Galactosaminogalactan, a New Immunosuppressive Polysaccharide of Aspergillus fumigatus - Institut Pasteur Accéder directement au contenu
Article Dans Une Revue PLoS Pathogens Année : 2011

Galactosaminogalactan, a New Immunosuppressive Polysaccharide of Aspergillus fumigatus

Thierry Fontaine
Connectez-vous pour contacter l'auteur
Aurélie Delangle
  • Fonction : Auteur
Carole Elbim
  • Fonction : Auteur
  • PersonId : 843422
  • IdRef : 092904815
Jean-Paul Latgé
  • Fonction : Auteur
  • PersonId : 835028

Résumé

A new polysaccharide secreted by the human opportunistic fungal pathogen Aspergillus fumigatus has been characterized. Carbohydrate analysis using specific chemical degradations, mass spectrometry, ¹H and ¹³C nuclear magnetic resonance showed that this polysaccharide is a linear heterogeneous galactosaminogalactan composed of α1-4 linked galactose and α1-4 linked N-acetylgalactosamine residues where both monosacharides are randomly distributed and where the percentage of galactose per chain varied from 15 to 60%. This polysaccharide is antigenic and is recognized by a majority of the human population irrespectively of the occurrence of an Aspergillus infection. GalNAc oligosaccharides are an essential epitope of the galactosaminogalactan that explains the universal antibody reaction due to cross reactivity with other antigenic molecules containing GalNAc stretches such as the N-glycans of Campylobacter jejuni. The galactosaminogalactan has no protective effect during Aspergillus infections. Most importantly, the polysaccharide promotes fungal development in immunocompetent mice due to its immunosuppressive activity associated with disminished neutrophil infiltrates.

Domaines

Mycologie
Fichier principal
Vignette du fichier
journal.ppat.1002372.pdf (1.11 Mo) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

pasteur-01721100 , version 1 (01-03-2018)

Licence

Paternité

Identifiants

Citer

Thierry Fontaine, Aurélie Delangle, Catherine Simenel, Bernadette Coddeville, Sandra J. van Vliet, et al.. Galactosaminogalactan, a New Immunosuppressive Polysaccharide of Aspergillus fumigatus. PLoS Pathogens, 2011, 7 (11), pp.e1002372. ⟨10.1371/journal.ppat.1002372⟩. ⟨pasteur-01721100⟩
190 Consultations
217 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More