Combating Global Antibiotic Resistance: Emerging One Health Concerns in Lower- and Middle-Income Countries

Maya Nadimpalli (1) , Elisabeth Delarocque-Astagneau (1) , David Love (2) , Lance Price , Bich-Tram Huynh (3) , Jean-Marc Collard (4) , Kruy Sun Lay (5) , Laurence Borand (6) , Awa Ndir (7) , Timothy Walsh (8) , Didier Guillemot (1) , Agathe de Lauzanne , Alexandra Kerleguer , Arnaud Tarantola (5) , Patrice Piola (9) , Thida Chon , Siyin Lach , Veronique Ngo , Sok Touch (10) , Zo Zafitsara Andrianirina , Muriel Vray (11) , Vincent Richard (9) , Abdoulaye Abdou , Raymond Bercion (12) , Amy Gassama Sow (7) , Jean Baptiste Diouf (13) , Pape Samba Dieye , Balla Sy , Bouya Ndao , Maud Séguy (14) , Laurence Watier (3) , Armiya Youssouf Abdou

1 B2PHI - Biostatistique, Biomathématique, Pharmacoépidémiologie et Maladies Infectieuses
2 Johns Hopkins Bloomberg School of Public Health [Baltimore]
3 Pharmacoepidemiologie et évaluation de l'impact des produits de santé sur les populations
4 IPM - Unité de Bactériologie Expérimentale [Antananarivo, Madagascar]
5 Institut Pasteur du Cambodge
6 Unité d'Épidémiologie et de Santé Publique [Phnom Penh]
7 Institut Pasteur de Dakar
8 UQAM - Université du Québec à Montréal = University of Québec in Montréal
9 IPM - Unité d'Epidémiologie [Antananarivo, Madagascar]
10 CDC MOH - Communicable Disease Department [Phnom Penh]
11 Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology
12 Institut Pasteur de Bangui
13 IDEFI-N-Reflexpro
14 ECOTROP - Fonctionnement, évolution et mécanismes régulateurs des écosystèmes forestiers

Antibiotic misuse in lower- and middle-income countries (LMICs) contributes to the development of antibiotic resistance that can disseminate globally. Strategies specific to LMICs that seek to reduce antibiotic misuse by humans, but simultaneously improve antibiotic access, have been proposed. However, most approaches to date have not considered the growing impact of animal and environmental reservoirs of antibiotic resistance, which threaten to exacerbate the antibiotic resistance crisis in LMICs. In particular, current strategies do not prioritize the impacts of increased antibiotic use for terrestrial food-animal and aquaculture production, inadequate food safety, and widespread environmental pollution. Here, we propose new approaches that address emerging, One Health challenges.

Domains: Life Sciences [q-bio]; Human health and pathology; Infectious diseases

Maya Nadimpalli, Elisabeth Delarocque-Astagneau, David Love, Lance Price, Bich-Tram Huynh, et al.. Combating Global Antibiotic Resistance: Emerging One Health Concerns in Lower- and Middle-Income Countries. Clinical Infectious Diseases, 2018, 66 (6), pp.963 - 969. ⟨10.1093/cid/cix879⟩. ⟨pasteur-01739401⟩