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Cell wall α1-3glucans induce the aggregation of germinating conidia of Aspergillus fumigatus

Abstract : The germination of Aspergillus fumigatus conidia can be divided into four stages: breaking of dormancy, isotropic swelling, establishment of cell polarity, and formation of a germ tube. Swelling of conidia is associated in liquid medium with a multi-cellular aggregation that produced large clumps of conidia. Conidial aggregation can be specifically prevented by the addition of alpha1-3glucanase. Swollen conidia specifically adhere to insoluble alpha1-3glucan chains. Electron microscopy studies showed that cell wall alpha1-3glucan chains became exposed at the cell surface during the swelling. These results demonstrate that cell wall alpha1-3glucans play an essential role in the aggregation between swollen conidia. Experiments with alpha1-3glucan coated latex beads show that alpha1-3glucan chains interacted between them without the requirement of any other cell wall component suggesting that biophysical properties of alpha1-3glucans are solely responsible for conidial aggregation.
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Submitted on : Wednesday, February 28, 2018 - 12:03:11 PM
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Thierry Fontaine, Anne Beauvais, Celine Loussert, Benoit B. Thevenard, Claus C. Fulgsang, et al.. Cell wall α1-3glucans induce the aggregation of germinating conidia of Aspergillus fumigatus. Fungal Genetics and Biology, Elsevier, 2010, 47 (8), pp.707 - 712. ⟨10.1016/j.fgb.2010.04.006⟩. ⟨pasteur-01719601⟩



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