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Journal articles
Modular total syntheses of mycolactone A/B and its [ 2 H]- isotopologue
Abstract : A modular total synthesis of mycolactone A/B, the exotoxin produced by Mycobacterium ulcerans has been achieved through the orchestration of several Pd-catalyzed key steps. While this route leads to a mixture of the natural product and its C12 epimer (4:1 ratio), this was inconsequential from the biological activity standpoint. Compared to previously reported routes, this synthetic blueprint allows the late-stage modification of the toxin, as exemplified with the preparation of [22,22,22-2
Cited literature [3 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-01666631
Contributor : Marie-Luce Kop <>
Submitted on : Monday, December 18, 2017 - 3:46:07 PM
Last modification on : Thursday, July 30, 2020 - 3:14:15 AM
Contributor : Marie-Luce Kop <>
Submitted on : Monday, December 18, 2017 - 3:46:07 PM
Last modification on : Thursday, July 30, 2020 - 3:14:15 AM