A. Waldorf, K. M. Mcadams, and R. M. , Influence of infection during pregnancy on fetal development, Reproduction, vol.7, issue.3, pp.151-162, 2013.
DOI : 10.1371/journal.ppat.1002005

A. Q. Araujo, M. T. Silva, and A. P. Araujo, Zika virus-associated neurological disorders: a review, Brain, vol.109, issue.1, pp.2122-2130, 2016.
DOI : 10.1038/cr.2016.58

URL : https://academic.oup.com/brain/article-pdf/139/8/2122/17944841/aww158.pdf

B. I. Bae, D. Jayaraman, W. , and C. A. , Genetic Changes Shaping the Human Brain, Developmental Cell, vol.32, issue.4, pp.423-434, 2015.
DOI : 10.1016/j.devcel.2015.01.035

N. J. Barrows, R. K. Campos, S. T. Powell, K. R. Prasanth, G. Schott-lerner et al., A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection, Cell Host & Microbe, vol.20, issue.2, pp.259-270, 2016.
DOI : 10.1016/j.chom.2016.07.004

S. M. Belgnaoui, S. Paz, and J. Hiscott, Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter, Current Opinion in Immunology, vol.23, issue.5, pp.564-572, 2011.
DOI : 10.1016/j.coi.2011.08.001

T. M. Bell, E. J. Field, and H. K. Narang, Zika virus infection of the central nervous system of mice, Archiv f???r die gesamte Virusforschung, vol.20, issue.2-3, pp.183-193, 1971.
DOI : 10.1007/BF01249709

P. Brasil, P. C. Sequeira, A. D. Freitas, H. E. Zogbi, G. A. Calvet et al., Guillain-Barr?? syndrome associated with Zika virus infection, The Lancet, vol.387, issue.10026, p.1482, 2016.
DOI : 10.1016/S0140-6736(16)30058-7

N. Broutet, F. Krauer, M. Riesen, A. Khalakdina, M. Almiron et al., Zika Virus as a Cause of Neurologic Disorders, New England Journal of Medicine, vol.374, issue.16, pp.1506-1509, 2016.
DOI : 10.1056/NEJMp1602708

G. J. Burton and A. L. Fowden, The placenta: a multifaceted, transient organ, Philosophical Transactions of the Royal Society B: Biological Sciences, vol.12, issue.6, 2015.
DOI : 10.1093/humupd/dml016

L. Conti, C. , and E. , Neural stem cell systems: physiological players or in vitro entities?, Nature Reviews Neuroscience, vol.115, issue.3, pp.176-187, 2010.
DOI : 10.4161/cc.7.6.5550

N. A. Dalrymple, V. Cimica, and E. R. Mackow, Dengue Virus NS Proteins Inhibit RIG-I/MAVS Signaling by Blocking TBK1/IRF3 Phosphorylation: Dengue Virus Serotype 1 NS4A Is a Unique Interferon-Regulating Virulence Determinant, mBio, vol.6, issue.3, pp.553-568, 2015.
DOI : 10.1128/mBio.00553-15

J. Dang, S. K. Tiwari, G. Lichinchi, Y. Qin, V. S. Patil et al., Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3, Cell Stem Cell, vol.19, issue.2, pp.258-265, 2016.
DOI : 10.1016/j.stem.2016.04.014

S. Darmanis, S. A. Sloan, Y. Zhang, M. Enge, C. Caneda et al., A survey of human brain transcriptome diversity at the single cell level, Proc. Natl. Acad. Sci. USA, pp.7285-7290, 2015.
DOI : 10.1002/dneu.20853

B. De-paula-freitas, J. R. De-oliveira-dias, J. Prazeres, G. A. Sacramento, A. I. Ko et al., Ocular Findings in Infants With Microcephaly Associated With Presumed Zika Virus Congenital Infection in Salvador, Brazil, JAMA Ophthalmology, vol.134, issue.5, pp.529-535, 2016.
DOI : 10.1001/jamaophthalmol.2016.0267

A. L. Diaz and J. G. Gleeson, The Molecular and Genetic Mechanisms of Neocortex Development, Clinics in Perinatology, vol.36, issue.3, pp.503-512, 2009.
DOI : 10.1016/j.clp.2009.06.008

