Galactosaminogalactan of Aspergillus fumigatus, a bioactive fungal polymer.

Benoit Briard (1) , Laetitia Muszkieta (1) , Jean-Paul Latgé (1) , Thierry Fontaine (1)

1 Aspergillus

Galactosaminogalactan (GAG) is an extracellular polysaccharide produced by the mycelium of the opportunistic human fungal pathogen Aspergillus fumigatus GAG is the first polysaccharide described as a virulence factor in medical mycology. This review presents our current knowledge of the structural organization and biosynthesis of this polymer. The function of this molecule as an adhesin that also masks Aspergillus PAMPs and the impact of GAG on the modulation of the host immune response by inducing neutropenia and blocking the IL-1 signaling pathway also will be emphasised.

Keywords: virulence factor; neutrophil apoptosis; IL-1Ra; galactosaminogalactan; Aspergillus fumigatus

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Microbiology and Parasitology; Mycology

Benoit Briard, Laetitia Muszkieta, Jean-Paul Latgé, Thierry Fontaine. Galactosaminogalactan of Aspergillus fumigatus, a bioactive fungal polymer.. Mycologia, 2016, 108 (3), pp.572 - 580. ⟨10.3852/15-312⟩. ⟨pasteur-01725393⟩