W. C. De-groat, Anatomy and physiology of the lower urinary tract, Urol Clin North Am, vol.20, pp.383-401, 1993.
DOI : 10.1016/B978-0-444-63247-0.00005-5

H. O. Negrete, J. P. Lavelle, J. Berg, S. A. Lewis, and M. L. , Permeability properties of the intact mammalian bladder epithelium, American Journal of Physiology-Renal Physiology, vol.271, issue.4, pp.271-886, 1996.
DOI : 10.1152/ajprenal.1996.271.4.F886

K. E. Sivick and H. L. Mobley, Waging War against Uropathogenic Escherichia coli: Winning Back the Urinary Tract, Infection and Immunity, vol.78, issue.2, pp.78-568, 2010.
DOI : 10.1128/IAI.01000-09

R. M. Hicks, THE MAMMALIAN URINARY BLADDERAN ACCOMMODATING ORGAN, Biological Reviews, vol.4, issue.3, pp.215-246, 1975.
DOI : 10.1016/S0022-5193(69)80016-0

M. A. Ingersoll and M. L. Albert, From infection to immunotherapy: host immune responses to bacteria at the bladder mucosa, Mucosal Immunology, vol.48, issue.6, pp.1041-1053, 2013.
DOI : 10.1002/1097-0142(19810701)48:1<82::AID-CNCR2820480117>3.0.CO;2-Z

URL : https://hal.archives-ouvertes.fr/pasteur-01385511

R. A. Gardiner, G. J. Seymour, M. F. Lavin, G. M. Strutton, E. Gemmell et al., Immunohistochemical analysis of the human bladder, Br J Urol, pp.58-77, 1986.

S. N. Abraham and Y. Miao, The nature of immune responses to urinary tract infections, Nature Reviews Immunology, vol.52, issue.10, pp.655-663, 2015.
DOI : 10.1093/cid/ciq257

W. E. Thomas, E. Trintchina, M. Forero, V. Vogel, and E. V. Sokurenko, Bacterial Adhesion to Target Cells Enhanced by Shear Force, Cell, vol.109, issue.7, pp.109-913, 2002.
DOI : 10.1016/S0092-8674(02)00796-1

E. Miller, T. Garcia, S. Hultgren, and A. F. Oberhauser, The Mechanical Properties of E. coli Type 1 Pili Measured by Atomic Force Microscopy Techniques, Biophysical Journal, vol.91, issue.10, pp.91-3848, 2006.
DOI : 10.1529/biophysj.106.088989

J. Zakrisson, K. Wiklund, O. Axner, and M. Andersson, The Shaft of the Type 1 Fimbriae Regulates an External Force to Match the FimH Catch Bond, Biophysical Journal, vol.104, issue.10, pp.2137-2148, 2013.
DOI : 10.1016/j.bpj.2013.03.059

L. Brubaker and A. J. Wolfe, The female urinary microbiota, urinary health and common urinary disorders, Annals of Translational Medicine, vol.5, issue.34, 2017.
DOI : 10.21037/atm.2016.11.62

L. Brubaker and A. J. Wolfe, Associating infection and incontinence with the female urinary microbiota, Nature Reviews Urology, vol.14, issue.2, pp.72-74, 2017.
DOI : 10.3389/fcimb.2016.00078

E. E. Hilt, K. Mckinley, M. M. Pearce, A. B. Rosenfeld, M. J. Zilliox et al., Urine Is Not Sterile: Use of Enhanced Urine Culture Techniques To Detect Resident Bacterial Flora in the Adult Female Bladder, Journal of Clinical Microbiology, vol.52, issue.3, pp.52-871, 2014.
DOI : 10.1128/JCM.02876-13

D. A. Lewis, R. Brown, J. Williams, P. White, S. K. Jacobson et al., The human urinary microbiome; bacterial DNA in voided urine of asymptomatic adults, Frontiers in Cellular and Infection Microbiology, vol.3, p.41, 2013.
DOI : 10.3389/fcimb.2013.00041