R. Edri, Y. Yaffe, M. J. Ziller, N. Mutukula, R. Volkman et al., Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors, Nature Communications, vol.491, issue.1, p.6500, 2015.
DOI : 10.1038/nbt.1529

Y. Elkabetz, G. Panagiotakos, A. Shamy, G. Socci, N. D. Tabar et al., Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage, Genes & Development, vol.22, issue.2, pp.152-165, 2008.
DOI : 10.1101/gad.1616208

L. Eyer, R. Nencka, I. Huvarová, M. Palus, J. Alves et al., Nucleoside Inhibitors of Zika Virus, Journal of Infectious Diseases, vol.40, issue.5, pp.707-711, 2016.
DOI : 10.1021/jm030424e

M. Farlik, B. Rapp, I. Marie, D. E. Levy, A. M. Jamieson et al., Contribution of a TANK-Binding Kinase 1-Interferon (IFN) Regulatory Factor 7 Pathway to IFN-??-Induced Gene Expression, Molecular and Cellular Biology, vol.32, issue.6, pp.1032-1043, 2012.
DOI : 10.1128/MCB.06021-11

J. D. Fine and K. A. Arndt, The TORCH syndrome: A clinical review, Journal of the American Academy of Dermatology, vol.12, issue.4, pp.697-706, 1985.
DOI : 10.1016/S0190-9622(85)70095-3

F. H. Gage, T. , and S. , Neural Stem Cells: Generating and Regenerating the Brain, Neuron, vol.80, issue.3, pp.588-601, 2013.
DOI : 10.1016/j.neuron.2013.10.037

URL : https://doi.org/10.1016/j.neuron.2013.10.037

P. P. Garcez, E. C. Loiola, R. Madeiro-da-costa, L. M. Higa, P. Trindade et al., Zika virus impairs growth in human neurospheres and brain organoids, Science, vol.31, issue.4, pp.816-818, 2016.
DOI : 10.4269/ajtmh.1982.31.830

R. Hamel, O. Dejarnac, S. Wichit, P. Ekchariyawat, A. Neyret et al., ABSTRACT, Journal of Virology, vol.89, issue.17, pp.8880-8896, 2015.
DOI : 10.1128/JVI.00354-15

N. W. Hanners, J. L. Eitson, N. Usui, R. B. Richardson, E. M. Wexler et al., Western Zika Virus in Human Fetal Neural Progenitors Persists Long Term with Partial Cytopathic and Limited Immunogenic Effects, Cell Reports, vol.15, issue.11, pp.2315-2322, 2016.
DOI : 10.1016/j.celrep.2016.05.075

Z. He, X. Zhu, W. Wen, J. Yuan, Y. Hu et al., ABSTRACT, Journal of Virology, vol.90, issue.16, pp.7219-7230, 2016.
DOI : 10.1128/JVI.00221-16

E. Helgason, Q. T. Phung, and E. C. Dueber, Recent insights into the complexity of Tank-binding kinase 1 signaling networks: The emerging role of cellular localization in the activation and substrate specificity of TBK1, FEBS Letters, vol.201, issue.8, pp.1230-1237, 2013.
DOI : 10.1677/JOE-08-0276

H. J. Kang, Y. I. Kawasawa, F. Cheng, Y. Zhu, X. Xu et al., Spatio-temporal transcriptome of the human brain, Nature, vol.88, issue.7370, pp.483-489, 2011.
DOI : 10.1016/j.ygeno.2006.03.021

P. Koch, T. Opitz, J. A. Steinbeck, J. Ladewig, and O. Br?-ustle, A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration, Proc. Natl. Acad. Sci. USA, pp.3225-3230, 2009.
DOI : 10.1073/pnas.0509315102

R. Krumlauf, H. Marshall, M. Studer, S. Nonchev, M. H. Sham et al., Hox homeobox genes and regionalisation of the nervous system, Journal of Neurobiology, vol.341, issue.10, pp.1328-1340, 1993.
DOI : 10.1016/0168-9525(93)90203-T

H. M. Lazear, A. Lancaster, C. Wilkins, M. S. Suthar, A. Huang et al., IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling, PLoS Pathog, vol.9, 2013.

