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Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak

Isabelle Schuffenecker 1 Isabelle Iteman 2 Alain Michault 3 Severine Murri 1 Lionel Frangeul 4 Marie-Christine Vaney 5 Rachel Lavenir 2 Nathalie Pardigon 6 Jean-Marc Rey 7 François Pettinelli 8 Leon Biscornet 9 Laure Diancourt 2 Stephanie Michel 1 Stéphane Duquerroy 10, 5 Ghislaine Guigon 2 Marie-Pascale Frenkiel 6 Anne-Claire Bréhin 6 Nadège Cubito 1 Philippe Desprès 6 Frank Kunst 11 Félix A. Rey 5 Hervé Zeller 1 Sylvain Brisse 2
1 Centre national de Référence et Centre Collaborateur de l'OMS Arbovirus (CNR-CCOMS)
2 PF8 - Génotypage des Pathogènes et Santé Publique (Plate-forme)
3 GHSR - Groupe Hospitalier Sud Réunion
4 PF4 - Intégration et Analyse Génomique (Plate-Forme 4)
5 Virologie Structurale
6 Interactions Moléculaires Flavivirus-Hôtes
7 IPM - Unité de Virologie [Antananarivo, Madagascar]
8 CHM - Laboratory of the Hospital Centre of Mayotte
9 Seychelles Public Health Laboratory
10 UP11 - Université Paris-Sud - Paris 11
11 Génomique des Microorganismes Pathogènes
Abstract : A chikungunya virus outbreak of unprecedented magnitude is currently ongoing in Indian Ocean territories. In Réunion Island, this alphavirus has already infected about one-third of the human population. The main clinical symptom of the disease is a painful and invalidating poly-arthralgia. Besides the arthralgic form, 123 patients with a confirmed chikungunya infection have developed severe clinical signs, i.e., neurological signs or fulminant hepatitis.
Keywords : SEMLIKI-FOREST-VIRUS ONYONG-NYONG VIRUSES ROSS RIVER CHOLESTEROL DEPENDENCE SEQUENCE ALIGNMENT DISEASE FEVER IDENTIFICATION
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Isabelle Schuffenecker, Isabelle Iteman, Alain Michault, Severine Murri, Lionel Frangeul, et al.. Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak. PLoS Medicine, Public Library of Science, 2006, 3 (7), pp.e263. ⟨10.1371/journal.pmed.0030263⟩. ⟨pasteur-01659363⟩

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