Early over expression of messenger RNA for multiple genes, including insulin, in the Pancreatic Lymph Nodes of NOD mice is associated with Islet Autoimmunity

Abstract : Background: Autoimmune diabetes (T1D) onset is preceded by a long inflammatory process directed against the insulin-secreting β cells of the pancreas. Deciphering the early autoimmune mechanisms represents a challenge due to the absence of clinical signs at early disease stages. The aim of this study was to identify genes implicated in the early steps of the autoimmune process, prior to inflammation, in T1D. We have previously established that insulin autoantibodies (E-IAA) predict early diabetes onset delineating an early phenotypic check point (window 1) in disease pathogenesis. We used this sub-phenotype and applied differential gene expression analysis in the pancreatic lymph nodes (PLN) of 5 weeks old Non Obese Diabetic (NOD) mice differing solely upon the presence or absence of E-IAA. Analysis of gene expression profiles has the potential to provide a global understanding of the disease and to generate novel hypothesis concerning the initiation of the autoimmune process.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01643691
Contributeur : Evie Melanitou <>
Soumis le : mardi 21 novembre 2017 - 15:48:25
Dernière modification le : mercredi 6 décembre 2017 - 11:24:35

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1755-8794-2-63 BMC Med Gen.pdf
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Distributed under a Creative Commons Paternité 4.0 International License

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Béatrice Regnault, José Osorio y Fortéa, Dongmei Miao, George Eisenbarth, Evie Melanitou. Early over expression of messenger RNA for multiple genes, including insulin, in the Pancreatic Lymph Nodes of NOD mice is associated with Islet Autoimmunity. BMC Medical Genomics, BioMed Central, In press, 2 (63), 〈10.1186/1755-8794-2-63〉. 〈pasteur-01643691〉

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