Skip to Main content Skip to Navigation
Journal articles

A Wolbachia wMel Transinfection in Aedes albopictus Is Not Detrimental to Host Fitness and Inhibits Chikungunya Virus

Abstract : Background: Wolbachia inherited intracellular bacteria can manipulate the reproduction of their insect hosts through cytoplasmic incompatibility (CI), and certain strains have also been shown to inhibit the replication or dissemination of viruses. Wolbachia strains also vary in their relative fitness effects on their hosts and this is a particularly important consideration with respect to the potential of newly created transinfections for use in disease control. Methodology/Principal Findings In Aedes albopictus mosquitoes transinfected with the wMel strain from Drosophila melanogaster, which we previously reported to be unable to transmit dengue in lab challenges, no significant detrimental effects were observed on egg hatch rate, fecundity, adult longevity or male mating competitiveness. All these parameters influence the population dynamics of Wolbachia, and the data presented are favourable with respect to the aim of taking wMel to high population frequency. Challenge with the chikungunya (CHIKV) virus, for which Ae. albopictus is an important vector, was conducted and the presence of wMel abolished CHIKV dissemination to the saliva. Conclusions/significance Taken together, these data suggest that introducing wMel into natural Ae. albopictus populations using bidirectional CI could be an efficient strategy for preventing or reducing the transmission of arboviruses by this species.
Document type :
Journal articles
Complete list of metadatas

Cited literature [39 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-01680359
Contributor : Marie Demeslay Gougam <>
Submitted on : Wednesday, January 10, 2018 - 4:03:25 PM
Last modification on : Monday, January 13, 2020 - 5:08:15 PM
Long-term archiving on: : Friday, May 4, 2018 - 3:48:38 AM

File

A Wolbachia ... Virus.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Marcus Blagrove, Camilo Arias-Goeta, Cristina Genua, Anna-Bella Failloux, Steven Sinkins. A Wolbachia wMel Transinfection in Aedes albopictus Is Not Detrimental to Host Fitness and Inhibits Chikungunya Virus. PLoS Neglected Tropical Diseases, Public Library of Science, 2013, 7 (3), pp.e2152. ⟨10.1371/journal.pntd.0002152⟩. ⟨pasteur-01680359⟩

Share

Metrics

Record views

119

Files downloads

233