Questions on viral population biology to complete dengue puzzle

Christine Chevillon (1) , Anna-Bella Failloux (2)

1 CEPM - Centre d'Etude sur le Polymorphisme des Micro-Organismes
2 Ecologie des Systèmes Vectoriels

The mechanisms driving the current evolution of dengue remain unclear. We argue that disregarding the population biology of viruses has been a limiting factor, and present a hypothetical framework based on viral population biology. This allows us to pinpoint three flaws that need to be addressed: (1) a large underestimation of the viral polymorphism within populations; (2) a disregard of viral loci other than that encoding the antigenic envelope; and (3) the neglect of host-driven selection, especially that of vector-driven selection.

Domaines: Virologie

Christine Chevillon, Anna-Bella Failloux. Questions on viral population biology to complete dengue puzzle. Trends in Microbiology, 2003, 11 (9), pp.415 - 421. ⟨10.1016/S0966-842X(03)00206-3⟩. ⟨pasteur-01713414⟩