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Journal articles
Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents
Abstract : We report the design and synthesis of a series of non-nucleoside MtbTMPK inhibitors (1-14) based on the gram-positive bacterial TMPK inhibitor hit compound 1. A practical synthesis was developed to access these analogues. Several compounds show promising MtbTMPK inhibitory potency and allow the establishment of a structure-activity relationship, which is helpful for further optimization.
Cited literature [11 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-01616045
Contributor : Hélène Munier-Lehmann Connect in order to contact the contributor
Submitted on : Friday, October 13, 2017 - 2:57:08 PM
Last modification on : Thursday, April 7, 2022 - 10:10:33 AM
Long-term archiving on: : Sunday, January 14, 2018 - 1:32:56 PM
Contributor : Hélène Munier-Lehmann Connect in order to contact the contributor
Submitted on : Friday, October 13, 2017 - 2:57:08 PM
Last modification on : Thursday, April 7, 2022 - 10:10:33 AM
Long-term archiving on: : Sunday, January 14, 2018 - 1:32:56 PM
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BMC_R1_final.pdf
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