Abstract : The mechanisms driving the current evolution of dengue remain unclear. We argue that disregarding the population biology of viruses has been a limiting factor, and present a hypothetical framework based on viral population biology. This allows us to pinpoint three flaws that need to be addressed: (1) a large underestimation of the viral polymorphism within populations; (2) a disregard of viral loci other than that encoding the antigenic envelope; and (3) the neglect of host-driven selection, especially that of vector-driven selection.
https://hal-pasteur.archives-ouvertes.fr/pasteur-01713414 Contributor : MARIE DEMESLAY GOUGAMConnect in order to contact the contributor Submitted on : Tuesday, February 20, 2018 - 3:25:49 PM Last modification on : Thursday, April 7, 2022 - 10:10:34 AM Long-term archiving on: : Monday, May 21, 2018 - 1:24:01 PM