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Journal articles
The endocannabinoid system controls food intake via olfactory processes
Edgar Soria-Gómez
1
Luigi Bellocchio
2, 3
Leire Reguero
4
Gabriel Lepousez
5
Claire Martin
6
Mounir Bendahmane
6
Sabine Ruehle
7
Floor Remmers
7
Tiffany Desprez
1
Isabelle Matias
1
Theresa Wiesner
1
Astrid Cannich
1
Antoine Nissant
5
Aya Wadleigh
1
Hans-Christian Pape
8
Anna Paola Chiarlone
2, 3
Carmelo Quarta
9
Danièle Verrier
1
Peggy Vincent
1
Federico Massa
1
Beat Lutz
7
Manuel Guzmán
2, 3
Hirac Gurden
6
Guillaume Ferreira
10
Pierre-Marie Lledo
5
Pedro Grandes
4
Giovanni Marsicano
1, *
*
Corresponding author
Edgar Soria-Gómez 1
Author
Luigi Bellocchio 2, 3
Author
Leire Reguero 4
Author
Gabriel Lepousez 5
Author IdHAL : gabriel-lepousez IdRef : https://www.idref.fr/142830992 ORCID : https://orcid.org/0000-0002-9390-7749 VIAF : https://viaf.org/viaf/198090804 ISNI : http://isni.org/isni/0000000357401203
Claire Martin 6
Author IdHAL : clairmar ORCID : https://orcid.org/0000-0001-5340-8323
Mounir Bendahmane 6
Author
Sabine Ruehle 7
Author
Floor Remmers 7
Author
Antoine Nissant 5
Author
Aya Wadleigh 1
Author
Hans-Christian Pape 8
Author
Anna Paola Chiarlone 2, 3
Author
1
Physiopathologie du système nerveux central - Institut François Magendie (Institut Francois Magendie 146, rue leo saignat 33077 BORDEAUX CEDEX - France)
- Université Bordeaux Segalen - Bordeaux 2 (146 rue Léo Saignat - 33076 Bordeaux cedex - France)
- IFR8 (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U862 (101, rue de Tolbiac, 75013 Paris - France)
2
CIBERNED - Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas (Avda. de Séneca, 2 - Ciudad Universitaria - 28040 Madrid - Spain)
- ISC - Instituto de Salud Carlos III [Madrid] ( Carretera de Majadahonda - Pozuelo, 28220 Majadahonda, Madrid, Espagne - Spain)
3
UCM - Complutense University of Madrid (Avda. de Séneca, 2, Ciudad Universitaria, 28040 Madrid - Spain)
5
Perception et Mémoire (Département de Neuroscience - 25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR3571 (France)
6
IMNC (UMR_8165) - Imagerie et Modélisation en Neurobiologie et Cancérologie (Université Paris Sud - Bâtiment 440
15 rue Georges Clémenceau
91405 Orsay Cedex - France - France)
- UP11 - Université Paris-Sud - Paris 11 (Bâtiment 300 - 91405 Orsay cedex - France)
- IN2P3 - Institut National de Physique Nucléaire et de Physique des Particules du CNRS (France)
- UPD7 - Université Paris Diderot - Paris 7 : UMR_8165 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR_8165 (France)
7
JGU - Johannes Gutenberg - Universität Mainz (55099 Mainz - Germany)
8
WWU - Westfälische Wilhelms-Universität Münster (Universität Münster Schlossplatz 2 48149 Münster - Germany)
9
University of Bologna (Via Zamboni, 33 - 40126 Bologna - Italy)
10
NutriNeur0 - Nutrition et Neurobiologie intégrée (NutriNeuro UMR INRA 1286 Université Bordeaux Segalen Bâtiment UFR de Pharmacie 2e tranche, 2e étage, Case Courrier 34 146 rue Léo Saignat 33076 Bordeaux cedex - France)
- Ecole nationale supérieure de chimie, biologie et physique (France)
- Institut Polytechnique de Bordeaux (146, rue Léo Saignat, 33076 Bordeaux - France)
- Université Sciences et Technologies - Bordeaux 1 (351 cours de la Libération - 33405 Talence cedex - France)
- INRA - Institut National de la Recherche Agronomique : UMR1286 (France)
- Université Bordeaux Segalen - Bordeaux 2 (146 rue Léo Saignat - 33076 Bordeaux cedex - France)
Abstract : Hunger arouses sensory perception, eventually leading to an increase in food intake, but the underlying mechanisms remain poorly understood. We found that cannabinoid type-1 (CB1) receptors promote food intake in fasted mice by increasing odor detection. CB1 receptors were abundantly expressed on axon terminals of centrifugal cortical glutamatergic neurons that project to inhibitory granule cells of the main olfactory bulb (MOB). Local pharmacological and genetic manipulations revealed that endocannabinoids and exogenous cannabinoids increased odor detection and food intake in fasted mice by decreasing excitatory drive from olfactory cortex areas to the MOB. Consistently, cannabinoid agonists dampened in vivo optogenetically stimulated excitatory transmission in the same circuit. Our data indicate that cortical feedback projections to the MOB crucially regulate food intake via CB1 receptor signaling, linking the feeling of hunger to stronger odor processing. Thus, CB1 receptor-dependent control of cortical feedback projections in olfactory circuits couples internal states to perception and behavior.
Keywords :
Feeding behaviour
Olfactory bulb
Document type :
Journal articles
Complete list of metadatas
https://hal-pasteur.archives-ouvertes.fr/pasteur-01587186
Contributor : Antoine Nissant <>
Submitted on : Wednesday, September 13, 2017 - 5:47:45 PM
Last modification on : Monday, December 14, 2020 - 3:40:36 PM
Contributor : Antoine Nissant <>
Submitted on : Wednesday, September 13, 2017 - 5:47:45 PM
Last modification on : Monday, December 14, 2020 - 3:40:36 PM
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Identifiers
- HAL Id : pasteur-01587186, version 1
- DOI : 10.1038/nn.3647
- PUBMED : 24509429
- PRODINRA : 256713
- WOS : 000332016500014
Collections
PASTEUR | CNRS | UNIV-PARIS7 | INRA | IMNC | USPC | IN2P3 | INRAE | UNIV-PARIS
Citation
Edgar Soria-Gómez, Luigi Bellocchio, Leire Reguero, Gabriel Lepousez, Claire Martin, et al.. The endocannabinoid system controls food intake via olfactory processes. Nature Neuroscience, Nature Publishing Group, 2014, 17 (3), pp.407 - 415. ⟨10.1038/nn.3647⟩. ⟨pasteur-01587186⟩
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