Sphingolipids from the human fungal pathogen Aspergillus fumigatus.

Abstract : Sphingolipids (SPLs) are key components of the plasma membrane in yeast and filamentous fungi. These molecules are involved in a number of cellular processes, and particularly, SGLs are essential components of the highly polarized fungal growth where they are required for the formation of the polarisome organization at the hyphal apex. Aspergillus fumigatus, a human fungal pathogen, produce SGLs that are discriminated into neutral cerebrosides, glycosylinositolphosphoceramides (GIPCs) and glycosylphosphatidylinositol (GPI) anchors. In addition to complex hydrophilic head groups of GIPCs, A. fumigatus is, to date, the sole fungus that produces a GPI-anchored polysaccharide. These SPLs follow three different biosynthetic pathways. Genetics blockage leading to the inhibition of any SPL biosynthesis or to the alteration of the structure of SPL induces growth and virulence defects. The complete lipid moiety of SPLs is essential for the lipid microdomain organization and their biosynthetic pathways are potential antifungal targets but remains understudied.
Type de document :
Article dans une revue
Biochimie, Elsevier, 2017, 〈10.1016/j.biochi.2017.06.012〉
Liste complète des métadonnées

Littérature citée [55 références]  Voir  Masquer  Télécharger

https://hal-pasteur.archives-ouvertes.fr/pasteur-01580433
Contributeur : Anne Lassailly-Bondaz <>
Soumis le : vendredi 1 septembre 2017 - 15:16:11
Dernière modification le : vendredi 1 septembre 2017 - 15:16:34

Fichier

1-s2.0-S0300908417301591-main....
Fichiers produits par l'(les) auteur(s)

Licence


Distributed under a Creative Commons Paternité - Pas d'utilisation commerciale - Partage selon les Conditions Initiales 4.0 International License

Identifiants

Collections

Citation

Thierry Fontaine. Sphingolipids from the human fungal pathogen Aspergillus fumigatus.. Biochimie, Elsevier, 2017, 〈10.1016/j.biochi.2017.06.012〉. 〈pasteur-01580433〉

Partager

Métriques

Consultations de la notice

175

Téléchargements de fichiers

49