D. E. Fouts, R. Pieper, S. Szpakowski, H. Pohl, S. Knoblach et al., Integrated next-generation sequencing of 16S rDNA and metaproteomics differentiate the healthy urine microbiome from asymptomatic bacteriuria in neuropathic bladder associated with spinal cord injury, Journal of Translational Medicine, vol.10, issue.1, p.10, 2012.
DOI : 10.1371/journal.ppat.1000949

R. Jauregui, D. Neubauer, D. H. Becher, M. Pieper, D. Jahn et al., A metaproteomics approach to elucidate host and pathogen protein expression during catheter-associated urinary tract infections (CAUTIs), Mol Cell Proteomics, pp.14-989, 2015.

S. A. Whiteside, H. Razvi, S. Dave, G. Reid, and J. P. Burton, The microbiome of the urinary tract???a role beyond infection, Nature Reviews Urology, vol.85, issue.2, pp.12-81, 2015.
DOI : 10.1016/j.mib.2013.09.008

H. Siddiqui, K. Lagesen, A. J. Nederbragt, S. L. Jeansson, and K. S. Jakobsen, Alterations of microbiota in urine from women with interstitial cystitis, BMC Microbiology, vol.12, issue.1, p.12, 2012.
DOI : 10.1016/j.mehy.2009.12.011

M. G. Abernethy, A. Rosenfeld, J. R. White, M. G. Mueller, C. Lewicky-gaupp et al., Urinary Microbiome and Cytokine Levels in Women With Interstitial Cystitis, Obstet Gynecol, pp.129-500, 2017.

B. Foxman and P. Brown, Epidemiology of urinary tract infections, Infectious Disease Clinics of North America, vol.17, issue.2, pp.227-241, 2003.
DOI : 10.1016/S0891-5520(03)00005-9

M. L. Wilson and L. Gaido, Laboratory Diagnosis of Urinary Tract Infections in Adult Patients, Clinical Infectious Diseases, vol.74, issue.8, pp.1150-1158, 2004.
DOI : 10.1086/520427

S. Esposito, V. Emmi, F. S. Mennini, F. Montorsi, G. Sganga et al., [Management and prevention of catheter-associated urinary tract infections: current opinions and clinical practice], Infez Med, pp.19-74, 2011.

G. C. Ulett, M. Totsika, K. Schaale, A. J. Carey, M. J. Sweet et al., Uropathogenic Escherichia coli virulence and innate immune responses during urinary tract infection, Current Opinion in Microbiology, vol.16, issue.1, pp.16-100, 2013.
DOI : 10.1016/j.mib.2013.01.005

D. J. Farrell, I. Morrissey, D. De-rubeis, M. Robbins, and D. Felmingham, A UK Multicentre Study of the Antimicrobial Susceptibility of Bacterial Pathogens Causing Urinary Tract Infection, Journal of Infection, vol.46, issue.2, pp.46-94, 2003.
DOI : 10.1053/jinf.2002.1091

P. A. Jordan, A. Iravani, G. A. Richard, and H. Baer, Urinary Tract Infection Caused by Staphylococcus saprophyticus, Journal of Infectious Diseases, vol.142, issue.4, pp.142-510, 1980.
DOI : 10.1093/infdis/142.4.510

G. Godaly, I. Ambite, and C. Svanborg, Innate immunity and genetic determinants of urinary tract infection susceptibility, Current Opinion in Infectious Diseases, vol.28, pp.88-96, 2015.
DOI : 10.1097/QCO.0000000000000127

C. S. Shibata, E. R. Fok, L. Mueller, A. J. Brubaker, K. A. Wolfe et al., Interplay between bladder microbiota and urinary antimicrobial peptides: mechanisms for human urinary tract infection risk and symptom severity, PLoS One, pp.9-114185, 2014.

. Hooton, Family history and risk of recurrent cystitis and pyelonephritis in women, J Urol, vol.184, pp.564-569, 2010.

