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Proteomic analysis of plasma extracellular vesicles reveals mitochondrial stress upon HTLV-1 infection

Abstract : Extracellular vesicles (EVs) can participate in intercellular communication and pathogenesis. EVs contain many cargos, including proteins, and the composition of EVs differs between cell-types and activation levels. Thus, plasma EVs can be used as a biomarker of systemic response to infection and/ or disease progression. In this study, we aimed at describing alterations in the protein content of plasma EVs upon infection with the human T-lymphotropic retrovirus type 1 (HTLV-1). HTLV-1 is the etiological agent of a lymphoproliferative disease (ATL) and a series of inflammatory diseases, including a neurodegenerative inflammatory disease (HAM/TSP). We found that plasma EVs are more abundant and smaller in HTLV-1 asymptomatic carriers or HAM/TSP patients when compared to uninfected healthy donors. Moreover, EVs from HTLV-1 infected donors contain markers of metabolic and mitochondrial stress.
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Submitted on : Tuesday, March 27, 2018 - 4:09:09 PM
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Patricia Jeannin, Thibault Chaze, Quentin Gianetto, Mariette Matondo, Olivier Gout, et al.. Proteomic analysis of plasma extracellular vesicles reveals mitochondrial stress upon HTLV-1 infection. Scientific Reports, Nature Publishing Group, 2018, 8, pp.5170 - 5170. ⟨10.1038/s41598-018-23505-0⟩. ⟨pasteur-01744767⟩

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