The role of the gut as a primary lymphoid organ: CD8αα intraepithelial T lymphocytes in euthymic mice derive from very immature CD44+ thymocyte precursors

Abstract : Intestinal CD8αα intraepithelial T lymphocytes (T-IELs) have a key role in mucosal immunity and, unlike other T cells, were proposed to differentiate locally. In apparent contradiction, these cells were also shown to originate from a wave of thymus migrants colonizing the gut in the first 3 weeks after birth. We here identify previously uncharacterized very immature CD4(-)CD8(-)CD3(-)CD44(+)CD25(int) thymocytes, which have not yet rearranged their T-cell antigen receptor (TCR), as having the capacity to leave the thymus, migrate to the blood, colonize the gut, and reconstitute CD8αα T-IEL, and show that this cell set is fully responsible for the generation of the CD8αα T-IEL pool. Thus, although the thymus may be fundamental for efficient T-cell commitment, CD8αα T-IEL' complete TCR rearrangements and TCR-αβ/γδ lineage commitment must occur in the gut. These results demonstrate a major role of the gut environment as a primary lymphoid organ.
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Mucosal Immunology, Nature Pub. Group, 2010, 4 (1), pp.93 - 101. 〈10.1038/mi.2010.47〉
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Contributeur : Nathalie Pardigon <>
Soumis le : vendredi 8 décembre 2017 - 12:22:00
Dernière modification le : lundi 18 décembre 2017 - 10:22:02

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P Peaudecerf, S Ribeiro dos Santos, B Boudil, S Ezine, N. Pardigon, et al.. The role of the gut as a primary lymphoid organ: CD8αα intraepithelial T lymphocytes in euthymic mice derive from very immature CD44+ thymocyte precursors. Mucosal Immunology, Nature Pub. Group, 2010, 4 (1), pp.93 - 101. 〈10.1038/mi.2010.47〉. 〈pasteur-01659344〉

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