Absence of the T-bet gene coding for the Th1-related transcription factor does not affect diabetes-associated phenotypes in Balb/c mice.

Abstract : The T-box expressed in T cells gene (T-bet) is a member of the T-box family of transcription factors. T-bet-deficient mice show normal lymphoid development, but exhibit profound defects in their Th1-mediated immune responses. As the balance between Th1- and Th2-mediated immune responses plays a role in autoimmune-prone diseases, we have investigated the diabetes-related insulin autoantibody (IAA) and cellular immune responses (insulitis), in the absence of Th1 lineage commitment, in T-bet KO Balb/c mice, after immunization with the B9-23 insulin peptide. We have therefore investigated whether absence of the T-bet gene influences diabetes-related phenotypes in Balb/c T-bet KO mice.
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Contributeur : Evie Melanitou <>
Soumis le : mardi 21 novembre 2017 - 16:19:26
Dernière modification le : mercredi 29 novembre 2017 - 15:59:07

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Evie Melanitou, Edwin Liu, Dongmei Miao, Liping Yu, Laurie H Glimcher, et al.. Absence of the T-bet gene coding for the Th1-related transcription factor does not affect diabetes-associated phenotypes in Balb/c mice.. Annals of the New York Academy of Sciences, Wiley, 2003, IMMUNOLOGY OF DIABETES II: PATHOGENESIS FROM MOUSE TO MAN, 1005, pp.187-91. 〈10.1196/annals.1288.024〉. 〈pasteur-01643784〉

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