10NutriNeur0 - Nutrition et Neurobiologie intégrée (NutriNeuro UMR INRA 1286 Université Bordeaux Segalen Bâtiment UFR de Pharmacie 2e tranche, 2e étage, Case Courrier 34 146 rue Léo Saignat 33076 Bordeaux cedex - France)
Abstract : Hunger arouses sensory perception, eventually leading to an increase in food intake, but the underlying mechanisms remain poorly understood. We found that cannabinoid type-1 (CB1) receptors promote food intake in fasted mice by increasing odor detection. CB1 receptors were abundantly expressed on axon terminals of centrifugal cortical glutamatergic neurons that project to inhibitory granule cells of the main olfactory bulb (MOB). Local pharmacological and genetic manipulations revealed that endocannabinoids and exogenous cannabinoids increased odor detection and food intake in fasted mice by decreasing excitatory drive from olfactory cortex areas to the MOB. Consistently, cannabinoid agonists dampened in vivo optogenetically stimulated excitatory transmission in the same circuit. Our data indicate that cortical feedback projections to the MOB crucially regulate food intake via CB1 receptor signaling, linking the feeling of hunger to stronger odor processing. Thus, CB1 receptor-dependent control of cortical feedback projections in olfactory circuits couples internal states to perception and behavior.
https://hal-pasteur.archives-ouvertes.fr/pasteur-01587186
Contributeur : Antoine Nissant
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Soumis le : mercredi 13 septembre 2017 - 17:47:45
Dernière modification le : lundi 18 mars 2019 - 16:52:02
Edgar Soria-Gómez, Luigi Bellocchio, Leire Reguero, Gabriel Lepousez, Claire Martin, et al.. The endocannabinoid system controls food intake via olfactory processes. Nature Neuroscience, Nature Publishing Group, 2014, 17 (3), pp.407 - 415. 〈10.1038/nn.3647〉. 〈pasteur-01587186〉