H. M. Lazear, J. Govero, A. M. Smith, D. J. Platt, E. Fernandez et al., A Mouse Model of Zika Virus Pathogenesis, Cell Host & Microbe, vol.19, issue.5, pp.720-730, 2016.
DOI : 10.1016/j.chom.2016.03.010

C. Li, D. Xu, Q. Ye, S. Hong, Y. Jiang et al., Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice, Cell Stem Cell, vol.19, issue.1, pp.120-126, 2016.
DOI : 10.1016/j.stem.2016.04.017

S. Liu, X. Cai, J. Wu, Q. Cong, X. Chen et al., Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation, Science, vol.14, issue.6, 2015.
DOI : 10.1101/gr.849004

J. H. Lui, D. V. Hansen, and A. R. Kriegstein, Development and Evolution of the Human Neocortex, Cell, vol.146, issue.1, pp.18-36, 2011.
DOI : 10.1016/j.cell.2011.06.030

M. Marín-padilla, The human brain intracerebral microvascular system: development and structure, Frontiers in Neuroanatomy, vol.6, p.38, 2012.
DOI : 10.3389/fnana.2012.00038

J. J. Miner, D. , and M. S. , Understanding How Zika Virus Enters and Infects Neural Target Cells, Cell Stem Cell, vol.18, issue.5, pp.559-560, 2016.
DOI : 10.1016/j.stem.2016.04.009

URL : https://doi.org/10.1016/j.stem.2016.04.009

K. Møllgå-rd, S. , and N. R. , THE DEVELOPMENT OF THE HUMAN BLOOD-BRAIN AND BLOOD-CSF BARRIERS, Neuropathology and Applied Neurobiology, vol.33, issue.4, pp.337-358, 1986.
DOI : 10.1002/cne.902040105

G. Mor, Placental Inflammatory Response to Zika Virus may Affect Fetal Brain Development, American Journal of Reproductive Immunology, vol.72, issue.Suppl 1, pp.421-422, 2016.
DOI : 10.1111/aji.12289

URL : http://onlinelibrary.wiley.com/doi/10.1111/aji.12505/pdf

N. Neu, J. Duchon, Z. , and P. , TORCH Infections, Clinics in Perinatology, vol.42, issue.1, pp.77-103, 2015.
DOI : 10.1016/j.clp.2014.11.001

Y. Ning, M. Wang, M. Deng, S. Shen, W. Liu et al., Viral suppression of innate immunity via spatial isolation of TBK1/IKK?? from mitochondrial antiviral platform, Journal of Molecular Cell Biology, vol.364, issue.4, pp.324-337, 2014.
DOI : 10.1056/NEJMoa1010095

T. J. Nowakowski, A. A. Pollen, D. Lullo, E. Sandoval-espinosa, C. Bershteyn et al., Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells, Cell Stem Cell, vol.18, issue.5, pp.591-596, 2016.
DOI : 10.1016/j.stem.2016.03.012

E. Oehler, L. Watrin, P. Larre, I. Leparc-goffart, S. Lastere et al., Zika virus infection complicated by Guillain-Barre syndrome?case report, French Polynesia, Euro Surveill, vol.19, 2013.
DOI : 10.2807/1560-7917.es2014.19.9.20720

M. Onorati, M. Binetti, L. Conti, S. Camnasio, G. Calabrese et al., Preservation of positional identity in fetus-derived neural stem (NS) cells from different mouse central nervous system compartments, Cellular and Molecular Life Sciences, vol.38, issue.Suppl 1, pp.1769-1783, 2011.
DOI : 10.1016/j.mcn.2008.02.014

M. Onorati, V. Castiglioni, D. Biasci, E. Cesana, R. Menon et al., Molecular and functional definition of the developing human striatum, Nature Neuroscience, vol.124, issue.12, pp.1804-1815, 2014.
DOI : 10.1007/s12015-013-9441-8

S. Pattabhi, C. R. Wilkins, R. Dong, M. L. Knoll, J. Posakony et al., ABSTRACT, Journal of Virology, vol.90, issue.5, pp.2372-2387, 2016.
DOI : 10.1128/JVI.02202-15

S. Pillai, J. Nguyen, J. Johnson, E. Haura, D. Coppola et al., Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis, Nature Communications, vol.20, issue.1, 2015.
DOI : 10.1002/(SICI)1522-2683(19991201)20:18<3551::AID-ELPS3551>3.0.CO;2-2

X. Qian, H. N. Nguyen, M. M. Song, C. Hadiono, S. C. Ogden et al., Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure, Cell, vol.165, issue.5, pp.1238-1254, 2016.
DOI : 10.1016/j.cell.2016.04.032

