Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak

Isabelle Schuffenecker (1) , Isabelle Iteman (2) , Alain Michault (3) , Severine Murri (1) , Lionel Frangeul (4) , Marie-Christine Vaney (5) , Rachel Lavenir (2) , Nathalie Pardigon (6) , Jean-Marc Rey (7) , François Pettinelli (8) , Leon Biscornet (9) , Laure Diancourt (2) , Stephanie Michel (1) , Stéphane Duquerroy (10, 5) , Ghislaine Guigon (2) , Marie-Pascale Frenkiel (6) , Anne-Claire Bréhin (6) , Nadège Cubito (1) , Philippe Desprès (6) , Frank Kunst (11) , Félix A. Rey (5) , Hervé Zeller (1) , Sylvain Brisse (2)

1 Centre national de Référence et Centre Collaborateur de l'OMS Arbovirus (CNR-CCOMS)
2 PF8 - Génotypage des Pathogènes et Santé Publique (Plate-forme)
3 GHSR - Groupe Hospitalier Sud Réunion
4 PF4 - Intégration et Analyse Génomique (Plate-Forme 4)
5 Virologie Structurale
6 Interactions Moléculaires Flavivirus-Hôtes
7 IPM - Unité de Virologie [Antananarivo, Madagascar]
8 CHM - Laboratory of the Hospital Centre of Mayotte
9 Seychelles Public Health Laboratory
10 UP11 - Université Paris-Sud - Paris 11
11 Génomique des Microorganismes Pathogènes

A chikungunya virus outbreak of unprecedented magnitude is currently ongoing in Indian Ocean territories. In Réunion Island, this alphavirus has already infected about one-third of the human population. The main clinical symptom of the disease is a painful and invalidating poly-arthralgia. Besides the arthralgic form, 123 patients with a confirmed chikungunya infection have developed severe clinical signs, i.e., neurological signs or fulminant hepatitis.

Mots clés: SEMLIKI-FOREST-VIRUS; ONYONG-NYONG VIRUSES; ROSS RIVER; CHOLESTEROL DEPENDENCE; SEQUENCE ALIGNMENT; DISEASE; FEVER; IDENTIFICATION

Mots clés: REPLICATION; EVOLUTION; INSECTE; EPIDEMIOLOGIE HUMAINE

Domaines: Santé publique et épidémiologie

Isabelle Schuffenecker, Isabelle Iteman, Alain Michault, Severine Murri, Lionel Frangeul, et al.. Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak. PLoS Medicine, 2006, 3 (7), pp.e263. ⟨10.1371/journal.pmed.0030263⟩. ⟨pasteur-01659363⟩