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Asynchronous lineage priming determines commitment to T cell and B cell lineages in fetal liver

Abstract : The molecular events that initiate lymphoid-lineage specification remain unidentified because the stages of differentiation during which lineage commitment occurs are difficult to characterize. We isolated fetal liver progenitor cells undergoing restriction of their differentiation potential toward the T cell-innate lymphoid cell lineage or the B cell lineage. Transcripts that defined the molecular signatures of these two subsets were sequentially upregulated in lympho-myeloid precursor cells and in common lymphoid progenitor cells, respectively, and this preceded lineage restriction; this indicates that T cell-versus-B cell commitment is not a binary fate 'decision'. The T cell-bias and B cell-bias transcriptional programs were frequently co-expressed in common lymphoid progenitor cells and were segregated in subsets biased toward T cell differentiation or B cell differentiation, after interleukin 7 (IL-7) signaling that controlled the number of progenitor cells engaging in T cell differentiation versus B cell differentiation.
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Contributor : Marie-Christine Vougny Connect in order to contact the contributor
Submitted on : Friday, September 8, 2017 - 11:13:24 AM
Last modification on : Tuesday, November 16, 2021 - 4:50:48 AM



Claire Berthault, Cyrille Ramond, Odile Burlen-Defranoux, Guillaume Soubigou, Sylvestre Chea, et al.. Asynchronous lineage priming determines commitment to T cell and B cell lineages in fetal liver. Nature Immunology, Nature Publishing Group, 2017, ⟨10.1038/ni.3820⟩. ⟨pasteur-01584003⟩



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