D. Scholes, T. M. Hooton, P. L. Roberts, A. E. Stapleton, K. Gupta et al., Risk Factors for Recurrent Urinary Tract Infection in Young Women, The Journal of Infectious Diseases, vol.182, issue.4, pp.182-1177, 2000.
DOI : 10.1086/315827

C. L. Kiemeney, S. Vecchia, Y. Shariat, and . Lotan, Epidemiology and risk factors of urothelial bladder cancer, Eur Urol, vol.63, pp.234-241, 2013.

S. A. Zlotta and . Boorjian, Gender and Bladder Cancer: A Collaborative Review of Etiology, Biology, and Outcomes Eur Urol, pp.69-300, 2016.

S. Antoni, J. Ferlay, I. Soerjomataram, A. Znaor, A. Jemal et al., Bladder Cancer Incidence and Mortality: A Global Overview and Recent Trends, European Urology, vol.71, issue.1, pp.71-96, 2017.
DOI : 10.1016/j.eururo.2016.06.010

M. P. Zeegers, F. E. Tan, E. Dorant, P. A. Van-den, and . Brandt, The impact of characteristics of cigarette smoking on urinary tract cancer risk, Cancer, vol.29, issue.3, pp.89-630, 2000.
DOI : 10.1093/oxfordjournals.aje.a008955

. Bartonova, Bladder cancer, a review of the environmental risk factors, Environ Health, vol.11, issue.1, p.11, 2012.

M. H. Mostafa, S. A. Sheweita, and P. J. Connor, Relationship between schistosomiasis and bladder cancer, Clin Microbiol Rev, vol.12, pp.97-111, 1999.

M. Ploeg, K. K. Aben, and L. A. Kiemeney, The present and future burden of urinary bladder cancer in the world, World Journal of Urology, vol.102, issue.2, pp.289-293, 2009.
DOI : 10.1007/s00345-009-0383-3

A. S. Felix, A. S. Soliman, H. Khaled, M. S. Zaghloul, M. Banerjee et al., The changing patterns of bladder cancer in Egypt over the past 26??years, Cancer Causes & Control, vol.28, issue.4, pp.421-429, 2008.
DOI : 10.1016/0014-2964(79)90095-1

. Engels, Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa, Acta Trop, vol.86, pp.125-139, 2003.

S. S. Patnaik, A. S. Lagana, S. G. Vitale, S. Buttice, M. Noventa et al., Etiology, pathophysiology and biomarkers of interstitial cystitis/painful bladder syndrome, Archives of Gynecology and Obstetrics, vol.3, issue.286, pp.295-1341, 2017.
DOI : 10.1038/ncponc0636

P. Hanno, J. Nordling, and A. Van-ophoven, What is new in bladder pain syndrome/interstitial cystitis?, Current Opinion in Urology, vol.18, issue.4, pp.353-358, 2008.
DOI : 10.1097/MOU.0b013e3282fcea88

I. Offiah, A. Didangelos, J. Dawes, R. Cartwright, V. Khullar et al., The Expression of Inflammatory Mediators in Bladder Pain Syndrome, European Urology, vol.70, issue.2, pp.70-283, 2016.
DOI : 10.1016/j.eururo.2016.02.058

S. Grover, A. Srivastava, R. Lee, A. K. Tewari, and A. E. Te, Role of inflammation in bladder function and interstitial cystitis, Therapeutic Advances in Urology, vol.4, issue.1, pp.19-33, 2011.
DOI : 10.1046/j.1442-2042.10.s1.12.x

J. L. Boormans and E. C. Zwarthoff, Limited Funds for Bladder Cancer Research and What Can We Do About It, Bladder Cancer, vol.66, issue.2, pp.49-51, 2016.
DOI : 10.1016/j.eururo.2014.01.006

H. Kumar, T. Kawai, and S. Akira, Toll-like receptors and innate immunity, Biochemical and Biophysical Research Communications, vol.388, issue.4, pp.388-621, 2009.
DOI : 10.1016/j.bbrc.2009.08.062

J. D. Schilling, S. M. Martin, C. S. Hung, R. G. Lorenz, and S. J. Hultgren, Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli, Proceedings of the National Academy of Sciences, vol.381, issue.6577, pp.100-4203, 2003.
DOI : 10.1038/381077a0

