Regulation and phylogeny of skeletal muscle regeneration.

Meryem B Baghdadi (1, 2) , Shahragim Tajbakhsh (2)

1 UPMC - Université Pierre et Marie Curie - Paris 6
2 Cellules Souches et Développement / Stem Cells and Development

One of the most fascinating questions in regenerative biology is why some animals can regenerate injured structures while others cannot. Skeletal muscle has a remarkable capacity to regenerate even after repeated traumas, yet limited information is available on muscle repair mechanisms and how they have evolved. For decades, the main focus in the study of muscle regeneration was on muscle stem cells, however, their interaction with their progeny and stromal cells is only starting to emerge, and this is crucial for successful repair and re-establishment of homeostasis after injury. In addition, numerous murine injury models are used to investigate the regeneration process, and some can lead to discrepancies in observed phenotypes. This review addresses these issues and provides an overview of the some of the main regulatory cellular and molecular players involved in skeletal muscle repair.

Mots clés: evolution; injury; quiescence; regeneration; skeletal muscle; stem cells

Domaines: Organisation et fonctions cellulaires [q-bio.SC]

Meryem B Baghdadi, Shahragim Tajbakhsh. Regulation and phylogeny of skeletal muscle regeneration.. Developmental Biology, 2017, ⟨10.1016/j.ydbio.2017.07.026⟩. ⟨pasteur-01580595⟩