Skip to Main content Skip to Navigation
Journal articles

The endocannabinoid system controls food intake via olfactory processes

Abstract : Hunger arouses sensory perception, eventually leading to an increase in food intake, but the underlying mechanisms remain poorly understood. We found that cannabinoid type-1 (CB1) receptors promote food intake in fasted mice by increasing odor detection. CB1 receptors were abundantly expressed on axon terminals of centrifugal cortical glutamatergic neurons that project to inhibitory granule cells of the main olfactory bulb (MOB). Local pharmacological and genetic manipulations revealed that endocannabinoids and exogenous cannabinoids increased odor detection and food intake in fasted mice by decreasing excitatory drive from olfactory cortex areas to the MOB. Consistently, cannabinoid agonists dampened in vivo optogenetically stimulated excitatory transmission in the same circuit. Our data indicate that cortical feedback projections to the MOB crucially regulate food intake via CB1 receptor signaling, linking the feeling of hunger to stronger odor processing. Thus, CB1 receptor-dependent control of cortical feedback projections in olfactory circuits couples internal states to perception and behavior.
Document type :
Journal articles
Complete list of metadatas

https://hal-pasteur.archives-ouvertes.fr/pasteur-01587186
Contributor : Antoine Nissant <>
Submitted on : Wednesday, September 13, 2017 - 5:47:45 PM
Last modification on : Monday, September 21, 2020 - 4:24:03 PM

Links full text

Identifiers

Collections

Citation

Edgar Soria-Gómez, Luigi Bellocchio, Leire Reguero, Gabriel Lepousez, Claire Martin, et al.. The endocannabinoid system controls food intake via olfactory processes. Nature Neuroscience, Nature Publishing Group, 2014, 17 (3), pp.407 - 415. ⟨10.1038/nn.3647⟩. ⟨pasteur-01587186⟩

Share

Metrics

Record views

750