B. Ragnarsdottir, N. Lutay, J. Gronberg-hernandez, B. Koves, and C. Svanborg, Genetics of innate immunity and UTI susceptibility, Nature Reviews Urology, vol.23, issue.8, pp.449-468, 2011.
DOI : 10.1007/s00383-006-1857-7

A. J. Carey, M. J. Sullivan, B. L. Duell, D. K. Crossman, D. Chattopadhyay et al., Uropathogenic Escherichia coli Engages CD14- Dependent Signaling to Enable Bladder-Macrophage-Dependent Control of Acute Urinary Tract Infection, J Infect Dis, pp.213-659, 2016.

E. Andersen-nissen, T. R. Hawn, K. D. Smith, A. E. Nachman, S. Lampano et al., Cutting Edge: Tlr5-/- Mice Are More Susceptible to Escherichia coli Urinary Tract Infection, The Journal of Immunology, vol.178, issue.8, pp.178-4717, 2007.
DOI : 10.4049/jimmunol.178.8.4717

URL : http://www.jimmunol.org/content/jimmunol/178/8/4717.full.pdf

J. Opdenakker, R. Bernhagen, U. Bucala, W. Panzer, H. J. Kolanus et al., Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium, Cell, pp.156-456, 2014.

J. Song and S. N. Abraham, Innate and adaptive immune responses in the urinary tract, European Journal of Clinical Investigation, vol.51, issue.Suppl. 3, pp.21-28, 2008.
DOI : 10.4049/jimmunol.175.6.3681

T. Rommler, Y. Muller, S. Zheng, O. Schubert, C. Gross et al., Uropathogenic Escherichia coli strain CFT073 disrupts NLRP3 inflammasome activation, J Clin Invest, pp.126-2425, 2016.

I. U. Schilling and . Mysorekar, ATG16L1 deficiency in macrophages drives clearance of uropathogenic E. coli in an IL-1beta-dependent manner, Mucosal Immunol, vol.8, pp.1388-1399, 2015.

K. Schaale, K. M. Peters, A. M. Murthy, A. K. Fritzsche, M. D. Phan et al., Strain- and host species-specific inflammasome activation, IL-1?? release and cell death in macrophages infected with uropathogenic Escherichia coli, Mucosal Immunology, vol.52, issue.1, pp.124-136, 2016.
DOI : 10.1111/j.1462-5822.2006.00751.x

N. J. Bokil, M. Totsika, A. J. Carey, K. J. Stacey, V. Hancock et al., Intramacrophage survival of uropathogenic Escherichia coli: Differences between diverse clinical isolates and between mouse and human macrophages, Immunobiology, vol.216, issue.11, pp.216-1164, 2011.
DOI : 10.1016/j.imbio.2011.05.011

N. Owusu-boaitey, K. A. Bauckman, T. Zhang, and I. U. Mysorekar, Macrophagic control of the response to uropathogenic E. coli infection by regulation of iron retention in an IL-6-dependent manner, pp.4-2016

S. Yona, K. W. Kim, Y. Wolf, A. Mildner, D. Varol et al., Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis, Immunity, pp.38-79, 2013.

Y. Lavin, D. Winter, R. Blecher-gonen, E. David, H. Keren-shaul et al., Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment, Cell, vol.159, issue.6, pp.159-1312, 2014.
DOI : 10.1016/j.cell.2014.11.018

M. Guilliams and B. Malissen, A Matter of Perspective: Moving from a Pre-omic to a Systems-Biology Vantage of Monocyte-Derived Cell Function and Nomenclature, Immunity, vol.44, issue.1, pp.44-49, 2016.
DOI : 10.1016/j.immuni.2015.12.020

URL : https://hal.archives-ouvertes.fr/hal-01440244

C. Jung and . Kurts, Tumor necrosis factor alpha-and inducible nitric oxide synthase-producing dendritic cells are rapidly recruited to the bladder in urinary tract infection but are dispensable for bacterial clearance, Infect Immun, pp.74-6100, 2006.

