Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak

Abstract : A chikungunya virus outbreak of unprecedented magnitude is currently ongoing in Indian Ocean territories. In Réunion Island, this alphavirus has already infected about one-third of the human population. The main clinical symptom of the disease is a painful and invalidating poly-arthralgia. Besides the arthralgic form, 123 patients with a confirmed chikungunya infection have developed severe clinical signs, i.e., neurological signs or fulminant hepatitis.
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Isabelle Schuffenecker, Isabelle Iteman, Alain Michault, Severine Murri, Lionel Frangeul, et al.. Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak. PLoS Medicine, Public Library of Science, 2006, 3 (7), pp.e263. ⟨10.1371/journal.pmed.0030263⟩. ⟨pasteur-01659363⟩

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