut-barassin, J. Dupont, A. Haeberlé, G. Bombarde, and G. Huber, Alzheimer's disease proteins in cerebellar and hippocampal synapses during postnatal development and aging of the rat, Neuroscience, vol.120, issue.2, pp.405-423, 2003.
DOI : 10.1016/S0306-4522(03)00332-4

Q. Li, A. Lau, T. Morris, L. Guo, and C. Fordyce, A Syntaxin 1, G??o, and N-Type Calcium Channel Complex at a Presynaptic Nerve Terminal: Analysis by Quantitative Immunocolocalization, Journal of Neuroscience, vol.24, issue.16, pp.4070-4081, 2004.
DOI : 10.1523/JNEUROSCI.0346-04.2004

URL : http://www.jneurosci.org/content/jneuro/24/16/4070.full.pdf

J. De-barry, A. Janoshazi, J. Dupont, O. Procksch, and S. Chasserot-golaz, Functional Implication of Neuronal Calcium Sensor-1 and Phosphoinositol 4-Kinase-?? Interaction in Regulated Exocytosis of PC12 Cells, Journal of Biological Chemistry, vol.171, issue.26, pp.18098-18111, 2006.
DOI : 10.1074/jbc.M413090200

J. Chapman and M. Zhou, Microplate-based fluorometric methods for the enzymatic determination of l-glutamate: application in measuring l-glutamate in food samples, Analytica Chimica Acta, vol.402, issue.1-2, pp.47-52, 1999.
DOI : 10.1016/S0003-2670(99)00533-4

C. Thompson and F. Stephenson, GABAA Receptor Subtypes Expressed in Cerebellar Granule Cells: A Developmental Study, Journal of Neurochemistry, vol.59, issue.5, pp.2037-2044, 1994.
DOI : 10.1016/B978-0-12-185254-2.50011-5

M. Weiser, E. Bueno, C. Sekirnjak, M. Martone, and H. Baker, The potassium channel subunit KV3.1b is localized to somatic and axonal membranes of specific populations of CNS neurons, The Journal of Neuroscience, vol.15, issue.6, pp.4298-4314, 1995.
DOI : 10.1523/JNEUROSCI.15-06-04298.1995

J. Barski, J. Hartmann, C. Rose, F. Hoebeek, and K. Morl, Calbindin in Cerebellar Purkinje Cells Is a Critical Determinant of the Precision of Motor Coordination, The Journal of Neuroscience, vol.23, issue.8, pp.3469-3477, 2003.
DOI : 10.1523/JNEUROSCI.23-08-03469.2003

M. Fox and J. Sanes, Synaptotagmin I and II are present in distinct subsets of central synapses, The Journal of Comparative Neurology, vol.252, issue.2, pp.280-296, 2007.
DOI : 10.1002/cne.21381

T. Kadota, M. Fujita, and K. Kadota, Immunocytochemical Localization of Synaptophysin on the Smooth-Surfaced Tubular Membranes Present in Nerve Terminal and Preterminal Areas in the Rat Cerebellar Cortex., Archives of Histology and Cytology, vol.54, issue.5, pp.519-525, 1991.
DOI : 10.1679/aohc.54.519

O. Castejón, L. Fuller, and M. Dailey, Localization of synapsin-I and PSD-95 in developing postnatal rat cerebellar cortex, Developmental Brain Research, vol.151, issue.1-2, pp.25-32, 2004.
DOI : 10.1016/j.devbrainres.2004.03.019

G. Huber and A. Matus, Differences in the cellular distributions of two microtubule-associated proteins, MAP1 and MAP2, in rat brain, The Journal of Neuroscience, vol.4, issue.1, pp.151-160, 1984.
DOI : 10.1523/JNEUROSCI.04-01-00151.1984

E. Fuchs and K. Weber, Intermediate Filaments: Structure, Dynamics, Function and Disease, Annual Review of Biochemistry, vol.63, issue.1, pp.345-382, 1994.
DOI : 10.1146/annurev.bi.63.070194.002021

T. Imura, H. Kornblum, and M. Sofroniew, The Predominant Neural Stem Cell Isolated from Postnatal and Adult Forebrain But Not Early Embryonic Forebrain Expresses GFAP, The Journal of Neuroscience, vol.23, issue.7, pp.2824-2832, 2003.
DOI : 10.1523/JNEUROSCI.23-07-02824.2003

B. Trapp, L. Bernier, S. Andrews, and D. Colman, Cellular and Subcellular Distribution of 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase and Its mRNA in the Rat Central Nervous System, Journal of Neurochemistry, vol.37, issue.3, pp.859-868, 1988.
DOI : 10.1002/ana.410230108