E. Kolaczkowska and P. Kubes, Neutrophil recruitment and function in health and inflammation, Nature Reviews Immunology, vol.121, issue.3, pp.159-175, 2013.
DOI : 10.1182/blood-2012-09-454348

M. Haraoka, L. Hang, B. Frendeus, G. Godaly, M. Burdick et al., Neutrophil Recruitment and Resistance to Urinary Tract Infection, The Journal of Infectious Diseases, vol.180, issue.4, pp.180-1220, 1999.
DOI : 10.1086/315006

URL : https://academic.oup.com/jid/article-pdf/180/4/1220/17994964/180-4-1220.pdf

M. A. Ingersoll, K. A. Kline, H. V. Nielsen, and S. J. Hultgren, G-CSF induction early in uropathogenic Escherichia coli infection of the urinary tract modulates host immunity, Cell Microbiol, pp.10-2568, 2008.

J. M. Daley, A. A. Thomay, M. D. Connolly, J. S. Reichner, and J. E. Albina, Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice, Journal of Leukocyte Biology, vol.53, issue.1, pp.83-64, 2008.
DOI : 10.1007/s00262-003-0443-2

G. Godaly, A. E. Proudfoot, R. E. Offord, C. Svanborg, and W. W. Agace, Role of epithelial interleukin-8 (IL-8) and neutrophil IL-8 receptor A in Escherichia coli-induced transuroepithelial neutrophil migration, Infect Immun, pp.65-3451, 1997.

G. Godaly, L. Hang, B. Frendeus, and C. Svanborg, Transepithelial Neutrophil Migration Is CXCR1 Dependent In Vitro and Is Defective in IL-8 Receptor Knockout Mice, The Journal of Immunology, vol.165, issue.9, pp.165-5287, 2000.
DOI : 10.4049/jimmunol.165.9.5287

E. R. Garcia-sastre, F. Stanley, P. S. Ginhoux, M. Frenette, and . Merad, Tissue-resident macrophages selfmaintain locally throughout adult life with minimal contribution from circulating monocytes, Immunity, pp.38-792, 2013.

M. Saluja and P. Gilling, Intravesical bacillus Calmette-Gu??rin instillation in non-muscle-invasive bladder cancer: A review, International Journal of Urology, vol.2, issue.3 Pt 1, 2017.
DOI : 10.3233/BLC-160056

M. Babjuk, W. Oosterlinck, R. Sylvester, E. Kaasinen, A. Bohle et al., European Association of, EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder, the 2011 update, Eur Urol, pp.59-997, 2011.

K. Chisholm and . James, Changes in urinary cytokines and soluble intercellular adhesion molecule-1

D. Bresson, S. Prie, C. Bechet, C. Baron, S. Sadorge et al., Molecular analyte profiling of the early events and tissue conditioning following intravesical bacillus calmette-guerin therapy in patients with superficial bladder cancer, J Urol, pp.181-1571, 2009.
URL : https://hal.archives-ouvertes.fr/pasteur-01402294

R. Gallucci and . Saban, Discriminators of mouse bladder response to intravesical Bacillus Calmette- Guerin (BCG), BMC Immunol, vol.8, issue.6, 2007.

G. Redelman-sidi, M. S. Glickman, and B. H. Bochner, The mechanism of action of BCG therapy for bladder cancer???a current perspective, Nature Reviews Urology, vol.59, issue.3, pp.11-153, 2014.
DOI : 10.1159/000283049

. Brandau, Neutrophil granulocytes are required for effective Bacillus Calmette-Guerin immunotherapy of bladder cancer and orchestrate local immune responses, Cancer Res, pp.66-8250, 2006.

T. L. Ratliff, J. K. Ritchey, J. J. Yuan, G. L. Andriole, and W. J. , Catalona, T-cell subsets required for intravesical BCG immunotherapy for bladder cancer, J Urol, pp.150-1018, 1993.

