Proteinuria during dengue fever in children

Anne-Claire Andries (1) , Veasna Duong (1) , Julien Cappelle (2, 3) , Sivuth Ong (1) , Alexandra Kerleguer (4) , Sowath Ly (2) , Arnaud Tarantola (2) , Paul Horwood (1) , Anavaj Sakuntabhai (5) , Philippe Dussart (1) , Philippe Buchy (1, 6)

1 Unité de Virologie / Virology Unit [Phnom Penh]
2 Unité d'Épidémiologie et de Santé Publique [Phnom Penh]
3 UPR AGIRs - Animal et gestion intégrée des risques
4 Institut Pasteur du Cambodge
5 Génétique fonctionnelle des Maladies infectieuses - Functional Genetics of Infectious Diseases
6 GlaxoSmithKline

OBJECTIVES: This study aimed to investigate proteinuria occurring during dengue disease in children and assess if measurement of this parameter can help physicians in the clinical management of patients. METHODS: Proteinuria was assessed by dipstick and quantified by urine protein:creatinine ratio (UPCR) in samples from patients hospitalized with a confirmed dengue infection and in healthy controls. RESULTS: The dipstick tested positive in 42.9% of the patients presenting at hospital with dengue versus 20.0% in healthy controls. UPCR increased during the critical phase of the disease; peaking one week after fever onset then decreasing as the patients recovered. Patients with warnings signs or severe dengue were more likely to present with proteinuria detected by UPCR at the time of hospital admission compared to patients without warning signs. The sensitivity of this marker, however, was limited as only 16.1% of the patients with warning signs had proteinuria. CONCLUSIONS: Urine dipstick and UPCR do not seem to be very valuable for the triage of the patients at the time of the initial consultation but the observation of a decrease of the UPCR during the course of the illness appears to indicate an evolution towards recovery.

Keywords: Dengue; UPCR; dipstick; proteinuria; urine; urine electrophoresis

Domains: Life Sciences [q-bio]; Human health and pathology; Infectious diseases

Anne-Claire Andries, Veasna Duong, Julien Cappelle, Sivuth Ong, Alexandra Kerleguer, et al.. Proteinuria during dengue fever in children. International Journal of Infectious Diseases, 2017, 55, pp.38 - 44. ⟨10.1016/j.ijid.2016.12.022⟩. ⟨pasteur-01739353⟩