URL : https://doi.org/10.1016/j.cell.2016.04.032

S. M. Reilly, S. Chiang, S. J. Decker, L. Chang, M. Uhm et al., An inhibitor of the protein kinases TBK1 and IKK-?? improves obesity-related metabolic dysfunctions in mice, Nature Medicine, vol.2005, issue.3, pp.313-321, 2013.
DOI : 10.1126/stke.2682005pe4

M. R. Roberts, K. Bittman, W. W. Li, R. French, B. Mitchell et al., The flathead mutation causes CNS-specific developmental abnormalities and apoptosis, J. Neurosci, vol.20, pp.2295-2306, 2000.

E. J. Rubin, M. F. Greene, and L. R. Baden, Zika Virus and Microcephaly, New England Journal of Medicine, vol.374, issue.10, pp.984-985, 2016.
DOI : 10.1056/NEJMe1601862

L. Schuler-faccini, E. M. Ribeiro, I. M. Feitosa, D. D. Horovitz, D. P. Cavalcanti et al., Possible Association Between Zika Virus Infection and Microcephaly ??? Brazil, 2015, MMWR. Morbidity and Mortality Weekly Report, vol.65, issue.3, pp.59-62, 2015.
DOI : 10.15585/mmwr.mm6503e2

J. C. Silbereis, S. Pochareddy, Y. Zhu, M. Li, and N. Sestan, The Cellular and Molecular Landscapes of the Developing Human Central Nervous System, Neuron, vol.89, issue.2, pp.248-268, 2016.
DOI : 10.1016/j.neuron.2015.12.008

Y. Sun, S. Pollard, L. Conti, M. Toselli, G. Biella et al., Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture, Molecular and Cellular Neuroscience, vol.38, issue.2, pp.245-258, 2008.
DOI : 10.1016/j.mcn.2008.02.014

M. S. Suthar, M. M. Brassil, G. Blahnik, A. Mcmillan, H. J. Ramos et al., A Systems Biology Approach Reveals that Tissue Tropism to West Nile Virus Is Regulated by Antiviral Genes and Innate Immune Cellular Processes, PLoS Pathogens, vol.37, issue.2, 2013.
DOI : 10.1371/journal.ppat.1003168.s004

J. Tailor, R. Kittappa, K. Leto, M. Gates, M. Borel et al., Stem Cells Expanded from the Human Embryonic Hindbrain Stably Retain Regional Specification and High Neurogenic Potency, Journal of Neuroscience, vol.33, issue.30, pp.12407-12422, 2013.
DOI : 10.1523/JNEUROSCI.0130-13.2013

URL : http://www.jneurosci.org/content/jneuro/33/30/12407.full.pdf

H. Tang, C. Hammack, S. C. Ogden, Z. Wen, X. Qian et al., Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth, Cell Stem Cell, vol.18, issue.5, pp.587-590, 2016.
DOI : 10.1016/j.stem.2016.02.016

URL : https://doi.org/10.1016/j.stem.2016.02.016

T. L. Thurston, G. Ryzhakov, S. Bloor, N. Von-muhlinen, R. et al., The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria, Nature Immunology, vol.3, issue.11, pp.1215-1221, 2009.
DOI : 10.1128/MCB.18.5.3069

C. G. Woods, Human microcephaly, Current Opinion in Neurobiology, vol.14, issue.1, pp.112-117, 2004.
DOI : 10.1016/j.conb.2004.01.003

K. Wu, G. Zuo, X. Li, Q. Ye, Y. Deng et al., Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice, Cell Research, vol.65, issue.6, pp.645-654, 2016.
DOI : 10.1093/bioinformatics/btp616

Y. Zhang, S. A. Sloan, L. E. Clarke, C. Caneda, C. A. Plaza et al., Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse, Neuron, vol.89, issue.1, pp.37-53, 2016.
DOI : 10.1016/j.neuron.2015.11.013

J. Zmurko, R. E. Marques, D. Schols, E. Verbeken, S. J. Kaptein et al., The viral polymerase inhibitor 7-deaza-2 0 -c-methyladenosine is a potent inhibitor of in vitro zika virus replication and delays disease progression in a robust mouse infection model, PLoS Negl. Trop. Dis, vol.10, p.4695, 2016.