A. Auriau, P. Bachmann, C. Bousso, L. Demangel, G. N. Peduto et al., Preexisting BCG-specific T cells improve intravesical immunotherapy for bladder cancer, Sci Transl Med, pp.4-2012
URL : https://hal.archives-ouvertes.fr/pasteur-01402032

Y. Luo, H. Yamada, D. P. Evanoff, and X. Chen, Role of Th1-stimulating cytokines in bacillus Calmette-Guerin (BCG)-induced macrophage cytotoxicity against mouse bladder cancer MBT-2 cells, Clin Exp Immunol, pp.146-181, 2006.

Y. Luo, R. Han, D. P. Evanoff, and X. Chen, Interleukin-10 inhibits Mycobacterium bovis bacillus Calmette-Gu??rin (BCG)-induced macrophage cytotoxicity against bladder cancer cells, Clinical & Experimental Immunology, vol.63, issue.3, pp.160-359, 2010.
DOI : 10.4049/jimmunol.167.4.2227

URL : http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2249.2010.04105.x/pdf

T. Hanada, M. Nakagawa, A. Emoto, T. Nomura, N. Nasu et al., Prognostic value of tumor-associated macrophage count in human bladder cancer, International Journal of Urology, vol.160, issue.7, pp.263-269, 2000.
DOI : 10.1016/S0022-5347(01)62747-2

. Nonomura, Increased infiltration of tumor associated macrophages is associated with poor prognosis of bladder carcinoma in situ after intravesical bacillus Calmette-Guerin instillation, J Urol, pp.181-1894, 2009.

. Fradet, Bladder tumor infiltrating mature dendritic cells and macrophages as predictors of response to bacillus Calmette-Guerin immunotherapy, Eur Urol, pp.55-1386, 2009.

L. Lima, D. Oliveira, A. Tavares, T. Amaro, R. Cruz et al., The predominance of M2-polarized macrophages in the stroma of low-hypoxic bladder tumors is associated with BCG immunotherapy failure, Urol Oncol, pp.32-449, 2014.

E. J. Askeland, M. R. Newton, M. A. O-'donnell, and Y. Luo, Bladder Cancer Immunotherapy: BCG and Beyond, Advances in Urology, vol.187, issue.5, pp.2012-181987, 2012.
DOI : 10.1016/j.juro.2012.01.030

URL : http://downloads.hindawi.com/journals/au/2012/181987.pdf

C. L. Fu, J. I. Odegaard, D. R. Herbert, and M. H. Hsieh, A Novel Mouse Model of Schistosoma haematobium Egg-Induced Immunopathology, PLoS Pathogens, vol.27, issue.Pt 2, p.1002605, 2012.
DOI : 10.1371/journal.ppat.1002605.s004

C. L. Fu, J. I. Odegaard, and M. H. Hsieh, Macrophages are required for host survival in experimental urogenital schistosomiasis, The FASEB Journal, vol.160, issue.53, pp.29-193, 2015.
DOI : 10.1371/journal.pntd.0001421

T. A. Wynn, A. Chawla, and J. W. Pollard, Macrophage biology in development, homeostasis and disease, Nature, vol.6, issue.7446, pp.496-445, 2013.
DOI : 10.1038/nprot.2011.376

J. P. Lang and . Iredale, Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair, J Clin Invest, vol.115, pp.56-65, 2005.

S. Pfeilschifter and . Frank, A transgenic mouse model of inducible macrophage depletion: effects of diphtheria toxin-driven lysozyme M-specific cell lineage ablation on wound inflammatory, angiogenic, and contractive processes, Am J Pathol, pp.175-132, 2009.

. Simeonova, Macrophages and skeletal muscle regeneration: a clodronate-containing liposome depletion study, Am J Physiol Regul Integr Comp Physiol, pp.290-1488, 2006.

M. J. Van-amerongen, M. C. Harmsen, N. Van-rooijen, A. H. Petersen, and M. J. Van-luyn, Macrophage Depletion Impairs Wound Healing and Increases Left Ventricular Remodeling after Myocardial Injury in Mice, The American Journal of Pathology, vol.170, issue.3, pp.818-829, 2007.
DOI : 10.2353/ajpath.2007.060547

. Apodaca, Stretch-regulated exocytosis/endocytosis in bladder umbrella cells, Mol Biol Cell, vol.13, pp.830-846, 2002.