β(1,3)-Glucanosyl-Transferase Activity Is Essential for Cell Wall Integrity and Viability of Schizosaccharomyces pombe

Maria de Medina-Redondo (1) , Yolanda Arnáiz-Pita (1) , Cécile Clavaud (2) , Thierry Fontaine (2) , Francisco del Rey (1) , Jean-Paul Latge (2) , Carlos Vázquez de Aldana (1)

1 CSIC - Consejo Superior de Investigaciones Cientificas [España] = Spanish National Research Council [Spain]
2 Aspergillus

The formation of the cell wall in Schizosaccharomyces pombe requires the coordinated activity of enzymes involved in the biosynthesis and modification of β-glucans. The β(1,3)-glucan synthase complex synthesizes linear β(1,3)-glucans, which remain unorganized until they are cross-linked to other β(1,3)-glucans and other cell wall components. Transferases of the GH72 family play important roles in cell wall assembly and its rearrangement in Saccharomyces cerevisiae and Aspergillus fumigatus. Four genes encoding β(1,3)-glucanosyl-transferases -gas1(+), gas2(+), gas4(+) and gas5(+)- are present in S. pombe, although their function has not been analyzed.

Domaines: Sciences du Vivant [q-bio]; Mycologie

Maria de Medina-Redondo, Yolanda Arnáiz-Pita, Cécile Clavaud, Thierry Fontaine, Francisco del Rey, et al.. β(1,3)-Glucanosyl-Transferase Activity Is Essential for Cell Wall Integrity and Viability of Schizosaccharomyces pombe. PLoS ONE, 2010, 5 (11), pp.e14046. ⟨10.1371/journal.pone.0014046⟩. ⟨pasteur-01719931⟩