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Functional determinants by which snake and cone snail toxins block the alpha 7 neuronal nicotinic acetylcholine receptors.

Abstract : Snakes and cone snails produce toxins which block muscular and/or neuronal nicotinic acetylcholine receptors (AChRs). This paper mostly focuses on the determinants by which a snake long chain curaremimetic toxin and the cone snail toxin ImI bind specifically to the alpha 7 neuronal receptor. In both cases, the site involves a small turn-like structure constrained by two half-cystines.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01718432
Contributor : Ana Cova Rodrigues <>
Submitted on : Tuesday, February 27, 2018 - 1:56:42 PM
Last modification on : Wednesday, October 14, 2020 - 4:16:14 AM

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Denis Servent, Hung Lam Thanh, Stéphanie Antil, Daniel Bertrand, Pierre-Jean Corringer, et al.. Functional determinants by which snake and cone snail toxins block the alpha 7 neuronal nicotinic acetylcholine receptors.. Journal of Physiology - Paris, Elsevier, 1998, 92 (2), pp.107-11. ⟨10.1016/S0928-4257(98)80146-0⟩. ⟨pasteur-01718432⟩

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