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Journal articles
Interferon-alpha as a mediator of polyinosinic:polycytidylic acid-induced type 1 diabetes.
Abstract : A number of studies and clinical case reports have implicated interferon (IFN)-alpha as a potential mediator of type 1 diabetes pathogenesis. Administration of polyinosinic:polycytidylic acid (poly I:C), a mimic of viral double-stranded RNA, induces diabetes in C57BL/6 mice expressing the B7.1 costimulatory molecule in islets. We investigated the potential role of IFN-alpha in this disease model. The quantitative correlation between IFN-alpha levels and time to diabetes, diabetes prevention with anti-IFN-alpha antibody, and ability of IFN-alpha itself to induce diabetes are consistent with the hypothesis that poly I:C in this model acts by induction of IFN-alpha in a genetically susceptible host. Numerous recent studies highlight the importance of the innate immune system and toll receptors in determining adaptive immune responses, and we speculate that for type 1 diabetes, viral and other environmental factors may act through induction of IFNs.
Cited literature [36 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-01643740
Contributor : Evie Melanitou Connect in order to contact the contributor
Submitted on : Tuesday, November 21, 2017 - 3:56:34 PM
Last modification on : Tuesday, October 25, 2022 - 4:48:24 PM
Contributor : Evie Melanitou Connect in order to contact the contributor
Submitted on : Tuesday, November 21, 2017 - 3:56:34 PM
Last modification on : Tuesday, October 25, 2022 - 4:48:24 PM