Dengue nonstructural protein 1 antigen in the urine as a rapid and convenient diagnostic test during the febrile stage in patients with dengue infection.

Ampaiwan Chuansumrit (1) , Wathanee Chaiyaratana (2) , Kanchana Tangnararatchakit (1) , Sutee Yoksan (3) , Marie Flamand (4) , Anavaj Sakuntabhai (5, 6)

1 Department of Pediatrics, Faculty of Medicine
2 Ramathibodi Hospital
3 Center for Vaccine Development
4 Génétique Moléculaire des Bunyavirus
5 CVVD - Center of Excellence for Vectors and Vector-Borne Diseases
6 Pathogénie Virale

A total of 136 matched serum and urine samples obtained from 55 patients with dengue infection and 30 other febrile illnesses were assayed for dengue nonstructural protein 1 (NS1) antigen. The urine NS1 ELISA was positive in patients with dengue fever (68.4%) and dengue hemorrhagic fever (63.9%), whereas the strip method showed a lower positive rate.

Keywords: Dengue nonstructural protein 1 antigen; NS1; urine; dengue infection; early dengue diagnosis

Domains: Life Sciences [q-bio]; Microbiology and Parasitology

Ampaiwan Chuansumrit, Wathanee Chaiyaratana, Kanchana Tangnararatchakit, Sutee Yoksan, Marie Flamand, et al.. Dengue nonstructural protein 1 antigen in the urine as a rapid and convenient diagnostic test during the febrile stage in patients with dengue infection.. Diagnostic Microbiology and Infectious Disease, 2011, 71 (4), pp.467-469. ⟨10.1016/j.diagmicrobio.2011.08.020⟩. ⟨pasteur-01741101⟩